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The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians. Cardiovascular Diabetology, 21(1), Article 202. https://doi.org/10.1186/s12933-022-01639-w

Objective: Severe hypoglycemia is associated with increased cardiovascular death risk, and platelet responses to hypoglycemia (hypo) have been described. However, the impact of deep transient hypo (deep-hypo) versus prolonged milder hypo (mild-hypo)... Read More about The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians.

Dosing and Efficacy of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcer Healing: A Systematic Review Protocol (2022)
Journal Article
Hitchman, L. (in press). Dosing and Efficacy of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcer Healing: A Systematic Review Protocol. Journal of Vascular Societies Great Britain and Ireland,

Abstract
Background
Effective interventions to improve diabetic foot ulcer (DFU) healing are urgently required. Extracorporeal shockwave therapy (ESWT) has the potential to transform DFU care but is limited by uncertainties around clinical effectiv... Read More about Dosing and Efficacy of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcer Healing: A Systematic Review Protocol.

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome (2022)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2022). Components of the Complement Cascade Differ in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 23(20), Article 12232. https://doi.org/10.3390/ijms232012232

Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitor... Read More about Components of the Complement Cascade Differ in Polycystic Ovary Syndrome.

Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery (2022)
Journal Article
Ganjooei, N. A., Jamialahmadi, T., Nematy, M., Shah, N. Z., Jangjoo, S., Emami, N., Jangjoo, A., Faridnia, R., Alidadi, M., Sathyapalan, T., & Sahebkar, A. (2022). Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery. Middle East Journal of Digestive Diseases, 14(4), 410-421. https://doi.org/10.34172/mejdd.2022.302

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic fibrosis have emerged as one of the leading causes of chronic liver disease. The prevalence of the NAFLD spectrum has increased, which can be att... Read More about Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery.

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening (2022)
Journal Article
Jahanfar, F., Sadofsky, L., Morice, A., & D’Amico, M. (2022). Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening. Membranes, 12(10), Article 954. https://doi.org/10.3390/membranes12100954

Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca2+-permeable ion channel with multimodal gating which can be activated by low temperatures and cooling compounds, such as menthol and ici... Read More about Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus (2022)
Journal Article
Sadeghi, M., Dehnavi, S., Shohan, M., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2023). Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus. Current medicinal chemistry, 30(14), 1623-1637. https://doi.org/10.2174/0929867329666220817142848

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to e... Read More about Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus.

Protective effects of curcumin on ischemia/reperfusion injury (2022)
Journal Article
Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022). Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research, https://doi.org/10.1002/ptr.7620

Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ d... Read More about Protective effects of curcumin on ischemia/reperfusion injury.

The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis (2022)
Journal Article
Mahdi Seyedzadeh Sani, S., Sahranavard, M., Jannati Yazdanabad, M., Seddigh Shamsi, M., Elyasi, S., Hooshang Mohammadpour, A., Sathyapalan, T., Arasteh, O., Ghavami, V., & Sahebkar, A. (2022). The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis. International immunopharmacology, 112, Article 109227. https://doi.org/10.1016/j.intimp.2022.109227

Background: Changes in the incidence of bleomycin pulmonary toxicity (BPT) as a result of adding colony-stimulating factors (CSF) to bleomycin regimens has been investigated in numerous studies. We performed a systematic review and meta-analysis to a... Read More about The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis.

Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms (2022)
Journal Article
Sykes, D. L., Crooks, M. G., Hart, S. P., Jackson, W., Gallagher, J., & Morice, A. H. (2022). Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms. Respiratory medicine, 202, Article 106985. https://doi.org/10.1016/j.rmed.2022.106985

Background: The interaction between the respiratory and gastrointestinal systems, and the role of the latter in the development of respiratory pathology, has been examined with a focus on gastro-oesophageal reflux disease (GORD). However, little data... Read More about Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms.

Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review (2022)
Journal Article
Javid, H., Karimi-Shahri, M., Khorramdel, M., Mashhad, A. S., Tabrizi, A. T., Sathyapalan, T., Afshari, A.-R., & Sahebkar, A. (2023). Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review. Current medicinal chemistry, 30(4), 390-406. https://doi.org/10.2174/0929867329666220511185745

The immune system's role in maintaining the health of the gastrointestinal (GI) system is like a double-edged sword. Simultaneously, it could reduce the risk of pathogen invasion by the inflammatory response. However, if regulated improperly, it coul... Read More about Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review.

Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites. Nutrients, 14(17), Article 3540. https://doi.org/10.3390/nu14173540

INTRODUCTION: Chronic low-grade inflammation is a characteristic of women with polycystic ovary syndrome (PCOS), although this may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, vitamin D deficiency, another common feature of... Read More about Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites.

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., Kilvert, A., Lumb, A., Christian, P., Barnes, D., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., Harris, K., Kruusmägi, M., Walther, T., Booth, J., Boa, A. N., Archibald, S. J., Thompson, C., Atkin, S. L., & Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings (2022)
Journal Article
Hutchinson, A., Allgar, V., Cohen, J., Currow, D. C., Griffin, S., Hart, S., Hird, K., Hodge, A., Mason, S., Northgraves, M., Reeve, J., Swan, F., & Johnson, M. J. (2022). Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings. ERJ Open Research, 8(4), Article 00257-2022. https://doi.org/10.1183/23120541.00257-2022

Introduction: One-fifth of emergency department presentations by ambulance are due to acute-on-chronic breathlessness. We explored the feasibility of an evaluation-phase, cluster randomised controlled trial (cRCT) of the effectiveness and cost-effect... Read More about Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings.

Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit (2022)
Journal Article
Pieri, B., Deshmukh, H., Wilmot, E. G., Choudhary, P., Shah, N., Gregory, R., Barnes, D., Saunders, S., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2023). Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit. Diabetes, Obesity and Metabolism, 25(1), 302-305. https://doi.org/10.1111/dom.14841

Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study (2022)
Journal Article
Curry, J., Lind, M., Short, C. E., Vandelanotte, C., Evans, H. E., Pearson, M., & Forbes, C. C. (2022). Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study. Pilot and Feasibility Studies, 8(1), Article 182. https://doi.org/10.1186/s40814-022-01129-6

Background: Lung cancer is the leading cause of cancer-related death globally. Physical activity and exercise provide unequivocal benefits to those living with and beyond lung cancer. However, few of those living with and beyond cancer meet the natio... Read More about Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study.

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes (2022)
Journal Article
Ramanjaneya, M., Priyanka, R., Bensila, M., Jerobin, J., Pawar, K., Sathyapalan, T., Abou-Samra, A. B., Halabi, N. M., Moin, A. S. M., Atkin, S. L., & Butler, A. E. (2022). MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes. Frontiers in endocrinology, 13, Article 917041. https://doi.org/10.3389/fendo.2022.917041

Objective: Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding micr... Read More about MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes.

Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis (2022)
Journal Article
Lathan, R., Sidapra, M., Yiasemidou, M., Long, J., Totty, J., Smith, G., & Chetter, I. (2022). Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis. npj Digital Medicine, 5(1), Article 108. https://doi.org/10.1038/s41746-022-00655-0

The Sars-CoV-2 pandemic catalysed integration of telemedicine worldwide. This systematic review assesses it’s accuracy for diagnosis of Surgical Site Infection (SSI). Databases were searched for telemedicine and wound infection studies. All types of... Read More about Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis.