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Postradioiodine Graves' management: The PRAGMA study (2022)
Journal Article
Perros, P., Basu, A., Boelaert, K., Dayan, C., Vaidya, B., Williams, G. R., Lazarus, J. H., Hickey, J., Drake, W. M., Crown, A., Orme, S. M., Johnson, A., Ray, D. W., Leese, G. P., Hugh Jones, T., Abraham, P., Grossman, A., Rees, A., Razvi, S., Gibb, F. W., …Karavitaki, N. (2022). Postradioiodine Graves' management: The PRAGMA study. Clinical Endocrinology, https://doi.org/10.1111/cen.14719

Objective: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of common management strategies.... Read More about Postradioiodine Graves' management: The PRAGMA study.

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis (2022)
Preprint / Working Paper
Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Increasing age is the main risk factor for chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF). Halting or reversing progression of IPF remains an unmet clinical need due to limited knowledge of underlying mechanisms. In particu... Read More about Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis.

Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology (2022)
Journal Article
Sahebkar, A., Sathyapalan, T., Guest, P. C., & Barreto, G. E. (2022). Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology. Biomedicine and Pharmacotherapy, 148, Article 112770. https://doi.org/10.1016/j.biopha.2022.112770

Traumatic brain injury (TBI) affects approximately 50% of the world population at some point in their lifetime. To date, there are no effective treatments as most of the damage occurs due to secondary effects through a variety of pathophysiological p... Read More about Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology.

Treatment of chronic cough: P2X3 receptor antagonists and beyond (2022)
Journal Article
Sykes, D. L., Zhang, M., & Morice, A. H. (2022). Treatment of chronic cough: P2X3 receptor antagonists and beyond. Pharmacology and Therapeutics, 237, Article 108166. https://doi.org/10.1016/j.pharmthera.2022.108166

For years chronic cough (CC) has presented an enormous physical, psychological, and social burden on those who experience it, with no approved pharmacological therapies to assuage their symptoms. With our improved understanding of the pathophysiologi... Read More about Treatment of chronic cough: P2X3 receptor antagonists and beyond.

A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging (2022)
Journal Article
Mesgari, M., Aalami, A. H., Sathyapalan, T., & Sahebkar, A. (2022). A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging. Bioinorganic Chemistry and Applications, 2022, Article 7557825. https://doi.org/10.1155/2022/7557825

Background. Food nanopackaging helps maintain food quality against physical, chemical, and storage instability factors. Copper oxide nanoparticles (CuONPs) can improve biopolymers' mechanical features and barrier properties. This will lead to antimic... Read More about A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging.

Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature (2022)
Journal Article
Hatamipour, M., Hadizadeh, F., Jaafari, M. R., Khashyarmanesh, Z., Sathyapalan, T., & Sahebkar, A. (2022). Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature. Current medicinal chemistry, 29(8), 1459-1471. https://doi.org/10.2174/0929867328666210910141316

BACKGROUND: Curcuminoids, flavoring, and coloring agents in food have potent antioxidant, anti-tumor activity, and anti-inflammatory effects. However, they are rapidly metabolized to lesser active metabolites. Therefore, various studies have been con... Read More about Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature.

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials (2022)
Journal Article
McGarvey, L. P., Birring, S. S., Morice, A. H., Dicpinigaitis, P. V., Pavord, I. D., Schelfhout, J., Nguyen, A. M., Li, Q., Tzontcheva, A., Iskold, B., Green, S. A., Rosa, C. L., Muccino, D. R., & Smith, J. A. (2022). Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet, 399(10328), 909-923. https://doi.org/10.1016/S0140-6736%2821%2902348-5

Background: Gefapixant is an oral P2X3 receptor antagonist that has previously shown efficacy and safety in refractory chronic cough and unexplained chronic cough. We therefore aim to confirm the efficacy and safety of gefapixant in participants with... Read More about Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.

The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery (2022)
Journal Article
Jamialahmadi, T., Nematy, M., Abdalla, M., Jangjoo, A., Goshayeshi, L., Kroh, M., Moallem, S. A., Abbasifard, M., Sathyapalan, T., & Sahebkar, A. (2022). The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery. Journal of Nutrition and Metabolism, 2022, Article 7319742. https://doi.org/10.1155/2022/7319742

Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity... Read More about The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.

Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization. Metabolites, 12(3), Article 196. https://doi.org/10.3390/metabo12030196

Development of type-2 diabetes(T2D) is preceded by β-cell dysfunction and loss. How-ever, accurate measurement of β-cell function remains elusive. Biomarkers have been reported to predict β-cell functional decline but require validation. Therefore, w... Read More about Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women (2022)
Journal Article
Ramanjaneya, M., Abdalhakam, I., Bettahi, I., Bensila, M., Jerobin, J., Aye, M. M., Alkasem, M., Sathyapalan, T., Atkin, S. L., & Abou-Samra, A. B. (2022). Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women. Frontiers in endocrinology, 12, Article 740703. https://doi.org/10.3389/fendo.2021.740703

Background: The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, al... Read More about Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis (2022)
Journal Article
Akbari, A., Rafiee, M., Sathyapalan, T., & Sahebkar, A. (2022). Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis. Journal of Diabetes Research, 2022, Article 7520632. https://doi.org/10.1155/2022/7520632

Background: Several trials have assessed the antihyperglycemic effects of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM). We conducted a quantitative analysis to assess the impact of SGLT2is on ser... Read More about Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.

The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication (2022)
Journal Article
Ibeggazene, S., Cai, P. L., Smith, G. E., Ibbegazene, S., Stirrup, A., Pymer, S., Palmer, J., Cai, P., Smith, G., & Chetter, I. C. (in press). The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication. Vascular, https://doi.org/10.1177/17085381211059665

Background: The screening and diagnosis of intermittent claudication is a challenging process and often relies on the expertise of specialist vascular clinicians. We sought to investigate the diagnostic performance of the Edinburgh Claudication Quest... Read More about The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication.

The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19 (2022)
Journal Article
Saghafi, N., Rezaee, S. A., Momtazi-Borojeni, A. A., Tavasolian, F., Sathyapalan, T., Abdollahi, E., & Sahebkar, A. (2022). The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19. Life Sciences, 294, Article 120392. https://doi.org/10.1016/j.lfs.2022.120392

The SARS coronavirus 2 (SARS CoV-2) causes Coronavirus Disease (COVID-19), is an emerging viral infection. SARS CoV-2 infects target cells by attaching to Angiotensin-Converting Enzyme (ACE2). SARS CoV-2 could cause cardiac damage in patients with se... Read More about The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease (2022)
Journal Article
Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2022). PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology, 20(2), 309-323. https://doi.org/10.2174/1570159X19666210823103020

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic ne... Read More about PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease.

A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication (2022)
Journal Article
Ibeggazene, S., Pymer, S., Birkett, S. T., Caldow, E., & Harwood, A. E. (in press). A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication. Vascular, https://doi.org/10.1177/17085381211070700

Background: Exercise therapy is an important treatment option for people with intermittent claudication (IC). Appropriate reporting of exercise interventions in populations with IC within randomised controlled trials (RCTs) is important to ensure tha... Read More about A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication.

Tenotomy for diabetic foot ulcers: a scoping survey of current practice (2022)
Journal Article
Hitchman, L., Nandhra, S., Gooday, C., Cowan, C., Bowling, F., Nixon, J., Pickard, J., Cohen, J., Atkin, L., Rudarakanchana, N., Collings, R., Kavarthapu, V., Shalhoub, J., Games, F., & Russell, D. (2022). Tenotomy for diabetic foot ulcers: a scoping survey of current practice. Journal of Vascular Societies Great Britain and Ireland, 1(2), 54-58. https://doi.org/10.54522/jvsgbi.2022.006

Background: Diabetes mellitus is one of the fastest growing health crises of our time. One of the major complications is diabetic foot ulcers, many of which fail to heal. Tenotomy – transection of tendon fibres – may help to redistribute pressure in... Read More about Tenotomy for diabetic foot ulcers: a scoping survey of current practice.

Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership (2022)
Journal Article
Pymer, S., Harwood, A., Long, J., Chetter, I., Saratzis, A., & Coughlin, P. (2022). Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership. Journal of Vascular Societies Great Britain and Ireland, 1(2), 23-29. https://doi.org/10.54522/jvsgbi.2022.011

Introduction: Peripheral arterial disease (PAD) is a common health problem associated with reduced mobility, functional capacity and quality of life. Significant research exists in the field of vascular surgery, but its relevance to the research prio... Read More about Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership.

Defining priorities in vascular access research (2022)
Journal Article
De Siqueira, J., Fielding, C., Pettigrew, G., Robson, M., Rogers, S., Steiner, K., Withers, W., Long, J., Gronlund, T., Chetter, I., & Smith, G. (2022). Defining priorities in vascular access research. Journal of Vascular Societies Great Britain and Ireland, 1(2), 30-33. https://doi.org/10.54522/jvsgbi.2022.013

Introduction: There is increasing need for renal replacement therapy associated with the aging population and dramatic increases in diabetes prevalence. Despite an increasing clinical vascular access workload, there are significant unanswered researc... Read More about Defining priorities in vascular access research.