All Outputs (8)

The role of WSB-1 as a BRCAness biomarker in breast cancer (2023)
Thesis
Li, . C. The role of WSB-1 as a BRCAness biomarker in breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4436228

Background
Radiotherapy currently has become one of the major therapeutic approaches in the treatments for cancers. However, hypoxia presents a significant challenge to the effectiveness of radiotherapy and is associated with radio-resistance. Previ... Read More about The role of WSB-1 as a BRCAness biomarker in breast cancer.

Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I (2023)
Thesis
Bolanle, O. I. Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4420724

Despite the plethora of drugs currently available for managing coronary artery disease (CAD) patients with or without type 2 diabetes mellitus (T2DM), yet CAD frequently progresses, necessitating a coronary artery bypass graft (CABG) procedure using... Read More about Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I.

T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer (2023)
Thesis
Tantoush, F. A. A. T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4373985

Bacterial superantigens (SAgs) trigger oligoclonal activation of T cells by crosslinking MHC-class-II, on Ag-presenting cells, to the T cell receptor (TCR)/CD28, on T cells, which can be independent of Lck, a critical kinase normally involved... Read More about T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer.

Investigating protein arginine methylation in platelets and hair (2023)
Thesis
Marsden, A. J. Investigating protein arginine methylation in platelets and hair. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4386508

Post-translational modification (PTM) of platelet proteins has long been known to have an effect on their ability to aggregate and form a thrombus. Arginine methylation (ArgMe) is catalysed by protein arginine methyltransferases (PRMTs) which... Read More about Investigating protein arginine methylation in platelets and hair.

Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system (2023)
Thesis
Saldanha, P. A. C. B. D. S. Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4790706

Regulation of actomyosin-driven contraction is important for numerous cardiovascular cell functions, including smooth muscle tone, endothelial cell permeability and platelet shape change and spreading. These processes are primarily regulated by the p... Read More about Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system.

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.