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Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. (2017). Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagulation and Fibrinolysis, 28(8), 602-611. https://doi.org/10.1097/mbc.0000000000000644

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Calibrated automated thrombography (CAT) is emerging as a reliable tool for real-Time estimation of thrombin generation potential. There is a clinical need for knowledge about the pathways under... Read More about Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography.

Minkowski functionals: An MRI texture analysis tool for determination of the aggressiveness of breast cancer (2015)
Journal Article
Fox, M. J., Gibbs, P., & Pickles, M. D. (2016). Minkowski functionals: An MRI texture analysis tool for determination of the aggressiveness of breast cancer. Journal of magnetic resonance imaging : JMRI, 43(4), 903-910. https://doi.org/10.1002/jmri.25057

Purpose: This work aims to see whether Minkowski Functionals can be used to distinguish between cancer types before chemotherapy treatment has begun, and whether a response to treatment can be predicted by an initial scan alone. Methods: Fat-nulled T... Read More about Minkowski functionals: An MRI texture analysis tool for determination of the aggressiveness of breast cancer.

Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer (2011)
Journal Article
Ettelaie, C., Gardiner, E., Maraveyas, A., Bozas, G., Fyfe, D., Lofts, F., …Wedgwood, K. (2012). Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. European Journal of Cancer, 48(9), (1283-1292). doi:10.1016/j.ejca.2011.10.017. ISSN 1879-0852

Background: Annualised figures show an up to 7-fold higher incidence of vascular thromboembolism (VTE) in patients with advanced pancreatic cancer (APC) compared to other common malignancies. Concurrent VTE has been shown to confer a worse overall pr... Read More about Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer.

Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol (2011)
Journal Article
Sharma, A., Liu, B., Waudby, P., & Duthie, G. S. (2011). Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol. International Journal of Colorectal Disease, 26(12), (1583-1587). doi:10.1007/s00384-011-1257-x. ISSN 0179-1958

Background Constipation is a common multifactorial gastrointestinal symptom with quality of life implications. Sacral neuromodulation has been used in the management of severe constipation with mixed results. The aim of this study was to review our... Read More about Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol.

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer (2010)
Journal Article
Valle, J., Wasan, H., Palmer, D. H., Cunningham, D., Anthoney, A., Maraveyas, A., …Bridgewater, J. (2010). Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New England Journal of Medicine, 362(14), (1273-1281). doi:10.1056/NEJMoa0908721. ISSN 1533-4406

BACKGROUND:There is no established standard chemotherapy for patients with locally advanced or metastatic biliary tract cancer. We initially conducted a randomized, phase 2 study involving 86 patients to compare cisplatin plus gemcitabine with gemcit... Read More about Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.

Quality assurance in colonoscopy: role of endomucosal clips (2009)
Journal Article
Maslekar, S., Avery, G., & Duthie, G. S. (2010). Quality assurance in colonoscopy: role of endomucosal clips. Colorectal Disease, 12(7), 651-656. doi:10.1111/j.1463-1318.2009.01874.x

Objective Quality assurance in colonoscopy is important, and subjective assessment of completion based on endoscopic signs can be inaccurate leading to missed lesions. We aimed to determine the technique of endomucosal clips with follow-up X-rays in... Read More about Quality assurance in colonoscopy: role of endomucosal clips.

Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy (2009)
Journal Article
Maslekar, S., Gardiner, A., Hughes, M., Culbert, B., & Duthie, G. S. (2009). Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy. British journal of surgery : BJS, 96(4), 361-368. doi:10.1002/bjs.6467

Background: Intravenous sedation for colonoscopy is associated with cardiorespiratory complications and delayed recovery. The aim of this randomized clinical trial was to compare the efficacy of Entonox ® (50 per cent nitrous oxide and 50 per cent o... Read More about Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy.

Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy (2007)
Journal Article
Tan, P. C., Pickles, M. D., Lowry, M., Manton, D. J., & Turnbull, L. W. (2008). Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy. Magnetic Resonance Imaging, 26(1), (26-34). doi:10.1016/j.mri.2007.04.002. ISSN 0730-725X

The aim of this study was to investigate the utility of the water T-2 values of malignant breast lesions in predicting response after the first and second cycles of neoadjuvant chemotherapy (NAC), both alone and in combination with lesion volumes. Th... Read More about Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy.

Randomised controlled trial of sedation for colonoscopy: Entonox versus intravenous sedation (2006)
Journal Article
Maslekar, S. K., Hughes, M., Skinn, E., Gardiner, A., Culbert, B., & Duthie, G. S. (2006). Randomised controlled trial of sedation for colonoscopy: Entonox versus intravenous sedation. Gastrointestinal Endoscopy, 63(5), AB97. doi:10.1016/j.gie.2006.03.087

Introduction: Intravenous sedation for colonoscopy is associated with cardio-respiratory complications, delayed recovery and prolonged drowsiness. We aimed to determine whether inhaled Entonox

Non-medical colonoscopy (2006)
Journal Article
Maslekar, S. K., Gardiner, A., Hughes, M., & Duthie, G. S. (2006). Non-medical colonoscopy. Gastrointestinal Endoscopy, 63(5), AB114. doi:10.1016/j.gie.2006.03.148

Aims: There is increasing demand for colonoscopy especially with introduction of screening programmes. Though colonoscopy is performed by doctors and nurses, there is an acute shortage of trained colonoscopists

Abstracts of the AGA Institute (2006)
Journal Article
Gardiner, A., Maslekar, S., & Duthie, G. (2006). Abstracts of the AGA Institute. Gastroenterology, 130(4), A-1-A-747. doi:10.1016/s0016-5085(06)60008-5

Aims: Artificial neural networks (ANN) are computer programs used to identify complexrelations within data that cannot be detected with conventional linear-statistical analysis.The routine clinical predictions of need for lower gastrointestinal endos... Read More about Abstracts of the AGA Institute.

Rectal irrigation for relief of functional bowel disorders (2004)
Journal Article
Gardiner, A., Marshall, J., & Duthie, G. (2004). Rectal irrigation for relief of functional bowel disorders. Nursing standard : official newspaper of the Royal College of Nursing, 19(9), 39-42. doi:10.7748/ns2004.11.19.9.39.c3755

This article examines the use of rectal irrigation for the symptomatic relief of functional bowel disorders in certain groups of patients. The authors undertook a study of 80 patients and conclude that it is a valuable treatment for some patients.

Neural network analysis of anal sphincter repair (2004)
Journal Article
Gardiner, A., Kaur, G., Cundall, J., Ilstrup, D. M., Gardiner, A., & Duthie, G. (2004). Neural network analysis of anal sphincter repair. Diseases of the colon & rectum, 47(2), 192-197. doi:10.1007/s10350-003-0026-5

PURPOSE: Prediction of success after anterior sphincter repair for incontinence is difficult. Standard multivariate analysis techniques have only 75 to 80 percent accuracy. Artificial intelligence, including artificial neural networks, has been used... Read More about Neural network analysis of anal sphincter repair.

Do rectal suppositories have any effect on sphincter work? (2000)
Journal Article
Kaur, G., Gardiner, A., Lee, P. W., Monson, J. R., & Duthie, G. S. (2000). Do rectal suppositories have any effect on sphincter work?. Gastroenterology, 118(4), A1180 - A1180. doi:10.1016/S0016-5085(00)80547-8