University of Hull logo

Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. (2017). Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagulation and Fibrinolysis, 28(8), 602-611. https://doi.org/10.1097/mbc.0000000000000644

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Calibrated automated thrombography (CAT) is emerging as a reliable tool for real-Time estimation of thrombin generation potential. There is a clinical need for knowledge about the pathways under... Read More

Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy (2016)
Journal Article
Broughton, L. J., Giuntini, F., Savoie, H., Bryden, F., Boyle, R. W., Maraveyas, A., & Madden, L. A. (2016). Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy. Journal of photochemistry and photobiology. B, Biology, 163, 374-384. https://doi.org/10.1016/j.jphotobiol.2016.09.001

Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through deliv... Read More

Minkowski functionals: An MRI texture analysis tool for determination of the aggressiveness of breast cancer (2015)
Journal Article
Fox, M. J., Gibbs, P., & Pickles, M. D. (2016). Minkowski functionals: An MRI texture analysis tool for determination of the aggressiveness of breast cancer. Journal of magnetic resonance imaging : JMRI, 43(4), 903-910. https://doi.org/10.1002/jmri.25057

Purpose: This work aims to see whether Minkowski Functionals can be used to distinguish between cancer types before chemotherapy treatment has begun, and whether a response to treatment can be predicted by an initial scan alone. Methods: Fat-nulled T... Read More

Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer (2011)
Journal Article
Ettelaie, C., Gardiner, E., Maraveyas, A., Bozas, G., Fyfe, D., Lofts, F., …Wedgwood, K. (2012). Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. European Journal of Cancer, 48(9), (1283-1292). doi:10.1016/j.ejca.2011.10.017. ISSN 1879-0852

Background: Annualised figures show an up to 7-fold higher incidence of vascular thromboembolism (VTE) in patients with advanced pancreatic cancer (APC) compared to other common malignancies. Concurrent VTE has been shown to confer a worse overall pr... Read More

Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol (2011)
Journal Article
Sharma, A., Liu, B., Waudby, P., & Duthie, G. S. (2011). Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol. International Journal of Colorectal Disease, 26(12), (1583-1587). doi:10.1007/s00384-011-1257-x. ISSN 0179-1958

Background Constipation is a common multifactorial gastrointestinal symptom with quality of life implications. Sacral neuromodulation has been used in the management of severe constipation with mixed results. The aim of this study was to review our... Read More

Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis (2011)
Journal Article
Hodgkinson, V. C., ELFadl, D., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis. Journal of Proteomics, 74(5), (698-703). doi:10.1016/j.jprot.2011.02.014. ISSN 1874-3919

Antibody microarrays are powerful new tools in the field of comparative proteomics. The success of the biomarker discovery pipeline relies on the quality of data generated in the discovery phase and careful selection of proteins for the verification... Read More

Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? (2010)
Journal Article
Agarwal, V., Lind, M. J., & Cawkwell, L. (2011). Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?. Cancer Treatment Reviews, 37(7), (533-542). doi:10.1016/j.ctrv.2010.11.004. ISSN 1532-1967

The median survival for patients with malignant pleural mesothelioma remains extremely poor and there is a need for the development of more effective treatment modalities. The epidermal growth factor receptor is frequently over-expressed in malignant... Read More

Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy (2010)
Journal Article
Murray, A., Little, S. J., Stanley, P., Cawkwell, L., & Maraveyas, A. (2010). Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy. Oncology Reports, 24(4), 1049-1058. doi:10.3892/or-00000954

Angiogenesis inhibitors may enhance the effects of low dose (metronomic) chemotherapy. However, there is a wide range of novel angiogenesis inhibitors which must be tested in combinations with oral chemotherapy agents to assess the anti-endothelial a... Read More

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer (2010)
Journal Article
Valle, J., Wasan, H., Palmer, D. H., Cunningham, D., Anthoney, A., Maraveyas, A., …Bridgewater, J. (2010). Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New England Journal of Medicine, 362(14), (1273-1281). doi:10.1056/NEJMoa0908721. ISSN 1533-4406

BACKGROUND:There is no established standard chemotherapy for patients with locally advanced or metastatic biliary tract cancer. We initially conducted a randomized, phase 2 study involving 86 patients to compare cisplatin plus gemcitabine with gemcit... Read More

Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status (2010)
Journal Article
Hodgkinson, V. C., Eagle, G. L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2010). Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status. Cancer Letters, 294(1), (13-24). doi:10.1016/j.canlet.2010.01.036. ISSN 0304-3835

This review describes and discusses the advantages and limitations of proteomic approaches in the identification of biomarkers associated with chemotherapy resistance. Both gel-based (two-dimensional polyacrylamide gel electrophoresis) and gel-free (... Read More

Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? (2009)
Journal Article
Smith, L., Qutob, O., Watson, M. B., Beavis, A. W., Potts, D., Welham, K. J., …Cawkwell, L. (2009). Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?. Neoplasia, 11(11), (1194-1207). doi:10.1593/neo.09902. ISSN 1522-8002

PURPOSE: We aimed to identify putative predictive protein biomarkers of radioresistance. EXPERIMENTAL DESIGN: Three breast cancer cell lines (MCF7, MDA-MB-231, and T47D) were used as in vitro models to study radioresistance. Inherent radiosensitiviti... Read More

COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines (2009)
Journal Article
O'Kane, S. L., Eagle, G. L., Greenman, J., Lind, M. J., & Cawkwell, L. (2010). COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. Lung Cancer, 67(2), (160-165). doi:10.1016/j.lungcan.2009.04.008. ISSN 0169-5002

BACKGROUND Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average survival of 10 months from diagnosis. The choice of chemotherapy regimens for mesothelioma patients is l... Read More

Quality assurance in colonoscopy: role of endomucosal clips (2009)
Journal Article
Maslekar, S., Avery, G., & Duthie, G. S. (2010). Quality assurance in colonoscopy: role of endomucosal clips. Colorectal Disease, 12(7), 651-656. doi:10.1111/j.1463-1318.2009.01874.x

Objective Quality assurance in colonoscopy is important, and subjective assessment of completion based on endoscopic signs can be inaccurate leading to missed lesions. We aimed to determine the technique of endomucosal clips with follow-up X-rays in... Read More

Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy (2009)
Journal Article
Maslekar, S., Gardiner, A., Hughes, M., Culbert, B., & Duthie, G. S. (2009). Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy. British journal of surgery : BJS, 96(4), 361-368. doi:10.1002/bjs.6467

Background: Intravenous sedation for colonoscopy is associated with cardiorespiratory complications and delayed recovery. The aim of this randomized clinical trial was to compare the efficacy of Entonox ® (50 per cent nitrous oxide and 50 per cent o... Read More

Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy (2007)
Journal Article
Tan, P. C., Pickles, M. D., Lowry, M., Manton, D. J., & Turnbull, L. W. (2008). Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy. Magnetic Resonance Imaging, 26(1), (26-34). doi:10.1016/j.mri.2007.04.002. ISSN 0730-725X

The aim of this study was to investigate the utility of the water T-2 values of malignant breast lesions in predicting response after the first and second cycles of neoadjuvant chemotherapy (NAC), both alone and in combination with lesion volumes. Th... Read More

Abstracts of the AGA Institute (2006)
Journal Article
Gardiner, A., Maslekar, S., & Duthie, G. (2006). Abstracts of the AGA Institute. Gastroenterology, 130(4), A-1-A-747. doi:10.1016/s0016-5085(06)60008-5

Aims: Artificial neural networks (ANN) are computer programs used to identify complexrelations within data that cannot be detected with conventional linear-statistical analysis.The routine clinical predictions of need for lower gastrointestinal endos... Read More

Non-medical colonoscopy (2006)
Journal Article
Maslekar, S. K., Gardiner, A., Hughes, M., & Duthie, G. S. (2006). Non-medical colonoscopy. Gastrointestinal Endoscopy, 63(5), AB114. doi:10.1016/j.gie.2006.03.148

Aims: There is increasing demand for colonoscopy especially with introduction of screening programmes. Though colonoscopy is performed by doctors and nurses, there is an acute shortage of trained colonoscopists

Randomised controlled trial of sedation for colonoscopy: Entonox versus intravenous sedation (2006)
Journal Article
Maslekar, S. K., Hughes, M., Skinn, E., Gardiner, A., Culbert, B., & Duthie, G. S. (2006). Randomised controlled trial of sedation for colonoscopy: Entonox versus intravenous sedation. Gastrointestinal Endoscopy, 63(5), AB97. doi:10.1016/j.gie.2006.03.087

Introduction: Intravenous sedation for colonoscopy is associated with cardio-respiratory complications, delayed recovery and prolonged drowsiness. We aimed to determine whether inhaled Entonox

Rectal irrigation for relief of functional bowel disorders (2004)
Journal Article
Gardiner, A., Marshall, J., & Duthie, G. (2004). Rectal irrigation for relief of functional bowel disorders. Nursing standard : official newspaper of the Royal College of Nursing, 19(9), 39-42. doi:10.7748/ns2004.11.19.9.39.c3755

This article examines the use of rectal irrigation for the symptomatic relief of functional bowel disorders in certain groups of patients. The authors undertook a study of 80 patients and conclude that it is a valuable treatment for some patients.

Neural network analysis of anal sphincter repair (2004)
Journal Article
Gardiner, A., Kaur, G., Cundall, J., Ilstrup, D. M., Gardiner, A., & Duthie, G. (2004). Neural network analysis of anal sphincter repair. Diseases of the colon & rectum, 47(2), 192-197. doi:10.1007/s10350-003-0026-5

PURPOSE: Prediction of success after anterior sphincter repair for incontinence is difficult. Standard multivariate analysis techniques have only 75 to 80 percent accuracy. Artificial intelligence, including artificial neural networks, has been used... Read More