All Outputs (514)

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings (2022)
Journal Article
Hutchinson, A., Allgar, V., Cohen, J., Currow, D. C., Griffin, S., Hart, S., …Johnson, M. J. (2022). Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings. ERJ Open Research, 8(4), Article 00257-2022. https://doi.org/10.1183/23120541.00257-2022

Introduction: One-fifth of emergency department presentations by ambulance are due to acute-on-chronic breathlessness. We explored the feasibility of an evaluation-phase, cluster randomised controlled trial (cRCT) of the effectiveness and cost-effect... Read More about Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): study findings.

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes (2022)
Journal Article
Ramanjaneya, M., Priyanka, R., Bensila, M., Jerobin, J., Pawar, K., Sathyapalan, T., …Butler, A. E. (2022). MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes. Frontiers in endocrinology, 13, Article 917041. https://doi.org/10.3389/fendo.2022.917041

Objective: Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding micr... Read More about MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes.

Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis (2022)
Journal Article
Lathan, R., Sidapra, M., Yiasemidou, M., Long, J., Totty, J., Smith, G., & Chetter, I. (2022). Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis. npj Digital Medicine, 5(1), Article 108. https://doi.org/10.1038/s41746-022-00655-0

The Sars-CoV-2 pandemic catalysed integration of telemedicine worldwide. This systematic review assesses it’s accuracy for diagnosis of Surgical Site Infection (SSI). Databases were searched for telemedicine and wound infection studies. All types of... Read More about Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis.

Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups (2022)
Journal Article
Smith, J. A., Birring, S. S., Dicpinigaitis, P. V., McGarvey, L. P., Morice, A. H., Pavord, I. D., …Muccino, D. (2022). Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups. Lung, 200(4), 423-429. https://doi.org/10.1007/s00408-022-00553-y

Introduction: In phase 3 trials (COUGH-1/COUGH-2), gefapixant 45 mg twice daily significantly reduced 24-h cough frequency vs placebo in refractory or unexplained chronic cough (RCC or UCC). Methods: Here, the efficacy of gefapixant 45 mg vs placebo... Read More about Improvements in Objective and Subjective Measures of Chronic Cough with Gefapixant: A Pooled Phase 3 Efficacy Analysis of Predefined Subgroups.

Research priorities in diabetic foot disease (2022)
Journal Article
Collings, R., Shalhoub, J., Atkin, L., Game, F., Hitchman, L., Long, J., …Russell, D. (2022). Research priorities in diabetic foot disease. Journal of Vascular Societies Great Britain and Ireland, 1(4), 124-129. https://doi.org/10.54522/jvsgbi.2022.031

Introduction: Diabetic foot disease is a life-changing event for patients and is associated with high burdens to society in terms of cost, mortality and morbidity. The Vascular Society Diabetic Foot Specialist Interest Group (VSDFSIG), in association... Read More about Research priorities in diabetic foot disease.

The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature (2022)
Journal Article
Arab, A., Karimi, E., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature. Current medicinal chemistry, 29(33), 5462-5473. https://doi.org/10.2174/0929867329666220415114343

Background: To date, many investigations have employed pro-/synbiotic to examine their effects on chemotherapy-related side effects; nevertheless, their findings are inconclu-sive. To address this issue, we carried out a systematic review to explore... Read More about The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature.

A survey of surgical site infection prevention practice in UK vascular surgery (2022)
Journal Article
lathan, R., yiasemidou, M., long, J., Mohamed, A., hitchman, L., smith, G., & Chetter, I. (2022). A survey of surgical site infection prevention practice in UK vascular surgery. Journal of Vascular Societies Great Britain and Ireland, 1(4), 117-123. https://doi.org/10.54522/jvsgbi.2022.030

Background: Surgical site infections (SSI) have a significant impact on morbidity and mortality within vascular surgery. Despite the publication of several guidelines, there is a lack of consensus regarding the most effective perioperative practice t... Read More about A survey of surgical site infection prevention practice in UK vascular surgery.

Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial (2022)
Journal Article
Birkett, S., Sinclair, J., Seed, S., Pymer, S., Caldow, E., Ingle, L., …Egun, A. (2022). Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial. Therapeutic Advances in Cardiovascular Disease, 16, https://doi.org/10.1177/17539447221108817

Background: Peripheral artery disease affects over 236 million people globally and the classic symptom is intermittent claudication (IC) which is associated with reduction in physical activity. The evidence that supervised exercise programmes (SEPs)... Read More about Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial.

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure (2022)
Journal Article
Kazmi, S., Kambhampati, C., Cleland, J., Cuthbert, J., Kazmi, K. S., Pellicori, P., …Clark, A. L. (2022). Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.14028

Aims: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF). Methods and results: We describe... Read More about Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.

The impact of COVID19 on the presentation, diagnosis and management of cutaneous melanoma and squamous cell carcinoma in a single tertiary referral centre (2022)
Journal Article
McClean, A., Matteucci, P., & Totty, J. (in press). The impact of COVID19 on the presentation, diagnosis and management of cutaneous melanoma and squamous cell carcinoma in a single tertiary referral centre. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, https://doi.org/10.1016/j.bjps.2022.06.062

The SARS-CoV-2 pandemic has had a substantial impact on the provision of surgical services worldwide1. In the United Kingdom, staff redeployment and reduced staffing due to infection and self-isolation has reduced the availability of clinic slots and... Read More about The impact of COVID19 on the presentation, diagnosis and management of cutaneous melanoma and squamous cell carcinoma in a single tertiary referral centre.

Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study (2022)
Journal Article
Friedrich, C., Francke, K., Gashaw, I., Scheerans, C., Klein, S., Fels, L., …Morice, A. (2022). Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study. Clinical Pharmacokinetics, 61, 1143–1156. https://doi.org/10.1007/s40262-022-01126-1

Background and Objective: There is no licensed treatment for refractory chronic cough; off-label therapies have limited efficacy and can produce adverse effects. Excessive adenosine triphosphate signaling via P2X3 receptors is implicated in refractor... Read More about Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study.

Compression following treatment of superficial venous incompetence: systematic review (2022)
Journal Article
Mohamed, A. H., Thadani, S., Mohamed, S. H., Sidapra, M., Smith, G., Chetter, I., & Carradice, D. (2022). Compression following treatment of superficial venous incompetence: systematic review. British journal of surgery, 109(8), 679-685. https://doi.org/10.1093/bjs/znac116

BACKGROUND: International guidelines recommend postprocedural compression when treating symptomatic superficial venous incompetence (SVI). This updated review of RCTs investigated the requirement for postprocedural compression and how it can be appli... Read More about Compression following treatment of superficial venous incompetence: systematic review.

Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients (2022)
Journal Article
Ettelaie, C., Benelhaj, N., Featherby, S., Haque, F., Johnson, M., Cooke, J., & Maraveyas, A. (2022). Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients. Journal of Biotechnology and Biomedicine, 5(2), 78-93. https://doi.org/10.26502/jbb.2642-280050

Predicting which cancer patients are at risk of thrombosis remains a key challenge to effective thromboprophylaxis. This study was based on the hypothesis that the rapid release of TF-containing MV occurs in cancer cells that possess high levels of T... Read More about Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients.

Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process (2022)
Journal Article
Long, J., Lathan, R., Sidapra, M., Gronlund, T., Chetter, I., & on behalf of the Vascular Society of Great Britain and Ireland Wounds Special Interest Group. (2022). Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process. Journal of Vascular Societies Great Britain and Ireland, 1(4), 110-116. https://doi.org/10.54522/jvsgbi.2022.027

Background: The management of vascular wounds is often a complex and prolonged process that impacts individuals’ quality of life, is challenging for clinicians and results in a significant financial burden to the NHS. UK wound care practices vary con... Read More about Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process.

Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough (2022)
Journal Article
Dicpinigaitis, P. V., Birring, S. S., Blaiss, M., McGarvey, L. P., Morice, A. H., Pavord, I. D., …Muccino, D. (2023). Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough. Annals of Allergy, Asthma and Immunology, 130(1), 60-66. https://doi.org/10.1016/j.anai.2022.05.003

Background: The current characterization of patients with refractory or unexplained chronic cough (RCC and UCC, respectively) primarily stems from relatively small clinical studies. Objective: To report the baseline medical history and clinical chara... Read More about Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough.

Exploring hypoxic biology to improve radiotherapy outcomes (2022)
Journal Article
Li, C., Wiseman, L., Okoh, E., Lind, M., Roy, R., Beavis, A., & Monteiro dos Santos Pires, I. (2022). Exploring hypoxic biology to improve radiotherapy outcomes. Expert Reviews in Molecular Medicine, 24, Article E21. https://doi.org/10.1017/erm.2022.14

Ionising radiotherapy is a well-established, effective cancer treatment modality, whose efficacy has improved with the application of newer technological modalities. However, patient outcomes are governed and potentially limited by aspects of tumour... Read More about Exploring hypoxic biology to improve radiotherapy outcomes.

Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study (2022)
Journal Article
Prabakaran, P., Totty, J., Carradice, D., Chetter, I., & Smith, G. (in press). Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study. Journal of Wound Care,

Aims This study aimed to investigate the effects of a Single use Negative Pressure Wound Therapy (sNPWT) device upon tissue perfusion, oxygenation and pressure, in the intact skin of healthy volunteers. Methods 12 healthy volunteers wore a PIC... Read More about Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study.

Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS) (2022)
Journal Article
Cotton, S., Devereux, G., Abbas, H., Briggs, A., Campbell, K., Chaudhuri, R., …Lipworth, B. J. (2022). Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials, 23(1), Article 307. https://doi.org/10.1186/s13063-022-06226-8

Background: Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity, mortality and healthcare costs. Beta blockers are well-established drugs widely used to treat cardiovascular conditions. Observational studies consiste... Read More about Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS).