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All Outputs (79)

Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial (2020)
Journal Article
Yiasemidou, M., Mushtaq, F., Basheer, M., Galli, R., Panagiotou, D., Stock, S., …Miskovic, D. (2021). Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial. BJS Open, 5(2), Article zraa004. https://doi.org/10.1093/bjsopen/zraa004

Background It was hypothesized that preparing for a surgical procedure, taking into account individual patient characteristics, may facilitate the procedure and improve surgical quality. The aim of this study was to compare different case-specific,... Read More about Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial.

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis (2020)
Journal Article
Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 an... Read More about Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery (2020)
Journal Article
Totty, J., Moss, J. W. E., Barker, E., Mealing, S., Posnett, J., Chetter, I. C., & Smith, G. E. (in press). The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery. International wound journal, https://doi.org/10.1111/iwj.13526

Surgical site infections (SSI) substantially increase costs for healthcare providers because of additional treatments and extended patient recovery. The objective of this study was to assess the cost and health‐related quality of life impact of SSI,... Read More about The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery.

Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease (2020)
Journal Article
Helo, Y., Searle, G. E., Borghese, F., Abraham, S., & Saleem, A. (2020). Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease. EJNMMI Research, 10(1), Article 147. https://doi.org/10.1186/s13550-020-00736-9

© 2020, The Author(s). Objective: Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity of the... Read More about Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease.

Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities (2020)
Journal Article
Mohammad, M. A., Greenman, J., Maraveyas, A., & Ettelaie, C. (2020). Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities. Scientific reports, 10(1), Article 20908. https://doi.org/10.1038/s41598-020-77963-6

Tissue factor (TF) signalling has been associated with alterations in Akt activity influencing cellular survival and proliferation. TF is also shown to induce signalling through activation of the protease activated receptor (PAR)2. Seven cell lines w... Read More about Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities.

The surgical management of cutaneous abscesses: A UK cross-sectional survey (2020)
Journal Article
Thomas, O., Ramsay, A., Yiasemidou, M., Hardie, C., Ashmore, D., Macklin, C., …Jayne, D. (2020). The surgical management of cutaneous abscesses: A UK cross-sectional survey. Annals of Medicine and Surgery, 60, 654-659. https://doi.org/10.1016/j.amsu.2020.11.068

Aim Cutaneous abscesses are one of the most common acute general surgery presentations. This study aimed to understand the current practice in the management of cutaneous abscesses in the United Kingdom (UK), once the decision has been made that acu... Read More about The surgical management of cutaneous abscesses: A UK cross-sectional survey.

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome (2020)
Journal Article
Jimenez-Royo, P., Bombardieri, M., Ciurtin, C., Kostapanos, M., Tappuni, A. R., Jordan, N., …Tarzi, R. (2021). Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome. Rheumatology, 60(5), 2396-2408. https://doi.org/10.1093/rheumatology/keaa624

OBJECTIVES: To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-... Read More about Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome.

Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication (2020)
Journal Article
Pymer, S., Ibeggazene, S., Palmer, J., Smith, G. E., Carroll, S., Ingle, L., …Chetter, I. C. (2021). Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication. Journal of Cardiopulmonary Rehabilitation and Prevention, 41(3), 188-193. https://doi.org/10.1097/HCR.0000000000000551

Considering the Feasibility, Tolerability and Safety of High-Intensity Interval Training as a Novel Treatment for Patients with Intermittent Claudication. Structured Abstract Purpose: This study assessed the feasibility, tolerability, safety and... Read More about Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication.

Exercise training for intermittent claudication: A narrative review and summary of guidelines for practitioners (2020)
Journal Article
Harwood, A., Pymer, S., Ingle, L., Doherty, P., Chetter, I. C., Parmenter, B., …Tew, G. (2020). Exercise training for intermittent claudication: A narrative review and summary of guidelines for practitioners. BMJ Open Sport and Exercise Medicine, 6(1), Article e000897. https://doi.org/10.1136/bmjsem-2020-000897

Peripheral artery disease (PAD) is caused by atherosclerotic narrowing of the arteries supplying the lower limbs often resulting in intermittent claudication, evident as pain or cramping while walking. Supervised exercise training elicits clinically... Read More about Exercise training for intermittent claudication: A narrative review and summary of guidelines for practitioners.

Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations (2020)
Journal Article
Butler, A. E., Abouseif, A., Dargham, S. R., Sathyapalan, T., & Atkin, S. L. (2020). Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations. Scientific reports, 10(1), Article 18895. https://doi.org/10.1038/s41598-020-75109-2

© 2020, The Author(s). To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data... Read More about Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations.

Incomplete surgical excision of keratinocyte skin cancers: a systematic review and meta‐analysis (2020)
Journal Article
Nolan, G., Kiely, A., Totty, J., Wormald, J., Wade, R., Arbyn, M., & Jain, A. (2021). Incomplete surgical excision of keratinocyte skin cancers: a systematic review and meta‐analysis. British journal of dermatology, 184(6), 1033-1044. https://doi.org/10.1111/bjd.19660

Background Keratinocyte or nonmelanoma skin cancer (NMSC) is the commonest malignancy worldwide. The usual treatment is surgical excision. Current guidelines underestimate incomplete excision rates. Objectives We aimed to determine the risk of i... Read More about Incomplete surgical excision of keratinocyte skin cancers: a systematic review and meta‐analysis.

Recent advances in drug discovery for diabetic kidney disease (2020)
Journal Article
Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (2021). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, 16(4), 447-461. https://doi.org/10.1080/17460441.2021.1832077

Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectivenes... Read More about Recent advances in drug discovery for diabetic kidney disease.

Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure (2020)
Journal Article
Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63. https://doi.org/10.1016/j.amjcard.2020.10.034

Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized co... Read More about Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure.

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production (2020)
Journal Article
Atkinson, S. K., Morice, A. H., & Sadofsky, L. R. (2020). Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production. ERJ Open Research, 6(4), Article 00159-2020. https://doi.org/10.1183/23120541.00159-2020

Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80% of URTI cases, accompanied by heightened airway hypersensitivity, yet no effective treatmen... Read More about Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production.

Curcumin for the management of periodontal diseases: a review (2020)
Journal Article
Forouzanfar, F., Forouzanfar, A., Sathyapalan, T., Orafai, H. M., & Sahebkar, A. (2020). Curcumin for the management of periodontal diseases: a review. Current Pharmaceutical Design, 26(34), 4277-4284. https://doi.org/10.2174/1381612826666200513112607

Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receivi... Read More about Curcumin for the management of periodontal diseases: a review.