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Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire (2013)
Journal Article
Smith, J. E., Morjaria, J. B., & Morice, A. H. (2013). Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire. Cough, 9(1), Article 27. https://doi.org/10.1186/1745-9974-9-27

Background: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown... Read More about Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.

The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation (2013)
Journal Article
Souroullas, P., Barnes, R., Lane, R. A., & Chetter, I. (2014). The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation. Annals of vascular surgery, 28(5), 1166-1171. https://doi.org/10.1016/j.avsg.2013.10.017

IntroductionMorbidity and mortality after lower limb amputation (LLA) remain disappointingly high. This study aimed to assess the impact of previous ipsilateral vascular intervention on outcomes after major LLA.MethodsProspective data were collected... Read More about The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation.

Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. (2013)
Journal Article
Vanicek, N., King, S. A., Gohil, R., Chetter, I. C., & Coughlin, P. A. (2013). Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. Journal of Visualized Experiments, Article e51077. https://doi.org/10.3791/51077

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic conditions. As part of a diagnostic assessment, the early detection of postural deficits is importan... Read More about Computerized dynamic posturography for postural control assessment in patients with intermittent claudication..

Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Gohil, R., Souroullas, P., Khan, J., …Chetter, I. C. (2014). Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair. Annals of vascular surgery, 28(1), 74-79. https://doi.org/10.1016/j.avsg.2013.09.001

Background Aerobic fitness is an important predictor of postoperative outcome in major surgery. In this study, we assess the effects of a period of preoperative exercise on aerobic fitness as measured by cardiopulmonary exercise testing (CPET) in pa... Read More about Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair.

Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication (2013)
Journal Article
Shahin, Y., Barnes, R., Barakat, H., & Chetter, I. C. (2013). Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication. Atherosclerosis, 231(2), 283-290. https://doi.org/10.1016/j.atherosclerosis.2013.09.037

Objective The aim of this meta-analysis was to investigate the effect of angiotensin converting enzyme (ACE) inhibitors on maximum walking distance (MWD), pain-free walking distance (PFWD) and ankle brachial pressure index (ABPI) in patients with in... Read More about Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication.

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles (2013)
Journal Article
Collier, M. E. W., Ettelaie, C., & Maraveyas, A. (2014). Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles. Thrombosis and haemostasis, 111(4), 647-655. https://doi.org/10.1160/TH13-09-0769

We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF. Since the cytoskeletal protein filamin-A is known to bind to the cytoplasmi... Read More about Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles.

Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Sedman, P., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls. Obesity Surgery, 24(3), 349-358. https://doi.org/10.1007/s11695-013-1100-2

Background Insulin resistance (IR) after bariatric surgery is significantly lower than controls matched for bodymass index (BMI) and is indistinguishable from lean subjects however it is not known if this is the same for associated cardiovascular ris... Read More about Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls.

Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Chetter, I., & McCollum, P. (2014). Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience. Annals of vascular surgery, 28(1), 80-86. https://doi.org/10.1016/j.avsg.2013.07.006

Background The purpose of this study was to evaluate morbidity, mortality, and survival in octogenarians undergoing open repair of ruptured abdominal aortic aneurysms (RAAAs) in comparison to younger patients.MethodsThis investigation was a retrospe... Read More about Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience.

Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009 (2013)
Journal Article
Lüchtenborg, M., Riaz, S. P., Lim, E., Page, R., Baldwin, D. R., Jakobsen, E., …Møller, H. (2014). Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009. Thorax, 69(3), 269-273. https://doi.org/10.1136/thoraxjnl-2013-203884

Introduction: Chemotherapy or chemoradiotherapy is the recommended treatment for small cell lung cancer (SCLC), except in stage I disease where clinical guidelines state there may be a role for surgery based on favourable outcomes in case series. Evi... Read More about Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009.

Cough in the Elderly Population: Relationships with Multiple Comorbidity (2013)
Journal Article
Song, W. J., Morice, A. H., Kim, M. H., Lee, S. E., Jo, E. J., Lee, S. M., …Chang, Y. S. (2013). Cough in the Elderly Population: Relationships with Multiple Comorbidity. PLoS ONE, 8(10), Article e78081. https://doi.org/10.1371/journal.pone.0078081

Background:The epidemiology of cough in the elderly population has not been studied comprehensively. The present study aimed to investigate the epidemiology of cough in a community elderly population, particularly in relation with their comorbidity.M... Read More about Cough in the Elderly Population: Relationships with Multiple Comorbidity.

Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension? (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?. Microvascular Research, 90, 135-137. https://doi.org/10.1016/j.mvr.2013.09.002

Introduction: Acute rises in pulmonary artery pressures are associated with a significant mortality and morbidity due to the significant strain on the right ventricle. Although hydrogen sulphide (H2S) has been studied for its potential role in the sy... Read More about Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?.

High procedure volume is strongly associated with improved survival after lung cancer surgery (2013)
Journal Article
Lüchtenborg, M., Riaz, S. P., Coupland, V. H., Lim, E., Jakobsen, E., Krasnik, M., …Møller, H. (2013). High procedure volume is strongly associated with improved survival after lung cancer surgery. Journal of Clinical Oncology, 31(25), 3141-3146. https://doi.org/10.1200/JCO.2013.49.0219

Purpose Studies have reported an association between hospital volume and survival for non–small-cell lung cancer (NSCLC). We explored this association in England, accounting for case mix and propensity to resect. Methods We analyzed data on 134,293... Read More about High procedure volume is strongly associated with improved survival after lung cancer surgery.

A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Smithson, J. A. J., Vince, R. V., Coady, A. M., Ajjan, R., …Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), 843-849. https://doi.org/10.1111/cen.12258

Background Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. Objectiv... Read More about A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.

Hypoxic pulmonary vasoconstriction in humans (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hypoxic pulmonary vasoconstriction in humans. Biomed research international, 2013, Article 623684. https://doi.org/10.1155/2013/623684

Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although consid... Read More about Hypoxic pulmonary vasoconstriction in humans.

Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity (2013)
Journal Article
Collier, M. E. W., Mah, P., Xiao, Y., Maraveyas, A., & Ettelaie, C. (2013). Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity. Thrombosis and haemostasis, 110(5), 966-976. https://doi.org/10.1160/TH13-01-0055

In this study the uptake of tissue factor (TF)-positive microparticles by endothelial cells and the recycling of the TF component were examined. Human dermal blood endothelial cells (HDBEC) were incubated with microparticles derived from cancer cell... Read More about Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity.

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication (2013)
Journal Article
Gohil, R. A., Mockford, K. A., Mazari, F. A., Khan, J. A., Van Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2013). Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication. Journal of vascular surgery, 58(6), 1533-1539. https://doi.org/10.1016/j.jvs.2013.05.106

Objective The aim of this study was to identify whether revascularization by percutaneous transluminal angioplasty (PTA) for patients with intermittent claudication improved measures of functional performance including balance. Methods A prospective... Read More about Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication.

Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease (2013)
Journal Article
Mazari, F. A. K., Khan, J. A., Carradice, D., Samuel, N., Gohil, R., McCollum, P. T., & Chetter, I. C. (2013). Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease. British journal of surgery, 100(9), 1172-1179. https://doi.org/10.1002/bjs.9200

BackgroundThe aim was to compare costs and utilities of percutaneous transluminal angioplasty (PTA), a supervised exercise programme (SEP) and combined treatment (PTA + SEP) in patients with intermittent claudication (IC) to establish the most cost-e... Read More about Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease.

Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication (2013)
Journal Article
Shahin, Y., Cockcroft, J. R., & Chetter, I. C. (2013). Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication. British journal of surgery, 100(9), 1154-1163. https://doi.org/10.1002/bjs.9198

BackgroundThe aim was to investigate the effect of ramipril on clinical parameters in patients with peripheral arterial disease.MethodsPatients with intermittent claudication were randomized to receive ramipril or placebo for 24 weeks in a double-bli... Read More about Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication.