Skip to main content

Research Repository

Advanced Search

All Outputs (52)

High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study (2023)
Journal Article
Desai, S. R., Sivarasan, N., Johannson, K. A., George, P. M., Culver, D. A., Devaraj, A., Lynch, D. A., Milne, D., Renzoni, E., Nunes, H., Sverzellati, N., Spagnolo, P., Baughman, R. P., Yadav, R., Piciucchi, S., Walsh, S. L. F., Kouranos, V., Wells, A. U., Anderson, A., Morgenthau, A., …Inoue, Y. (in press). High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study. The lancet. Respiratory medicine, https://doi.org/10.1016/S2213-2600%2823%2900267-9

One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treat... Read More about High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study.

Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis (2023)
Journal Article
Mohamed, E., García Martínez, D. J., Hosseini, M. S., Yoong, S. Q., Fletcher, D., Hart, S., & Guinn, B. A. (2024). Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis. Carcinogenesis, 45(1-2), Article bgad091. https://doi.org/10.1093/carcin/bgad091

Lung cancer (LC) causes few symptoms in the earliest stages, leading to one of the highest mortality rates among cancers. Low-dose computerised tomography (LDCT) is used to screen high-risk individuals, reducing the mortality rate by 20%. However, LD... Read More about Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis.

Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis (2023)
Journal Article
Batten, L., Sathyapalan, T., & Palmer, T. M. (2023). Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis. International Journal of Molecular Sciences, 24(24), Article 17465. https://doi.org/10.3390/ijms242417465

This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk. The leading causes of death in people with diabetes are strokes and cardiovascular disease. Significant mo... Read More about Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis.

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., Smith, G. E., Carradice, D., Chetter, I. C., & Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.

Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials (2023)
Journal Article
Molica, S., & Allsup, D. (2023). Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials. Expert Review of Anticancer Therapy, https://doi.org/10.1080/14737140.2023.2288899

Introduction: Chronic lymphocytic leukemia (CLL) management has witnessed a transformative shift with the advent of time-limited venetoclax and anti-CD20 monoclonal antibody (mAb) regimens, as exemplified by the groundbreaking MURANO and CLL14 trials... Read More about Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials.

Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (in press). Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions. Hematological Oncology, https://doi.org/10.1002/hon.3238

In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53 function due to genetic abnormalities remains a significant challenge. This is because even targeted agents, which are currently the mainstay of treatment for C... Read More about Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions.

Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study (2023)
Journal Article
Song, W. J., Dupont, L., Birring, S. S., Chung, K. F., Dąbrowska, M., Dicpinigaitis, P., Ribas, C. D., Fontana, G., Gibson, P. G., Guilleminault, L., Hull, J. H., Idzko, M., Kardos, P., Kim, H. J., Lai, K., Lavorini, F., Millqvist, E., Morice, A. H., Niimi, A., Parker, S. M., …McGarvey, L. P. (2023). Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study. ERJ Open Research, 9(6), Article 00618-2023. https://doi.org/10.1183/23120541.00618-2023

Background Current guidelines on the management of chronic cough do not provide recommendations for the operation of specialist cough clinics. The objective of the present study was to develop expert consensus on goals and standard procedures for spe... Read More about Consensus goals and standards for specialist cough clinics: the NEUROCOUGH international Delphi study.

Molecular mechanisms of action of negative pressure wound therapy: A systematic review (2023)
Journal Article
Ravindhran, B., Schafer, N., Howitt, A., Carradice, D., Smith, G., & Chetter, I. (2023). Molecular mechanisms of action of negative pressure wound therapy: A systematic review. Expert Reviews in Molecular Medicine, 25, Article e29. https://doi.org/10.1017/erm.2023.24

Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current e... Read More about Molecular mechanisms of action of negative pressure wound therapy: A systematic review.

Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1270949. https://doi.org/10.3389/fendo.2023.1270949

Introduction: Polychlorinated biphenyls (PCBs) are organic lipophilic pollutants that accumulate in the body. Previous research has linked PCBs with menstrual function; therefore, this study was undertaken to investigate the correlation of PCBs with... Read More about Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome.

Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series (2023)
Journal Article
Brown, M., O’Connor, D., Turkington, R., Eatock, M., Vince, R., Hulme, C., Bowdery, R., Robinson, R., Wadsley, J., Maraveyas, A., & Prue, G. (2023). Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series. BMC Sports Science, Medicine and Rehabilitation, 15(1), Article 116. https://doi.org/10.1186/s13102-023-00722-3

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise tra... Read More about Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series.

High-intensity interval training in patients with intermittent claudication (2023)
Presentation / Conference Contribution
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., Ibeggazene, S., Huang, C., Twiddy, M., Nicholls, A. R., Ingle, L., Carroll, S., He, H., Long, J., Rooms, M., & Chetter, I. C. High-intensity interval training in patients with intermittent claudication. Presented at 2022 Vascular Society of Great Britain and Ireland Annual Scientific Meeting, Brighton, UK

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome (2023)
Journal Article
Brennan, E., Butler, A. E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1233484. https://doi.org/10.3389/fendo.2023.1233484

Introduction: Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated with polycystic ovary syndrome (PCOS) and shown to affect microRNA (miRNA) expression. This work ai... Read More about Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome.

Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit (2023)
Journal Article
Mark-Wagstaff, C., Deshmukh, H., Wilmot, E. G., Walker, N., Barnes, D., Parfitt, V., Saunders, S., Gregory, R., Choudhary, P., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2024). Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit. Diabetes, Obesity and Metabolism, 26(1), 46-53. https://doi.org/10.1111/dom.15283

Aim: Frequent hypoglycaemia results in disruption to usual hypoglycaemic autonomic responses leading to impaired awareness of hypoglycaemia, which is associated with an increased risk of severe hypoglycaemia requiring third-party assistance (SH). The... Read More about Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit.

Association of polychlorinated biphenyls with vitamin D in female subjects (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association of polychlorinated biphenyls with vitamin D in female subjects. Environmental Research, 233, Article 116465. https://doi.org/10.1016/j.envres.2023.116465

Introduction: Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest associatio... Read More about Association of polychlorinated biphenyls with vitamin D in female subjects.

A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair (2023)
Presentation / Conference Contribution
Sethi, S., Ravindhran, B., Long, J., Gurung, R., Huang, C., Smith, G. E., Carradice, D., Wallace, T., Ibeggazene, S., Chetter, I. C., & Pymer, S. A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair. Presented at 2023 Vascular Annual Meeting of the Society for Vascular Surgery, National Harbor, Maryland

Objective: A preoperative supervised exercise program (SEP) improves cardiorespiratory fitness and perioperative outcomes for patients undergoing elective abdominal aortic aneurysm (AAA) repair. The aim of this study was to assess the effect of a pre... Read More about A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair.

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial (2023)
Journal Article
Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., Vitale, S. G., Rigby, A., Vince, R. V., Reid, M., & Sathyapalan, T. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial. Nutrients, 15(18), Article 3872. https://doi.org/10.3390/nu15183872

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women wi... Read More about The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial.

Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction (2023)
Journal Article
Bravington, A., Obita, G., Baddeley, E., Johnson, M., Murtagh, F., Currow, D., Boland, E., Nelson, A., Seddon, K., Oliver, A., Noble, S., & Boland, J. (2023). Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction. PLoS ONE, 18(8), Article e0289501. https://doi.org/10.1371/journal.pone.0289501

Background: Malignant bowel obstruction is experienced by 15% of people with advanced cancer, preventing them from eating and drinking and causing pain, nausea and vomiting. Surgery is not always appropriate. Management options include tube or stent... Read More about Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction.

New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study (2023)
Journal Article
Zhang, M., Morice, A. H., Si, F., Zhang, L., Chen, Q., Wang, S., Zhu, Y., Xu, X., Yu, L., & Qiu, Z. (2023). New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study. Allergy Asthma and Immunology Research, 15(6), 795-811. https://doi.org/10.4168/aair.2023.15.6.795

Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifesta... Read More about New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Presented at AACR Special Conference on Advances in Kidney Cancer Research, Austin, Texas, U.S.A

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.