Skip to main content

Research Repository

Advanced Search

All Outputs (756)

Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups (2022)
Journal Article
Yale, J. F., Bodholdt, U., Catarig, A. M., Catrina, S., Clark, A., Ekberg, N. R., …Rudofsky, G. (2022). Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups. BMJ Open Diabetes Research and Care, 10(2), Article e002619. https://doi.org/10.1136/bmjdrc-2021-002619

INTRODUCTION: This post hoc pooled analysis of four real-world studies (SURE Canada, Denmark/Sweden, Switzerland and UK) aimed to characterize the use of once-weekly (OW) semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in patients... Read More about Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups.

Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy (2022)
Journal Article
Bibak, B., Shakeri, F., Keshavarzi, Z., Mollazadeh, H., Javid, H., Jalili-Nik, M., …Sahebkar, A. (2022). Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy. Current medicinal chemistry, 29(26), 4507-4528. https://doi.org/10.2174/0929867329666220224112811

The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by re... Read More about Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy.

FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis (2022)
Journal Article
Blissett, R., Blissett, D., Levrat-Guillen, F., Deshmukh, H., Wilmot, E. G., Ryder, R. E., …Sathyapalan, T. (2022). FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis. BMJ Open Diabetes Research and Care, 10(2), Article e002580. https://doi.org/10.1136/bmjdrc-2021-002580

INTRODUCTION: This study aims to estimate the budget impact of increased uptake of the FreeStyle Libre Flash Glucose Monitoring system in people with type 1 diabetes mellitus (T1DM) in the UK. RESEARCH DESIGN AND METHODS: A budget impact model was de... Read More about FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis.

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders (2022)
Journal Article
Shakeri, F., Bibak, B., Safdari, M. R., Keshavarzi, Z., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2022). Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders. Current medicinal chemistry, 29(16), 2878-2890. https://doi.org/10.2174/0929867329666220210145033

There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The... Read More about Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders.

A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome (2022)
Journal Article
Brennan, E., Kumar, N., Drage, D. S., Cunningham, T. K., Sathyapalan, T., Mueller, J. F., & Atkin, S. L. (2022). A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome. Journal of Environmental Science and Health , Part C: Toxicology and Carcinogenesis, 40(1), 86-105. https://doi.org/10.1080/26896583.2022.2043135

Polychlorinated biphenyls (PCBs) are a class of environmental pollutants with a long half-life that sequester in fat. Women with polycystic ovarian syndrome (PCOS) may represent a sensitive subgroup to endogenous exposure to PCBs because of associate... Read More about A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome.

Postradioiodine Graves' management: The PRAGMA study (2022)
Journal Article
Perros, P., Basu, A., Boelaert, K., Dayan, C., Vaidya, B., Williams, G. R., …Karavitaki, N. (2022). Postradioiodine Graves' management: The PRAGMA study. Clinical Endocrinology, https://doi.org/10.1111/cen.14719

Objective: Thyroid status in the months following radioiodine (RI) treatment for Graves' disease can be unstable. Our objective was to quantify frequency of abnormal thyroid function post-RI and compare effectiveness of common management strategies.... Read More about Postradioiodine Graves' management: The PRAGMA study.

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis (2022)
Working Paper
Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Increasing age is the main risk factor for chronic lung diseases (CLD) including idiopathic pulmonary fibrosis (IPF). Halting or reversing progression of IPF remains an unmet clinical need due to limited knowledge of underlying mechanisms. In particu... Read More about Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis.

Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology (2022)
Journal Article
Sahebkar, A., Sathyapalan, T., Guest, P. C., & Barreto, G. E. (2022). Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology. Biomedicine and Pharmacotherapy, 148, Article 112770. https://doi.org/10.1016/j.biopha.2022.112770

Traumatic brain injury (TBI) affects approximately 50% of the world population at some point in their lifetime. To date, there are no effective treatments as most of the damage occurs due to secondary effects through a variety of pathophysiological p... Read More about Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology.

Treatment of chronic cough: P2X3 receptor antagonists and beyond (2022)
Journal Article
Sykes, D. L., Zhang, M., & Morice, A. H. (2022). Treatment of chronic cough: P2X3 receptor antagonists and beyond. Pharmacology and Therapeutics, 237, Article 108166. https://doi.org/10.1016/j.pharmthera.2022.108166

For years chronic cough (CC) has presented an enormous physical, psychological, and social burden on those who experience it, with no approved pharmacological therapies to assuage their symptoms. With our improved understanding of the pathophysiologi... Read More about Treatment of chronic cough: P2X3 receptor antagonists and beyond.

A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging (2022)
Journal Article
Mesgari, M., Aalami, A. H., Sathyapalan, T., & Sahebkar, A. (2022). A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging. Bioinorganic Chemistry and Applications, 2022, Article 7557825. https://doi.org/10.1155/2022/7557825

Background. Food nanopackaging helps maintain food quality against physical, chemical, and storage instability factors. Copper oxide nanoparticles (CuONPs) can improve biopolymers' mechanical features and barrier properties. This will lead to antimic... Read More about A Comprehensive Review of the Development of Carbohydrate Macromolecules and Copper Oxide Nanocomposite Films in Food Nanopackaging.

Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature (2022)
Journal Article
Hatamipour, M., Hadizadeh, F., Jaafari, M. R., Khashyarmanesh, Z., Sathyapalan, T., & Sahebkar, A. (2022). Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature. Current medicinal chemistry, 29(8), 1459-1471. https://doi.org/10.2174/0929867328666210910141316

BACKGROUND: Curcuminoids, flavoring, and coloring agents in food have potent antioxidant, anti-tumor activity, and anti-inflammatory effects. However, they are rapidly metabolized to lesser active metabolites. Therefore, various studies have been con... Read More about Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature.

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials (2022)
Journal Article
McGarvey, L. P., Birring, S. S., Morice, A. H., Dicpinigaitis, P. V., Pavord, I. D., Schelfhout, J., …Smith, J. A. (2022). Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet, 399(10328), 909-923. https://doi.org/10.1016/S0140-6736%2821%2902348-5

Background: Gefapixant is an oral P2X3 receptor antagonist that has previously shown efficacy and safety in refractory chronic cough and unexplained chronic cough. We therefore aim to confirm the efficacy and safety of gefapixant in participants with... Read More about Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.

The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery (2022)
Journal Article
Jamialahmadi, T., Nematy, M., Abdalla, M., Jangjoo, A., Goshayeshi, L., Kroh, M., …Sahebkar, A. (2022). The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery. Journal of Nutrition and Metabolism, 2022, Article 7319742. https://doi.org/10.1155/2022/7319742

Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity... Read More about The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.

Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization. Metabolites, 12(3), Article 196. https://doi.org/10.3390/metabo12030196

Development of type-2 diabetes(T2D) is preceded by β-cell dysfunction and loss. How-ever, accurate measurement of β-cell function remains elusive. Biomarkers have been reported to predict β-cell functional decline but require validation. Therefore, w... Read More about Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization.

Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis (2022)
Journal Article
Akbari, A., Rafiee, M., Sathyapalan, T., & Sahebkar, A. (2022). Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis. Journal of Diabetes Research, 2022, Article 7520632. https://doi.org/10.1155/2022/7520632

Background: Several trials have assessed the antihyperglycemic effects of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM). We conducted a quantitative analysis to assess the impact of SGLT2is on ser... Read More about Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women (2022)
Journal Article
Ramanjaneya, M., Abdalhakam, I., Bettahi, I., Bensila, M., Jerobin, J., Aye, M. M., …Abou-Samra, A. B. (2022). Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women. Frontiers in endocrinology, 12, Article 740703. https://doi.org/10.3389/fendo.2021.740703

Background: The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, al... Read More about Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication (2022)
Journal Article
Ibeggazene, S., Cai, P. L., Smith, G. E., Ibbegazene, S., Stirrup, A., Pymer, S., …Chetter, I. C. (in press). The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication. Vascular, https://doi.org/10.1177/17085381211059665

Background: The screening and diagnosis of intermittent claudication is a challenging process and often relies on the expertise of specialist vascular clinicians. We sought to investigate the diagnostic performance of the Edinburgh Claudication Quest... Read More about The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication.

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.