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Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device (2021)
Journal Article
Richardson, S., Iles, A., Rotchell, J. M., Charlson, T., Hanson, A., Lorch, M., & Pamme, N. (2021). Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device. PLoS ONE, 16(12), Article e0260102. https://doi.org/10.1371/journal.pone.0260102

Contamination of waterways is of increasing concern, with recent studies demonstrating elevated levels of antibiotics, antidepressants, household, agricultural and industrial chemicals in freshwater systems. Thus, there is a growing demand for method... Read More about Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.

Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs) (2020)
Journal Article
Abdulsattar, J. O., Hadi, H., Richardson, S., Iles, A., & Pamme, N. (2020). Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs). Analytica Chimica Acta, 1136, 196-204. https://doi.org/10.1016/j.aca.2020.09.045

There is growing demand for simple to operate, sensitive, on-site quantitative assays to investigate concentrations of drug molecules in pharmaceutical preparations for quality assurance. Here, we report on the development of two colorimetric analysi... Read More about Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs).

Microfluidic-Based Electrochemical Immunosensing of Ferritin (2020)
Journal Article
Garg, M., Christensen, M. G., Iles, A., Sharma, A. L., Singh, S., & Pamme, N. (2020). Microfluidic-Based Electrochemical Immunosensing of Ferritin. Biosensors, 10(8), Article 91. https://doi.org/10.3390/bios10080091

Ferritin is a clinically important biomarker which reflects the state of iron in the body and is directly involved with anemia. Current methods available for ferritin estimation are generally not portable or they do not provide a fast response. To co... Read More about Microfluidic-Based Electrochemical Immunosensing of Ferritin.

Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers (2019)
Journal Article
Gómez-Pastora, J., Amiri Roodan, V., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Iles, A., …Ortiz, I. (2019). Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers. Journal of physical chemistry. C, 123(15), 10065-10080. https://doi.org/10.1021/acs.jpcc.9b01393

Copyright © 2019 American Chemical Society. In this study, a computational fluid dynamics approach is implemented to investigate the dynamic behavior of continuous-flow droplet microfluidics. The developed approach predicts both droplet generation an... Read More about Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers.

A microfluidic atmospheric-pressure plasma reactor for water treatment (2019)
Journal Article
Patinglag, L., Sawtell, D., Iles, A., Melling, L. M., & Shaw, K. J. (2019). A microfluidic atmospheric-pressure plasma reactor for water treatment. Plasma Chemistry and Plasma Processing, 39(3), 561–575. https://doi.org/10.1007/s11090-019-09970-z

A dielectric barrier discharge microfluidic plasma reactor, operated at atmospheric pressure, was studied for its potential to treat organic contaminants in water. Microfluidic technology represents a compelling approach for plasma-based water treatm... Read More about A microfluidic atmospheric-pressure plasma reactor for water treatment.

CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams (2018)
Conference Proceeding
Gómez-Pastora, J., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Bringas, E., Iles, A., …Ortiz, I. (2018). CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams. In Biotech, biomaterials and biomedical: TechConnect briefs 2018 (182-185)

© 2018 OOSV. All rights reserved. The use of droplet-based microfluidic systems has increased in the last decade due to the advantages these systems present such as compatibility with many chemical and biological reagents, capability of performing a... Read More about CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams.

Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification (2018)
Journal Article
Gómez-Pastora, J., González-Fernández, C., Real, E., Iles, A., Bringas, E., Furlani, E. P., & Ortiz, I. (2018). Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification. Lab on a chip, 18(11), 1593-1606. https://doi.org/10.1039/c8lc00396c

Magnetic beads can be functionalized to capture and separate target pathogens from blood for extracorporeal detoxification. The beads can be magnetically separated from a blood stream and collected into a coflowing buffer solution using a two-phase l... Read More about Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification.

Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device (2011)
Journal Article
Robert, D., Pamme, N., Conjeaud, H., Gazeau, F., Iles, A., & Wilhelm, C. (2011). Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device. Lab on a chip, 11(11), 1902-1910. https://doi.org/10.1039/c0lc00656d

Magnetically labelled cells are finding a wealth of applications for in vitro analysis as well as in vivo treatments. Sorting of cells into subpopulations based on their magnetite loading is an important step in such procedures. Here, we study the so... Read More about Cell sorting by endocytotic capacity in a microfluidic magnetophoresis device.

Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles (2010)
Journal Article
Vojtíšek, M., Iles, A., & Pamme, N. (2010). Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles. Biosensors & bioelectronics, 25(9), 2172-2176. https://doi.org/10.1016/j.bios.2010.01.034

DNA hybridisation is an important tool for bioanalytical research and clinical diagnostics; conventional methods, however, require long incubation times and numerous washing steps, rendering the procedure time consuming and labour intensive. In this... Read More about Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles.

Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow (2009)
Journal Article
Peyman, S. A., Iles, A., & Pamme, N. (2009). Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow. Lab on a chip, 9(21), 3110-3117. https://doi.org/10.1039/b904724g

An extremely versatile microfluidic device is demonstrated in which multi-step (bio) chemical procedures can be performed in continuous flow. The system operates by generating several co-laminar flow streams, which contain reagents for specific (bio)... Read More about Mobile magnetic particles as solid-supports for rapid surface-based bioanalysis in continuous flow.

Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices (2009)
Journal Article
Peyman, S. A., Kwan, E. Y., Margarson, O., Iles, A., & Pamme, N. (2009). Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices. Journal of Chromatography A, 1216(52), 9055-9062. https://doi.org/10.1016/j.chroma.2009.06.039

We report the exploration of diamagnetic repulsion forces for the selective manipulation of microparticles inside microfluidic devices. Diamagnetic materials such as polymers are repelled from magnetic fields, an effect greatly enhanced by suspending... Read More about Diamagnetic repulsion—A versatile tool for label-free particle handling in microfluidic devices.

Rapid on-chip multi-step (bio)chemical procedures in continuous flow - manoeuvring particles through co-laminar reagent streams (2008)
Journal Article
Peyman, S. A., Iles, A., & Pamme, N. (2008). Rapid on-chip multi-step (bio)chemical procedures in continuous flow - manoeuvring particles through co-laminar reagent streams. Chemical communications : Chem comm / the Royal Society of Chemistry, 1220-1222. https://doi.org/10.1039/b716532c

We introduce a novel and extremely versatile microfluidic platform in which tedious multi-step biochemical processes can be performed in continuous flow within a fraction of the time required for conventional methods.