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Removal of Human Leukemic Cells from Peripheral Blood Mononuclear Cells by Cell Recognition Chromatography with Size Matched Particle Imprints (2020)
Journal Article
Chester, R., Das, A. A. K., Medlock, J., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2020). Removal of Human Leukemic Cells from Peripheral Blood Mononuclear Cells by Cell Recognition Chromatography with Size Matched Particle Imprints. ACS Applied Bio Materials, 3(2), 789-800. https://doi.org/10.1021/acsabm.9b00770

We report a cell recognition chromatography approach for blood cancer cell separation from healthy peripheral blood mononuclear cells (PBMCs) based on sizematched functionalized particle imprints. Negative imprints were prepared from layers of 15 μm... Read More about Removal of Human Leukemic Cells from Peripheral Blood Mononuclear Cells by Cell Recognition Chromatography with Size Matched Particle Imprints.

Surface-Modified Zinc Oxide Nanoparticles for Antialgal and Antiyeast Applications (2020)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2020). Surface-Modified Zinc Oxide Nanoparticles for Antialgal and Antiyeast Applications. ACS Applied Nano Materials, 3(1), 440-451. https://doi.org/10.1021/acsanm.9b02045

We explored the factors and mechanisms of the anti-yeast and anti-algal effect of zinc oxide nanoparticles (ZnONPs) coated with zinc sulfide (ZnS), silica (SiO2), poly(sodium 4-styrene sulfonate) sodium salt (PSS) and poly(allylamine hydrochloride) (... Read More about Surface-Modified Zinc Oxide Nanoparticles for Antialgal and Antiyeast Applications.

Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints (2019)
Journal Article
Das, A. A., Remaud, P., Medlock, J., Das, A. A. K., Allsup, D. J., Madden, L. A., …Paunov, V. N. (2019). Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints. Materials Chemistry Frontiers, 4(1), 197-205. https://doi.org/10.1039/c9qm00531e

We report a new approach for separation of blood cancer cells from healthy white blood cells based on cell recognition by surface functionalised particle imprints. We prepared polymeric particle imprints from a layer of suspension of monodisperse PMM... Read More about Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints.

"Ghost" silica nanoparticles of "host"-inherited antibacterial action (2019)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2019). "Ghost" silica nanoparticles of "host"-inherited antibacterial action. ACS Applied Materials & Interfaces, 11(42), 38519−38530. https://doi.org/10.1021/acsami.9b14403

Copyright © 2019 American Chemical Society. We fabricated surface-rough mesoporous silica nanoparticles ("ghost" SiO2NPs) by using composite mesoporous copper oxide nanoparticles ("host" CuONPs) as templates, which allowed us to mimic their surface m... Read More about "Ghost" silica nanoparticles of "host"-inherited antibacterial action.

Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions (2019)
Journal Article
Celik, S., Dominici, S., Filby, B., Das, A., Madden, L. A., & Paunov, V. N. (2019). Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions. Biomimetics, 4(3), Article 50. https://doi.org/10.3390/biomimetics4030050

Most current methods for the preparation of tissue spheroids require complex materials, involve tedious physical steps and are generally not scalable. We report a novel alternative, which is both inexpensive and up-scalable, to produce large quantiti... Read More about Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions.

Controlling the antimicrobial action of surface modified magnesium hydroxide nanoparticles (2019)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2019). Controlling the antimicrobial action of surface modified magnesium hydroxide nanoparticles. Biomimetics, 4(2), Article 41. https://doi.org/10.3390/biomimetics4020041

Magnesium hydroxide nanoparticles (Mg(OH)2NPs) have recently attracted significant attention due to their wide applications as environmentally friendly antimicrobial nanomaterials, with potentially low toxicity and low fabrication cost. Here, we desc... Read More about Controlling the antimicrobial action of surface modified magnesium hydroxide nanoparticles.

Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action (2019)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2019). Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action. Nanoscale advances, 1(6), 2323-2336. https://doi.org/10.1039/c9na00099b

© 2019 The Royal Society of Chemistry. We have developed and tested copper oxide nanoparticles (CuONPs) grafted with (3-glycidyloxypropyl)trimethoxysilane (GLYMO) and coupled with 4-hydroxyphenylboronic acid (4-HPBA), which provides a very strong boo... Read More about Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action.

Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood (2019)
Journal Article
Das, A. A., Medlock, J., Liang, H., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2019). Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood. Journal of Materials Chemistry B, 7(22), 3497-3504. https://doi.org/10.1039/c9tb00679f

We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-ce... Read More about Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood.

Boosting the antimicrobial action of vancomycin formulated in shellac nanoparticles of dual-surface functionality (2019)
Journal Article
Al-Obaidy, S. S., Halbus, A. F., Greenway, G. M., & Paunov, V. N. (2019). Boosting the antimicrobial action of vancomycin formulated in shellac nanoparticles of dual-surface functionality. Journal of Materials Chemistry B, 7(19), 3119-3133. https://doi.org/10.1039/c8tb03102a

We report a strong amplification of the antimicrobial action of vancomycin (VCM) encapsulated in shellac nanoparticles (NPs) with dual surface functionalisation. These shellac nanocarriers for VCM were produced in two steps: (i) a pH drop from aqueou... Read More about Boosting the antimicrobial action of vancomycin formulated in shellac nanoparticles of dual-surface functionality.

Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers (2019)
Journal Article
Gómez-Pastora, J., Amiri Roodan, V., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Iles, A., …Ortiz, I. (2019). Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers. Journal of physical chemistry. C, 123(15), 10065-10080. https://doi.org/10.1021/acs.jpcc.9b01393

Copyright © 2019 American Chemical Society. In this study, a computational fluid dynamics approach is implemented to investigate the dynamic behavior of continuous-flow droplet microfluidics. The developed approach predicts both droplet generation an... Read More about Two-step numerical approach to predict ferrofluid droplet generation and manipulation inside multilaminar flow chambers.

Hierarchically structured composites and porous materials from soft templates: fabrication and applications (2019)
Journal Article
Thompson, B. R., Horozov, T. S., Stoyanov, S. D., & Paunov, V. N. (in press). Hierarchically structured composites and porous materials from soft templates: fabrication and applications. Journal of Materials Chemistry A, 7(14), 8030-8049. https://doi.org/10.1039/c8ta09750j

Recent experimental methods for fabrication of hierarchically porous and structured composites are reviewed. The main focus is on recent examples of how different soft templating materials, like emulsions, surfactant phases, breath figures, biologica... Read More about Hierarchically structured composites and porous materials from soft templates: fabrication and applications.

Strongly Enhanced Antibacterial Action of Copper Oxide Nanoparticles with Boronic Acid Surface Functionality (2019)
Journal Article
Halbus, A. F., Horozov, T. S., & Paunov, V. N. (2019). Strongly Enhanced Antibacterial Action of Copper Oxide Nanoparticles with Boronic Acid Surface Functionality. ACS Applied Materials & Interfaces, 11(13), 12232-12243. https://doi.org/10.1021/acsami.8b21862

Copper oxide nanoparticles (CuONPs) have been widely recognized as good antimicrobial agents but are heavily regulated due to environmental concerns of their postuse. In this work, we have developed and tested a novel type of formulation for copper o... Read More about Strongly Enhanced Antibacterial Action of Copper Oxide Nanoparticles with Boronic Acid Surface Functionality.

Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine (2018)
Journal Article
Al-Obaidy, S. S., Greenway, G. M., & Paunov, V. N. (2019). Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine. Nanoscale advances, 1(2), 858-872. https://doi.org/10.1039/c8na00121a

We have developed highly efficient antimicrobial nanocarriers for berberine (BRB) based on shellac nanoparticles (NPs) which were surface-functionalised with a surface active polymer, Poloxamer 407 (P407), and the cationic surfactant octadecyltrimeth... Read More about Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine.

Microcapsules as assay compartments formed through layer-by-layer deposition (2018)
Journal Article
Alorabi, A. Q., Tarn, M. D., Thomas, M., Paunov, V. N., & Pamme, N. (2018). Microcapsules as assay compartments formed through layer-by-layer deposition. Analytical Methods, 10(44), 5335-5340. https://doi.org/10.1039/c8ay02012d

We investigate the potential of using microcapsules, generated through layer-by-layer assembly, as reaction compartments for bioassays. A streptavidin-biotin and an esterase-fluorescein diacetate (FDA) assay were employed for proof-of-concept. Strept... Read More about Microcapsules as assay compartments formed through layer-by-layer deposition.

Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers (2018)
Journal Article
Al-Awady, M. J., Weldrick, P. J., Hardman, M. J., Greenway, G. M., & Paunov, V. N. (2018). Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers. Materials Chemistry Frontiers, 2(11), 2032-2044. https://doi.org/10.1039/c8qm00343b

We have developed and tested a novel functionalised nanocarrier for chlorhexidine (CHX) which provides a very strong enhancement of its antimicrobial action. The nanocarrier was based on lightly-cross-linked acrylate copolymer nanogel particles loade... Read More about Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers.

CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams (2018)
Conference Proceeding
Gómez-Pastora, J., Karampelas, I. H., Alorabi, A. Q., Tarn, M. D., Bringas, E., Iles, A., …Ortiz, I. (2018). CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams. In Biotech, biomaterials and biomedical: TechConnect briefs 2018 (182-185)

© 2018 OOSV. All rights reserved. The use of droplet-based microfluidic systems has increased in the last decade due to the advantages these systems present such as compatibility with many chemical and biological reagents, capability of performing a... Read More about CFD analysis and experimental validation of magnetic droplet generation and deflection across multilaminar flow streams.

Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives (2018)
Journal Article
Thompson, B. R., Rutkevičius, M., Horozov, T. S., Stoyanov, S. D., & Paunov, V. N. (2018). Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives. Materials Chemistry Frontiers, 2(2), 402-409. https://doi.org/10.1039/c7qm00556c

We designed pressure responsive soap–hydrogel bead composites by incorporating agar hydrogel beads of different size distributions within a molten soap matrix at various volume fractions. Upon cooling, the combined suspension of hydrogel beads into t... Read More about Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives.

Correction: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)
Journal Article
Alorabi, A. Q., Tarn, M. D., Gómez-Pastora, J., Bringas, E., Ortiz, I., Paunov, V. N., & Pamme, N. (2017). Correction: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules. Lab on a chip, 17(22), 3934. https://doi.org/10.1039/c7lc90110k

Correction for ‘On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules’ by Ali Q. Alorabi et al., Lab Chip, 2017, DOI: 10.1039/c7lc00918f.

High throughput fabrication of cell spheroids by templating water-in-water Pickering emulsions (2017)
Journal Article
Das, A. A. K., Filby, B. W., Geddes, D. A., Legrande, D., & Paunov, V. N. (2017). High throughput fabrication of cell spheroids by templating water-in-water Pickering emulsions. Materials Horizons, 4(6), 1196-1200. https://doi.org/10.1039/c7mh00677b

© The Royal Society of Chemistry 2017. We report a simple technique for the high throughput generation of tissue spheroids based on the encapsulation of dispersed adherent cells in particle-stabilised water-in-water emulsions. We demonstrate cell enc... Read More about High throughput fabrication of cell spheroids by templating water-in-water Pickering emulsions.

Sound transmission loss of hierarchically porous composites produced by hydrogel templating and viscous trapping techniques (2017)
Journal Article
Thompson, B. R., Taylor, B. L., Qin, Q., Stoyanov, S. D., Horozov, T. S., & Paunov, V. N. (2017). Sound transmission loss of hierarchically porous composites produced by hydrogel templating and viscous trapping techniques. Materials Chemistry Frontiers, 1(12), 2627-2637. https://doi.org/10.1039/c7qm00371d

© 2017 the Partner Organisations. We have developed two different methods for fabrication of hierarchically porous composites which are environmentally friendly, inexpensive and give a large amount of control over the composite microstructure. The hy... Read More about Sound transmission loss of hierarchically porous composites produced by hydrogel templating and viscous trapping techniques.