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Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow (2019)
Journal Article
Algarni, A., Greenman, J., & Madden, L. A. (2019). Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow. Biomicrofluidics, 13(6), https://doi.org/10.1063/1.5123462

Tumor patients are at a high risk of venous thromboembolism (VTE), and the mechanism by which this occurs may involve tumor-derived microvesicles (MVs). Previously, it has been shown that tumor MVs become attached to endothelial cells in static condi... Read More about Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow.

Isolated tumour microparticles induce endothelial microparticle release in vitro (2019)
Journal Article
Faulkner, L. G., Alqarni, S., Maraveyas, A., & Madden, L. A. (2020). Isolated tumour microparticles induce endothelial microparticle release in vitro. Blood Coagulation and Fibrinolysis, 31(1), 35-42. https://doi.org/10.1097/MBC.0000000000000876

© 2019 Wolters Kluwer Health, Inc. All rights reserved. Cancer induces a hypercoagulable state, resulting in an increased risk of venous thromboembolism. One of the mechanisms driving this is tissue factor (TF) production by the tumour, released in s... Read More about Isolated tumour microparticles induce endothelial microparticle release in vitro.

Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme (2019)
Journal Article
Vince, R. V., Kirk, R. J., Aye, M. M., Atkin, S. L., & Madden, L. A. (2020). Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme. Cell Stress and Chaperones, 25(1), 73-80. https://doi.org/10.1007/s12192-019-01048-1

Induction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible hea... Read More about Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.

Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial (2019)
Journal Article
Northgraves, M. J., Arunachalam, L., Madden, L. A., Marshall, P., Hartley, J. E., MacFie, J., & Vince, R. V. (2019). Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-019-05098-0

© 2019, The Author(s). Background and objectives: To investigate the feasibility of delivering a functional exercise-based prehabilitation intervention and its effects on postoperative length of hospital stay, preoperative physical functioning and he... Read More about Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial.

Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model? (2019)
Journal Article
Olubajo, F., Achawal, S., & Greenman, J. (2020). Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model?. Translational Oncology, 13(1), 1-10. https://doi.org/10.1016/j.tranon.2019.09.002

© 2019 The Authors BACKGROUND: One way to overcome the genetic and molecular variations within glioblastoma is to treat each tumour on an individual basis. To facilitate this, we have developed a microfluidic culture paradigm that maintains human gli... Read More about Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model?.

Transcriptomic Adjustments of Staphylococcus aureus COL (MRSA) Forming Biofilms Under Acidic and Alkaline Conditions (2019)
Journal Article
Efthimiou, G., Tsiamis, G., Typas, M., & Pappas, K. (2019). Transcriptomic Adjustments of Staphylococcus aureus COL (MRSA) Forming Biofilms Under Acidic and Alkaline Conditions. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.02393

© Copyright © 2019 Efthimiou, Tsiamis, Typas and Pappas. Methicillin-resistant Staphylococcus aureus (MRSA) strains are important human pathogens and a significant health hazard for hospitals and the food industry. They are resistant to β-lactam anti... Read More about Transcriptomic Adjustments of Staphylococcus aureus COL (MRSA) Forming Biofilms Under Acidic and Alkaline Conditions.

Retrospective Medical Record Research: Reflections of A Unsponsored Researcher (2019)
Journal Article
Bature, F., Guinn, B., Vseteckova, J., Pang, D., & Pappas, Y. (2019). Retrospective Medical Record Research: Reflections of A Unsponsored Researcher. Biomedical Journal of Scientific & Technical Research, 21(4), 16080-16086. https://doi.org/10.26717/BJSTR.2019.21.003642

This article is a reflective narrative by the author following the successful completion of a doctoral thesis involving the analysis of primary care data. The aim of the study was to identify patterns in signs and symptoms preceding a clinical diagno... Read More about Retrospective Medical Record Research: Reflections of A Unsponsored Researcher.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Vince, R. V., Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., …Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm (2019)
Journal Article
Mewis, R. E., & Archibald, S. J. (2019). Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm. Polyhedron, 171, 578-589. https://doi.org/10.1016/j.poly.2019.08.003

Side-bridged cyclam transition metal complexes (M = Ni(II), Cu(II) and Zn(II)) bearing a phenolic ether or phenolate pendent arm have been synthesised. For [NiL1]+ and [CuL1]+, evidence for a phenoxyl radical was obtained (quasi reversible peak at +0... Read More about Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm.

A bioinformatics toolkit: in silico tools and online resources for investigating genetic variation (2019)
Journal Article
Webster, S. J., Aldossary, M. A., & Hampshire, D. J. (2019). A bioinformatics toolkit: in silico tools and online resources for investigating genetic variation. Seminars in Thrombosis and Hemostasis, 45(7), 674-684. https://doi.org/10.1055/s-0039-1692978

With the advent of large-scale next-generation sequencing initiatives, there is an increasing importance to interpret and understand the potential phenotypic influence of identified genetic variation and its significance in the human genome. Bioinfor... Read More about A bioinformatics toolkit: in silico tools and online resources for investigating genetic variation.

Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus (2019)
Journal Article
Young, T., Li, Y., & Efthimiou, G. (2020). Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus. Waste and biomass valorization, 11(8), 3965-3970. https://doi.org/10.1007/s12649-019-00719-5

Clavulanic acid is an important drug, both medically and economically. It is used to combat bacterial resistance to β-lactam antibiotics and is on the World Health Organisation’s List of Essential Medicines in combination with amoxicillin. An olive o... Read More about Olive Pomace Oil can be Used as an Alternative Carbon Source for Clavulanic Acid Production by Streptomyces clavuligerus.

Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm (2019)
Journal Article
Gandhi, R., Cawthorne, C., Craggs, L. J., Wright, J. D., Domarkas, J., He, P., …Bailey, M. A. (2019). Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm. Journal of Nuclear Cardiology, https://doi.org/10.1007/s12350-019-01946-y

© 2019, The Author(s). Background: Abdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation biomarkers are not yet established. We investigated the feasibility of the cel... Read More about Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm.