University of Hull logo

Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states (2019)
Journal Article
Rahimi, K., Ahmadi, A., Hassanzadeh, K., Soleimani, Z., Sathyapalan, T., Mohammadi, A., & Sahebkar, A. (2019). Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states. Autoimmunity Reviews, https://doi.org/10.1016/j.autrev.2019.05.012

CD4+ T helper (Th) cells are a crucial player in host defense but under certain conditions can contribute to the pathogenesis of inflammatory and autoimmune diseases. Beside the Th1/Th2 subset, several additional Th subsets have been identified, each... Read More

Effects of curcumin on ion channels and pumps: A review (2019)
Journal Article
Tabeshpour, J., Banaeeyeh, S., Eisvand, F., Sathyapalan, T., Hashemzaei, M., & Sahebkar, A. (in press). Effects of curcumin on ion channels and pumps: A review. IUBMB Life, https://doi.org/10.1002/iub.2054

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomised controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., …Sathyapalan, T. (in press). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomised controlled study. Clinical Endocrinology, https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More

Harnessing CRISPR/Cas9 technology in cardiovascular disease (2019)
Journal Article
Rezaei, H., Khadempar, S., Farahani, N., Hosseingholi, E. Z., Hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (in press). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, https://doi.org/10.1016/j.tcm.2019.03.005

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compa... Read More

Systematic review and meta-analysis on the effect of soy on thyroid function (2019)
Journal Article
Otun, J., Sahebkar, A., Östlundh, L., Atkin, S. L., & Sathyapalan, T. (2019). Systematic review and meta-analysis on the effect of soy on thyroid function. Scientific reports, 9, doi:10.1038/s41598-019-40647-x

Soy foods have had an important dietary role in Asian countries for centuries, and in recent years they have become increasingly popular in Western countries as a result of their suggested health benefits. Nevertheless, there are some concerns that s... Read More

Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS) (2018)
Journal Article
Deshmukh, H., Papageorgiou, M., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (in press). Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS). Clinical Endocrinology, 90(1), 162-169. doi:10.1111/cen.13879

Objective The aim of this study was to develop a simple phenotypic algorithm that can capture the underlying clinical and hormonal abnormalities to help in the diagnosis and risk stratification of polycystic ovary syndrome (PCOS). Methods The study... Read More

Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome (2018)
Journal Article
Alalami, H., Sathyapalan, T., & Atkin, S. L. (2018). Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, doi:10.1177/2042018818805674

Women with polycystic ovary syndrome (PCOS) have an adverse metabolic profile with an increased risk of prediabetes and type 2 diabetes (T2DM); however, it is unclear if PCOS is associated with increased cardiovascular events in later years independe... Read More

Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women (2018)
Journal Article
Papageorgiou, M., Sathyapalan, T., & Schutte, R. (in press). Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women. Journal of Cachexia, Sarcopenia and Muscle, doi:10.1002/jcsm.12359

© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: Despite several muscle mass measures being used in the current defi... Read More

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., …Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. doi:10.1111/dom.13548

Aims Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., …Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. doi:10.1111/dom.13555

Objective This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes. Research Design A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More

Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review (2018)
Journal Article
Reyes-Muñoz, E., Sathyapalan, T., Rossetti, P., Shah, M., Long, M., Buscema, M., …Vitale, S. G. (2018). Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review. Advances in Therapy, 35(11), 1805-1815. doi:10.1007/s12325-018-0810-1

Polycystic ovary syndrome (PCOS) affects 6–10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin... Read More

Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement? (2009)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement?. Diabetes, Obesity and Metabolism, 12(6), 540-544. doi:10.1111/j.1463-1326.2009.01190.x

Aim: The benefit of direct, as opposed to calculated, low density lipoprotein - cholesterol (LDL-C) measurement remains unclear. This study compared the biological variability of direct LDL in patients with type 2 diabetes (T2DM) on equivalent doses... Read More