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Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist (2019)
Journal Article
Burke, B., Miranda, C., Lee, R., Renard, I., Nigam, S., Clemente, G., …Archibald, S. (2019). Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist. The Journal of nuclear medicine : JNM, jnumed.118.218008. https://doi.org/10.2967/jnumed.118.218008

Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, autoimmune diseases and during stem cell based repair processes after stroke and myocardial infarction. Previously reported po... Read More

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles (2019)
Journal Article
Cain, A. N., Carder Freeman, T. N., Roewe, K. D., Cockriel, D. L., Hasley, T. R., Maples, R. D., …Hubin, T. J. (2019). Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles. Dalton transactions : an international journal of inorganic chemistry / RSoC, 48(8), 2785-2801. https://doi.org/10.1039/c8dt04728f

A number of disease states including WHIM syndrome, HIV infection and cancer have been linked to the chemokine receptor CXCR4. High-affinity CXCR4 antagonist transition metal complexes of configurationally restricted bis-tetraazamacrocyclic ligands h... Read More