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Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study (2018)
Journal Article
Boland, J. W., Allgar, V., Boland, E. G., Kaasa, S., Hjermstad, M. J., & Johnson, M. J. (2019). Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study. Palliative medicine, 33(2), 206-212. https://doi.org/10.1177/0269216318811011

Background: Performance status, a predictor of cancer survival, and ability to maintain independent living deteriorate in advanced disease. Understanding predictors of performance status trajectory could help identify those at risk of functional det... Read More about Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study.

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., …Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey (2018)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., …Cleland, J. G. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey. Clinical Research in Cardiology, 108(5), 510-519. https://doi.org/10.1007/s00392-018-1380-6

© 2018, The Author(s). Background: Heart failure is heterogeneous in aetiology, pathophysiology, and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one rea... Read More about Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey.

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line (2018)
Journal Article
Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), https://doi.org/10.3390/proteomes6040044

Glioblastomas (GBM) are the most common grade 4 brain tumours; patients have very poor prognosis with an average survival of 15 months after diagnosis. Novel research lines have begun to explore aberrant protein arginine methylation (ArgMe) as a poss... Read More about Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line.

Integration of oncology and palliative care: a Lancet Oncology Commission (2018)
Journal Article
Kaasa, S., Loge, J. H., Aapro, M., Albreht, T., Anderson, R., Bruera, E., …Lundeby, T. (2018). Integration of oncology and palliative care: a Lancet Oncology Commission. The lancet oncology, 19(11), e588-e653. https://doi.org/10.1016/s1470-2045%2818%2930415-7

Full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the... Read More about Integration of oncology and palliative care: a Lancet Oncology Commission.

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity (2018)
Journal Article
Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., …Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016...eeradbiomed.2018.10.422

Obesity leading to hyperlipidaemia and atherosclerosis is recognised to induce morphological and metabolic changes in many tissues. However, hyperlipidaemia can occur in the absence of obesity. The impact of the latter scenario on skeletal muscle and... Read More about Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., …Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. https://doi.org/10.1111/dom.13555

Objective This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes. Research Design A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More about Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache (2018)
Journal Article
Buture, A., Ahmed, F., Dikomitis, L., & Boland, J. W. (2018). Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. Neurological Sciences, 40(1), 25–39. doi:10.1007/s10072-018-3598-5

Introduction Patients with cluster headache (CH), the most common trigeminal autonomic cephalalgia, often face delayed diagnosis, misdiagnosis and mismanagement. Objectives To identify, appraise and synthesise clinical studies on the delays in diagn... Read More about Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache.

Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS (2018)
Journal Article
Aye, M. M., Butler, A. E., Kilpatrick, E. S., Kirk, R., Vince, R., Rigby, A. S., …Atkin, S. L. (2018). Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS. Frontiers in endocrinology, 9(OCT), https://doi.org/10.3389/fendo.2018.00592

Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant... Read More about Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS.

Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study (2018)
Journal Article
Pinto, C., Bristowe, K., Witt, J., Davies, J. M., de Wolf-Linder, S., Dawkins, M., …Murtagh, F. E. (2018). Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study. Annals of palliative medicine, 7(s3), S137-S150. https://doi.org/10.21037/apm.2018.09.02

Background: Routine use of outcome measures in palliative care is recommended to demonstrate and improve quality of care. The use of outcome measures is relatively recent in UK specialist palliative care services and understanding their use in practi... Read More about Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study.

Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF (2018)
Journal Article
Shah, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Pan, D., & Clark, A. L. (2019). Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF. Clinical Research in Cardiology, 108(5), 468–476. https://doi.org/10.1007/s00392-018-1376-2

Background Patients with chronic conditions, such as heart failure, swim regularly and most rehabilitation exercises are conducted in warm hydrotherapy pools. However, little is known about the acute effects of warm water immersion (WWI) on cardiac... Read More about Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF.

Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity (2018)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. (2018). Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity. Nutrients, 10(10), https://doi.org/10.3390/nu10101336

The type 2 family of taste receptors (T2Rs) detect and respond to bitter tastants. These receptors are expressed throughout the gastrointestinal (GI) tract, with location dependant roles. In the oral cavity, T2Rs are involved in the conscious percept... Read More about Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity.

Does advance care planning in addition to usual care reduce hospitalisation for patients with advanced heart failure: A systematic review and narrative synthesis (2018)
Journal Article
Kernick, L., Hogg, K., Millerick, Y., Murtagh, F., Djahit, A., & Johnson, M. (2018). Does advance care planning in addition to usual care reduce hospitalisation for patients with advanced heart failure: A systematic review and narrative synthesis. Palliative medicine, 32(10), 1539-1551. https://doi.org/10.1177/0269216318801162

BACKGROUND: People with advanced heart failure have repeated hospital admissions. Advance care planning can support patient preferences, but studies in people with heart failure have not been assessed. AIM: To evaluate the literature regarding advan... Read More about Does advance care planning in addition to usual care reduce hospitalisation for patients with advanced heart failure: A systematic review and narrative synthesis.

What are the patterns of compliance with Early Warning Track and Trigger Tools: A narrative review (2018)
Journal Article
Credland, N., Dyson, J., & Johnson, M. J. (2018). What are the patterns of compliance with Early Warning Track and Trigger Tools: A narrative review. Applied nursing research : ANR, 44, 39-47. https://doi.org/10.1016/j.apnr.2018.09.002

© 2018 Elsevier Inc. Background: Early Warning Scores were introduced into acute hospitals in 2000. 99% of acute hospitals employ a EWS to monitor deteriorating patients with 97.9% of these linked to a referral protocol. Despite this high level of ad... Read More about What are the patterns of compliance with Early Warning Track and Trigger Tools: A narrative review.

The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study (2018)
Journal Article
Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), doi:10.3389/fendo.2018.00531

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on... Read More about The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study.

Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians (2018)
Journal Article
Gopal-Kothandapani, J. S., Evans, L. F., Walsh, J. S., Gossiel, F., Rigby, A. S., Eastell, R., & Bishop, N. J. (2019). Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians. Clinical Endocrinology, 90(1), 222-231. doi:10.1111/cen.13825

Objectives It is well established that UK Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and geneti... Read More about Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians.

Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition (2018)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., …Beckett, E. (2018). Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition. American journal of human biology : the official journal of the Human Biology Council, 30(5), https://doi.org/10.1002/ajhb.23166

Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-t... Read More about Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition.

Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach (2018)
Journal Article
Papageorgiou, M., Wells, L., Williams, C., White, K. L., De Santis, B., Liu, Y., …Sathyapalan, T. (2018). Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach. Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment, 35(10), 2032-2044. doi:10.1080/19440049.2018.1508890

Deoxynivalenol (DON) is a Fusarium toxin, to which humans are frequently exposed via diet. Although the elderly are speculated to be sensitive to the toxic effects of DON as a result of age-related conditions, disease and altered DON metabolism, ther... Read More about Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach.

The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness (2018)
Journal Article
Cuthbert, J. J., Kearsley, J. W., Kazmi, S., Kallvikbakka-Bennett, A., Weston, J., Davis, J., …Clark, A. L. (2019). The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness. Clinical Research in Cardiology, 108(2), 185–193. https://doi.org/10.1007/s00392-018-1342-z

© 2018, The Author(s). Background: Differentiating heart failure from chronic obstructive pulmonary disease (COPD) in a patient presenting with breathlessness is difficult but may have implications for outcome. We investigated the prognostic impact o... Read More about The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness.

Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care (2018)
Journal Article
Allgar, V. L., Chen, H., Richfield, E., Currow, D., Macleod, U., & Johnson, M. J. (2018). Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care. Journal of pain and symptom management, 56(4), 602-612. doi:10.1016/j.jpainsymman.2018.07.002

Background. The assessment of patients' needs for care is a critical step in achieving patient-centered cancer care. Tools can be used to assess needs and inform care planning. The Needs Assessment Tool:Progressive DiseaseeCancer (NAT:PD-C) is an Aus... Read More about Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care.