Skip to main content

Research Repository

Advanced Search

All Outputs (602)

The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation (2024)
Thesis
Greaves, J. (2024). The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4609527

The proper activation and subsequent differentiation of naive CD4+ T cells into effector T helper and regulatory T cells is vital for directing an appropriate adaptive immune response to specific infections. Recent evidence has identified long non-co... Read More about The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation.

Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis (2024)
Thesis
Muscutt, E. W. (2024). Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4557553

Visceral leishmaniasis (VL) causes immune and haematological dysfunction and is fatal in >95% of cases if left untreated. While macrophages are vital for efficient Leishmania parasite clearance, parasite-macrophage interactions are critical for VL pr... Read More about Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis.

PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop (2023)
Presentation / Conference
Hammond, A., Whittaker, J., Frere, T., & Stockbridge, C. (2023, December). PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop. Poster presented at 5th Developing Excellence in Medical Education Conference (DEMEC): Education in the wider context – the patient, the team and the global community, Manchester

Background: Unconscious biases are beliefs, attitudes and stereotypes that can affect our understanding and decisions in a way that we're not aware of. If steps aren't taken to avoid acting on such biases, it can lead to unfair treatments and discri... Read More about PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop.

Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture (2023)
Presentation / Conference
Hammond, A. (2023, November). Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture. Presented at Yorkshire and Humber School of Psychiatry Annual Conference, Harrogate

During this session you will: * Consider what is meant by the term ‘microaggression’ * Reflect on your own ‘culture’ * Consider what might impact your responding to a microaggression in everyday life * Be introduced to the Recognise, Choose, Act... Read More about Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture.

Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses (2023)
Presentation / Conference
Hammond, A., Frere, T., Stockbridge, C., & Whittaker, J. (2023, November). Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses. Paper presented at Simulated Patients in Healthcare Education: A National Conference, Online

Presentation Objectives: To develop awareness of HYMS innovative Microaggression/Bystander Training delivered to our Communication Masterclass tutors & SPs to improve their skills and confidence in providing an opportunity for students to discuss... Read More about Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses.

Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4587991

Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.

Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I (2023)
Thesis
Bolanle, O. I. (2023). Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4420724

Despite the plethora of drugs currently available for managing coronary artery disease (CAD) patients with or without type 2 diabetes mellitus (T2DM), yet CAD frequently progresses, necessitating a coronary artery bypass graft (CABG) procedure using... Read More about Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I.

High-intensity interval training in patients with intermittent claudication (2023)
Journal Article
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., …Chetter, I. C. (2023). High-intensity interval training in patients with intermittent claudication. Journal of vascular surgery, 78(4), 1048-1056.e4. https://doi.org/10.1016/j.jvs.2023.05.045

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

Predicting and preventing relapse of depression in primary care: a mixed methods study (2023)
Thesis
Moriarty, A. S. (2023). Predicting and preventing relapse of depression in primary care: a mixed methods study. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4483741

Background Most people with depression are managed in primary care. Relapse (reemergence of depression symptoms after improvement) is common and contributes to the burden and morbidity associated with depression. There is a lack of evidence-based ap... Read More about Predicting and preventing relapse of depression in primary care: a mixed methods study.

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (2023)
Journal Article
Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. (2023). Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Cancer Research, 83(16_Supplement), B001-B001. https://doi.org/10.1158/1538-7445.kidney23-b001

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive cancer. In the UK, there are around 9000 diagnoses and 3000 deaths annually. Targeted therapies that inhibit angiogenic regulators, such as bevac... Read More about Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Journal Article
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.

Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach (2023)
Presentation / Conference
Lillicrap, M., & Hammond, A. (2023, June). Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach. Presented at Facilitator Development Day - University of Cambridge School of Medicine, Cambridge

Objectives: * To consider the challenges teachers/tutors (experts) might face in helping medical students (novices) develop their clinical reasoning skills * To develop awareness of the role of faculty development in helping teachers/tutors deve... Read More about Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach.

Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective (2023)
Presentation / Conference
Hammond, A., & Ambrose, L. (2023, May). Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective. Presented at 9th International Clinical Skills Conference, Prato, Italy

Objectives 1) To consider current & future impact of remote consulting & the covid pandemic on our cognitive load as clinical reasoning ‘experts’ 2) To consider & reflect on the insights this has provided us as clinicians & educators into the stud... Read More about Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective.

Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations (2023)
Presentation / Conference
Hammond, A., Gay, S., Matthan, J., Cooper, N., & Singh, M. (2023, May). Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations. Presented at 9th International Clinical Skills Conference, Prato, Italy

Workshop Objectives To consider the particular challenges for clinical tutors (experts) in helping medical students (novices) develop their clinical reasoning skills. To develop awareness of innovative approaches to faculty development to help tuto... Read More about Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations.

Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop (2023)
Presentation / Conference
Hammond, A., Whittaker, J., Frere, T., & Stockbridge, C. (2023, May). Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop. Presented at 9th International Clinical Skills Conference, Prato, Italy

Oral Presentation objectives 1) To develop awareness of our innovative workshop delivered to our Simulated Patients to increase their understanding of unconscious biases, how these might impact their work as Simulated Patients in our teaching and as... Read More about Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop.

Bringing fictional characters to life: reflections on co-creating a comic book with members of the public (2023)
Journal Article
Cairns, J. M., Roberts, H., Al-Khafaji, G., & Kwater, M. (2023). Bringing fictional characters to life: reflections on co-creating a comic book with members of the public. Research Involvement and Engagement, 9(1), Article 28. https://doi.org/10.1186/s40900-023-00437-2

There are growing calls for cancer screening to become more personalised by considering a range of risk factors, rather than a one-size-fits-all, age-based approach. The aim of this public involvement was to co-create a comic book about bowel cancer... Read More about Bringing fictional characters to life: reflections on co-creating a comic book with members of the public.

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. (2023). The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory (2023)
Thesis
Wray, A. (2023). Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4609487

Background: In the UK, 46,300 children are bereaved of a parent each year. We understand bereaved people need a supportive response from those around them. However, there is limited evidence to inform our understanding of this. Aim: To explore how c... Read More about Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. (2023). Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.