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Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood (2019)
Journal Article
Das, A. A., Medlock, J., Liang, H., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (in press). Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood. Journal of materials chemistry B, Materials for biology and medicine /, https://doi.org/10.1039/c9tb00679f

We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-ce... Read More

The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice (2019)
Journal Article
Matsakas, A., Elashry, M. I., Eldaey, A., Glenske, K., Wenisch, S., Arnhold, S., & Patel, K. (in press). The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice. Journal of anatomy,

Obesity is a worldwide nutritional disorder affecting body performance including skeletal muscle. Inhibition of myostatin not only increases the muscle mass but also it reduces body fat accumulation. We examined the effect of high-fat diet on the phe... Read More

Lipids and insulin regulate mitochondrial‐derived peptide ( MOTS ‐c) in PCOS and healthy subjects (2019)
Journal Article
Ramanjaneya, M., Jerobin, J., Bettahi, I., Bensila, M., Aye, M., Siveen, K. S., …Atkin, S. L. (2019). Lipids and insulin regulate mitochondrial‐derived peptide ( MOTS ‐c) in PCOS and healthy subjects. Clinical Endocrinology, https://doi.org/10.1111/cen.14007

Objective Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS‐c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and A... Read More

Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo (2019)
Journal Article
Hamdi, M., Sánchez-Calabuig, M. J., Rodríguez-Alonso, B., Bagés-Arnal, S., Roussi, K., Sturmey, R., …Rizos, D. (in press). Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo. Reproduction, https://doi.org/10.1530/REP-18-0561

During its journey through the oviduct, the bovine embryo may induce transcriptomic and metabolic responses, via direct or indirect contact, from bovine oviduct epithelial cells (BOEC). An in vitro model using polyester mesh was established, allowing... Read More

Socioeconomic position and use of health care in the last year of life: a systematic review and meta-analysis (2019)
Journal Article
Davies, J. M., Sleeman, K. E., Leniz, J., Wilson, R., Higginson, I. J., Verne, J., …Murtagh, F. E. (2019). Socioeconomic position and use of health care in the last year of life: a systematic review and meta-analysis. PLoS Medicine, 16(4), https://doi.org/10.1371/journal.pmed.1002782

BACKGROUND: Low socioeconomic position (SEP) is recognized as a risk factor for worse health outcomes. How socioeconomic factors influence end-of-life care, and the magnitude of their effect, is not understood. This review aimed to synthesise and qua... Read More

Battery-operated fan and chronic breathlessness: does it help? (2019)
Journal Article
Barnes-Harris, M., Swan, F., Allgar, V., Booth, S., Currow, D., Hart, S., …Johnson, M. (in press). Battery-operated fan and chronic breathlessness: does it help?. BMJ Supportive & Palliative Care, https://doi.org/10.1136/bmjspcare-2018-001749

Objectives To examine whether use of a hand-held fan (‘fan’) improves breathlessness and increases physical activity. Methods A secondary exploratory analysis using pooled data from the fan arms of two feasibility randomised controlled trials in p... Read More

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports (2019)
Journal Article
Scully, D., & Matsakas, A. (in press). Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports. International journal of sports medicine, https://doi.org/10.1055/a-0884-0734

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as p... Read More

The roles of dispositional coping style and social support in helping people with respiratory disease cope with a breathlessness crisis (2019)
Journal Article
Garcia, M., Luckett, T., Johnson, M., Hutchinson, A., Lal, S., & Phillips, J. (in press). The roles of dispositional coping style and social support in helping people with respiratory disease cope with a breathlessness crisis. Journal of advanced nursing, https://doi.org/10.1111/jan.14039

Aim: To explore the role of coping moderators in self-management of breathlessness crises by people with advanced respiratory disease. Design: A secondary analysis of semi-structured interview data. Methods: Interviews with patients who had a... Read More

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms (2019)
Journal Article
Featherby, S., Xiao, Y. P., Ettelaie, C., Nikitenko, L. L., Greenman, J., & Maraveyas, A. (2019). Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-42738-1

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set... Read More

The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma (2019)
Journal Article
Oguh-Olayinka, L., Agarwal, V., Ranatunge, D., Campbell, A., Laufer, S., Cawkwell, L., & Lind, M. J. (in press). The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma. Pathology and Oncology Research, https://doi.org/10.1007/s12253-019-00652-x

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclo-oxygena... Read More

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. (2019)
Journal Article
Kirk, R., Madden, L., Peart, D., Aye, M., Atkin, S., & Vince, R. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10, https://doi.org/10.3389/fendo.2019.00200

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell deri... Read More

Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in Diabetes Mellitus (2019)
Journal Article
Paseban, M., Mohebbati, R., Niazmand, S., Sathyapalan, T., & Sahebkar, A. (2019). Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in Diabetes Mellitus. Biomolecules, 9(4), 118. https://doi.org/10.3390/biom9040118

Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats.... Read More

Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema (2019)
Journal Article
Shoaib, A., Mamas, M. A., Ahmad, Q. S., McDonagh, T. M., Hardman, S. M., Rashid, M., …Cleland, J. G. F. (in press). Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema. International journal of cardiology, doi:10.1016/j.ijcard.2019.03.020

Background Most trials of patients hospitalized for heart failure focus on breathlessness (alveolar pulmonary oedema) but worsening peripheral oedema is also an important presentation. We investigated the relationship between the severity of periphe... Read More

Rural-urban disparities in total physical activity, body composition, and related health indicators: An Atlantic PATH study (2019)
Journal Article
Forbes, C., Yu, Z. M., Cui, Y., DeClercq, V., Grandy, S., Parker, L., …Keats, M. (in press). Rural-urban disparities in total physical activity, body composition, and related health indicators: An Atlantic PATH study. Journal of Rural Health, https://doi.org/10.1111/jrh.12363

Purpose To describe and compare the sociodemographic and lifestyle characteristics of urban and rural residents in Atlantic Canada. Methods Cross‐sectional analyses of baseline data from the Atlantic Partnership for Tomorrow's Health cohort were... Read More

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomised controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., …Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomised controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More

Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from SICA-HF (2019)
Journal Article
Nuzzi, V., Pellicori, P., Nikolaidou, T., Kallvikbacka-Bennett, A., Torromeo, C., Barilla, F., …Clark, A. (in press). Clinical and prognostic association of total atrial and conduction time in patients with heart failure: a report from SICA-HF. European journal of heart failure,

Background: The total atrial conduction time can be measured as the time from the onset of the P wave on the ECG to the peak of the A wave recorded at the mitral annulus using tissue Doppler imaging (A´; P-A´TDI); when prolonged, it might predict inc... Read More

How can training in care of the dying be improved? (2019)
Journal Article
Gajebasia, S., Pearce, J., Redman, M., Johnson, M., & Finn, G. (in press). How can training in care of the dying be improved?. Clinical Teacher, doi:10.1111/tct.12999

Care of the dying patient is an intrinsic part of the role of fFoundation yYear fDoctors (FYs). This study aimed to explore FYs’ experiences of training and their perceived training needs for their role in care of the dying.

Alterations in platelet alpha granule secretion and adhesion on collagen under flow in mice lacking the atypical Rho GTPase RhoBTB3 (2019)
Journal Article
Berger, M., Riley, D. R. J., Lutz, J., Khalil, J. S., Aburima, A., Naseem, K. M., & Rivero, F. (2019). Alterations in platelet alpha granule secretion and adhesion on collagen under flow in mice lacking the atypical Rho GTPase RhoBTB3. Cells, 8(2), 149. doi:10.3390/cells8020149

Typical Rho GTPases, like Rac1, Cdc42 and RhoA, act as molecular switches regulating various aspects of platelet cytoskeleton reorganization. The loss of these enzymes results in reduced platelet functionality. Atypical Rho GTPases of the RhoBTB su... Read More

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More