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Myocardial fibrosis in stroke survivors (2015)
Journal Article
Wong, K., Sze, S., Wong, S., McSwiggan, S., Allgar, V., MacWalter, R., & Struthers, A. D. (2015). Myocardial fibrosis in stroke survivors. International journal of cardiology, 187(1), 138-140. https://doi.org/10.1016/j.ijcard.2015.03.212

Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac dea... Read More about Myocardial fibrosis in stroke survivors.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., …Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

What stops students working well in clinical environments? (2015)
Presentation / Conference
Hammond, A., & Henderson, J. (2015, March). What stops students working well in clinical environments?. Paper presented at UK Council for Clinical Communication National Conference, Manchester

Aims * To discuss the challenges for Undergraduate Medical Students when moving from University Based to Full time clinical placements * Discuss HYMS’ Year Three Induction Block * To share ideas regarding how to address these challenges

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade (2015)
Journal Article
Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., …Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. https://doi.org/10.1182/blood-2014-05-574491

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism fo... Read More about Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade.

QT peak prolongation predicts cardiac death following stroke (2015)
Journal Article
Wong, K. Y. K., MacWalter, R. S., Wong, S. Y. S., Suich, J., Douglas, D., Fraser, H. W., …Struthers, A. D. (2015). QT peak prolongation predicts cardiac death following stroke. Journal of cardiology and current research, 2(1), Article 00050. https://doi.org/10.15406/jccr.2015.02.00050

Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak. We found QT peak (QTp)... Read More about QT peak prolongation predicts cardiac death following stroke.

Prescribing patterns to optimize heart rate (2015)
Journal Article
Dierckx, R., Cleland, J. G., Parsons, S., Putzu, P., Pellicori, P., Dicken, B., …Clark, A. L. (2015). Prescribing patterns to optimize heart rate. JACC: Heart Failure, 3(3), 224-230. https://doi.org/10.1016/j.jchf.2014.11.003

Objectives This study sought to characterize patients attending a community heart failure (HF) clinic and identified those who were eligible for optimization of beta-blockers (BB) or ivabradine. Background Among patients with HF due to left vent... Read More about Prescribing patterns to optimize heart rate.

Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence (2015)
Journal Article
Lucock, M., Yates, Z., Martin, C., Choi, J., Beckett, E., Boyd, L., …Veysey, M. (2015). Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. Bba Clinical, 3, 107-112. https://doi.org/10.1016/j.bbacli.2014.11.005

Purpose The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homoc... Read More about Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.

Meridians Under the Skin (2014)
Journal Article
Shaw, V., & Aland, R. C. (2014). Meridians Under the Skin. European Journal of Oriental Medicine, 7(6),

The physical nature of the acupuncture meridian system is currently the subject of enquiry. The original structural descriptions for the meridian system contained in the Huang Di Nei Jing, The Yellow Emperor's Canon of Internal Medicine, are detailed... Read More about Meridians Under the Skin.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.

The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members) (2014)
Presentation / Conference
Shaw, V. (2014, December). The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members). Poster presented at Joint Meeting of the Anatomical Society and the Primate Society of Great Britain: Primate Ecomorpholgy, University of Birmingham, Birmingham, UK

Anatomical drawings have formed the cornerstone of anatomical education in the West for centuries before the arrival of photography, the internet and virtual resources. The images in Vesalius’ On the Fabric of the Human Body and later in Gray’s Anato... Read More about The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members).

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling (2014)
Journal Article
Daskoulidou, N., Xu, S. Z., Zeng, B., Gomez, M. F., Berglund, L. M., Atkin, S. L., …Daskoulidou, N. (2015). High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling. Journal of Molecular Medicine, 93(5), 511-521. https://doi.org/10.1007/s00109-014-1234-2

© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx.... Read More about High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.

Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor (2014)
Journal Article
Crooks, M. G., Fahim, A., Naseem, K. M., Morice, A. H., & Hart, S. P. (2014). Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. PLoS ONE, 9(10), Article ARTN e111347. https://doi.org/10.1371/journal.pone.0111347

Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood. Activated platelets can release pro-fibrotic mediators th... Read More about Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor.

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis (2014)
Journal Article
Kotecha, D., Holmes, J., Krum, H., Altman, D. G., Manzano, L., Cleland, J. G., …Flather, M. D. (2014). Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis. Lancet, 384(9961), 2235-2243. https://doi.org/10.1016/S0140-6736%2814%2961373-8

Background: Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of... Read More about Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis.

A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency (2014)
Journal Article
Carradice, D., Wallace, T., Gohil, R., & Chetter, I. (2014). A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency. Annals of Surgery, 260(2), 396-401. https://doi.org/10.1097/sla.0000000000000541

Objective: To test the hypothesis that patients with soft tissue changes related to superficial venous insufficiency (SVI) have greater benefits from treatment than those with only symptomatic varicose veins. Background: A commonly held view is that... Read More about A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency.

Linking Early Clinical Experience and Basic Science using Images of Disease (2014)
Presentation / Conference
Cookson, J., Hammond, A., Ken, W., & Owen, S. (2014, August). Linking Early Clinical Experience and Basic Science using Images of Disease. Presented at The International Association for Health Professions Education. AMEE 2014: Excellence in Education - the 21st Century Teacher, Milan, Italy

Short Communication 7C1 (Curriculum: Educational Strategies)

Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients (2014)
Journal Article
Drennan, S., Stafford, N. D., Greenman, J., & Green, V. L. (2014). Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients. Journal of clinical & cellular immunology, 5(4), Article 241. https://doi.org/10.4172/2155-9899.1000241

Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response. However, their immunosu... Read More about Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients.

Hyperpolarisation through reversible interactions with parahydrogen (2014)
Journal Article
Lloyd, L. S., Asghar, A., Burns, M. J., Charlton, A., Coombes, S., Cowley, M. J., …Ruddlesden, A. J. (2014). Hyperpolarisation through reversible interactions with parahydrogen. Catalysis science & technology, 4(10), 3544-3554. https://doi.org/10.1039/c4cy00464g

We describe here how the complexes Ir(COD)(NHC)Cl [NHC = IMes, SIMes, IPr, SIPr, ICy, IMe and ImMe2NPri2] provide significant insight into the catalytic process that underpins the hyperpolarization method signal amplification by reversible exchange (... Read More about Hyperpolarisation through reversible interactions with parahydrogen.

A previously undescribed dorsal branch of the anterior interosseous nerve (2014)
Presentation / Conference
Shaw, V., & Morris, J. (2014, July). A previously undescribed dorsal branch of the anterior interosseous nerve. Poster presented at Anatomical Society Summer Meeting: Skin and Bones, Bradford, UK

The path of the anterior interosseous nerve is commonly described as passing along the deep compartment of the volar aspect of the forearm where it innervates the muscles in that compartment including pronator quadratus. Previous electromyographi... Read More about A previously undescribed dorsal branch of the anterior interosseous nerve.