All Outputs (602)

Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker (2014)
Journal Article
Garimella, V., Hussain, T., Agarwal, V., Radhakrishna, S., Fox, J. N., Kneeshaw, P. J., …Cawkwell, L. (2014). Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker. International journal of surgery, 12(8), 821-826. https://doi.org/10.1016/j.ijsu.2014.06.009

Primary tamoxifen therapy has been widely used to treat elderly women with ER-positive breast cancer in the past. Aromatase inhibitors may be more beneficial than tamoxifen when used as primary endocrine therapy in elderly patients. We aimed to retro... Read More about Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker.

A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers (2014)
Journal Article
Faruqi, S., Wright, C., Thompson, R., & Morice, A. H. (2014). A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. British Journal of Clinical Pharmacology, 78(6), 1272-1280. https://doi.org/10.1111/bcp.12458

AIMS The examination of cough reflex sensitivity through inhalational challenge can be utilized to demonstrate pharmacological end points. Here we compare the effect of butamirate, dextromethorphan and placebo on capsaicin-induced cough in healthy vo... Read More about A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers.

Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain (2014)
Journal Article
Lutz, J., Grimm-Günter, E. M. S., Joshi, P., & Rivero, F. (2014). Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Histochemistry and cell biology, 142(5), 511-528. https://doi.org/10.1007/s00418-014-1235-9

RhoBTB3 is an atypical member of the Rho family of small GTPases. It localizes at the Golgi apparatus and endosomes and is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. Previous studies using Northern bl... Read More about Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.

Chōng meridian an ancient Chinese description of the vascular system? (2014)
Journal Article
Shaw, V. (2014). Chōng meridian an ancient Chinese description of the vascular system?. Acupuncture in Medicine, 32(3), 279-285. https://doi.org/10.1136/acupmed-2013-010496

The objectives of this research are, first, to establish if the extraordinary acupuncture meridian known as Chōng, Penetrating Vessel or Sea of Blood, is in essence a description of certain macroscopic parts of the underlying vascular system and, sec... Read More about Chōng meridian an ancient Chinese description of the vascular system?.

On the definition of chronic cough and current treatment pathways: An international qualitative study (2014)
Journal Article
Faruqi, S., Murdoch, R. D., Allum, F., & Morice, A. H. (2014). On the definition of chronic cough and current treatment pathways: An international qualitative study. Cough, 10(1), Article 5. https://doi.org/10.1186/1745-9974-10-5

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.Methods:... Read More about On the definition of chronic cough and current treatment pathways: An international qualitative study.

Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame (2014)
Journal Article
Menakaya, C., Rigby, A., Hadland, Y., Barron, E., & Sharma, H. (2014). Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame. Annals of the Royal College of Surgeons of England, 96(2), 106-110. https://doi.org/10.1308/003588414x13824511650335

Introduction: The optimal treatment of high energy tibial fractures remains controversial and a challenging orthopaedic problem. The role of external fi xators for all these tibial fractures has been shown to be crucial. Methods: A fi ve-year consecu... Read More about Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame.

Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials (2014)
Journal Article
Barnes, R., Shahin, Y., Gohil, R., & Chetter, I. (2014). Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials. European Journal of Clinical Investigation, 44(4), 429-440. https://doi.org/10.1111/eci.12244

Background We conducted a systematic review to investigate the effect of electrical stimulation on ulcer healing compared to usual treatment and/or sham stimulation. This systematic review also aimed to investigate the effect of different types of... Read More about Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials.

The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels: 4-Chloro-3-ethylphenol inhibits ORAI channels (2014)
Journal Article
Zeng, B., Chen, G., Daskoulidou, N., & Xu, S. (2014). The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels: 4-Chloro-3-ethylphenol inhibits ORAI channels. British Journal of Pharmacology, 171(5), 1250-1259. https://doi.org/10.1111/bph.12528

Background Depletion of the Ca2+ store by ryanodine receptor (RyR) agonists induces store‐operated Ca2+ entry (SOCE). 4‐Chloro‐3‐ethylphenol (4‐CEP) and 4‐chloro‐m‐cresol (4‐CmC) are RyR agonists commonly used as research tools and diagnostic reagen... Read More about The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels: 4-Chloro-3-ethylphenol inhibits ORAI channels.

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure (2014)
Journal Article
Ingle, L., Rigby, A. S., Sloan, R., Carroll, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2014). Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart, 100(10), 781-786. https://doi.org/10.1136/heartjnl-2013-304614

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive pow... Read More about Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation (2013)
Journal Article
Souroullas, P., Barnes, R., Lane, R. A., & Chetter, I. (2014). The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation. Annals of vascular surgery, 28(5), 1166-1171. https://doi.org/10.1016/j.avsg.2013.10.017

IntroductionMorbidity and mortality after lower limb amputation (LLA) remain disappointingly high. This study aimed to assess the impact of previous ipsilateral vascular intervention on outcomes after major LLA.MethodsProspective data were collected... Read More about The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation.

Chong Acupuncture Meridian, An Ancient Chinese Description of the Vascular System? (2013)
Presentation / Conference
Shaw, V. (2013, December). Chong Acupuncture Meridian, An Ancient Chinese Description of the Vascular System?. Presented at Anatomical Society Winter Meeting 2013: Assessment Within Medical Education & Sense Organs, Newcastle upon Tyne, UK

The positioning of the acupuncture points in acupuncture is based upon a particular anatomical map known as the jıng luo經絡(meridian network system) which has no obvious correlate in modern anatomy. The generally accepted scholarly opinion is that t... Read More about Chong Acupuncture Meridian, An Ancient Chinese Description of the Vascular System?.

Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease (2013)
Journal Article
Kahal, H., Abouda, G., Rigby, A. S., Coady, A. M., Kilpatrick, E. S., & Atkin, S. L. (2014). Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease. Clinical Endocrinology, 81(4), 523-528. https://doi.org/10.1111/cen.12369

© 2013 John Wiley & Sons Ltd. Introduction: Nonalcoholic fatty liver disease (NAFLD) has been linked to polycystic ovary syndrome (PCOS) and carries an increased risk of liver cirrhosis. Procollagen type 3 amino-terminal peptide (PIIINP) is an inde... Read More about Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease.

Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Gohil, R., Souroullas, P., Khan, J., …Chetter, I. C. (2014). Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair. Annals of vascular surgery, 28(1), 74-79. https://doi.org/10.1016/j.avsg.2013.09.001

Background Aerobic fitness is an important predictor of postoperative outcome in major surgery. In this study, we assess the effects of a period of preoperative exercise on aerobic fitness as measured by cardiopulmonary exercise testing (CPET) in pa... Read More about Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair.

Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. (2013)
Journal Article
Vanicek, N., King, S. A., Gohil, R., Chetter, I. C., & Coughlin, P. A. (2013). Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. Journal of Visualized Experiments, Article e51077. https://doi.org/10.3791/51077

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic conditions. As part of a diagnostic assessment, the early detection of postural deficits is importan... Read More about Computerized dynamic posturography for postural control assessment in patients with intermittent claudication..

Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication (2013)
Journal Article
Shahin, Y., Barnes, R., Barakat, H., & Chetter, I. C. (2013). Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication. Atherosclerosis, 231(2), 283-290. https://doi.org/10.1016/j.atherosclerosis.2013.09.037

Objective The aim of this meta-analysis was to investigate the effect of angiotensin converting enzyme (ACE) inhibitors on maximum walking distance (MWD), pain-free walking distance (PFWD) and ankle brachial pressure index (ABPI) in patients with in... Read More about Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication.

Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Sedman, P., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls. Obesity Surgery, 24(3), 349-358. https://doi.org/10.1007/s11695-013-1100-2

Background Insulin resistance (IR) after bariatric surgery is significantly lower than controls matched for bodymass index (BMI) and is indistinguishable from lean subjects however it is not known if this is the same for associated cardiovascular ris... Read More about Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls.

Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Chetter, I., & McCollum, P. (2014). Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience. Annals of vascular surgery, 28(1), 80-86. https://doi.org/10.1016/j.avsg.2013.07.006

Background The purpose of this study was to evaluate morbidity, mortality, and survival in octogenarians undergoing open repair of ruptured abdominal aortic aneurysms (RAAAs) in comparison to younger patients.MethodsThis investigation was a retrospe... Read More about Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience.

Neural responses to facial expressions support the role of the amygdala in processing threat (2013)
Journal Article
Mattavelli, G., Sormaz, M., Flack, T., Asghar, A. U., Fan, S., Frey, J., …Andrews, T. J. (2014). Neural responses to facial expressions support the role of the amygdala in processing threat. Social Cognitive and Affective Neuroscience, 9(11), 1684-1689. https://doi.org/10.1093/scan/nst162

© The Author (2013). Published by Oxford University Press. The amygdala is known to play an important role in the response to facial expressions that convey fear. However, it remains unclear whether the amygdala's response to fear reflects its role i... Read More about Neural responses to facial expressions support the role of the amygdala in processing threat.

Workshop - Developing Clinical Reasoning Skills in Modern Undergraduate Medical Curricula (2013)
Presentation / Conference
Hammond, A., & Henderson, J. (2013, September). Workshop - Developing Clinical Reasoning Skills in Modern Undergraduate Medical Curricula. Presented at 8th HYMS Education Conference, Bishop Burton, East Yorkshire

Objectives: Following the workshop participants will be able to * Recognise opportunities to strengthen the teaching of clinical reasoning within their environment * Evaluate students’ individual clinical reasoning learning needs * Discuss curre... Read More about Workshop - Developing Clinical Reasoning Skills in Modern Undergraduate Medical Curricula.