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Does the physical examination still have a role in patients with suspected heart failure? (2011)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Zhang, J., Goode, K., Buga, L., Hobkirk, J., …Clark, A. L. (2011). Does the physical examination still have a role in patients with suspected heart failure?. European journal of heart failure, 13(12), 1340-1348. https://doi.org/10.1093/eurjhf/hfr128

AIMS: The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in pati... Read More about Does the physical examination still have a role in patients with suspected heart failure?.

Student‐led research training within the PhD: “PhD experience” conferences (2011)
Journal Article
Mercer, T., Kythreotis, A., Lambert, C., & Hughes, G. (2011). Student‐led research training within the PhD: “PhD experience” conferences. International journal for researcher development, 2(2), 152-166. doi:10.1108/17597511111212736

Purpose – The purpose of this paper is to highlight the significance of student‐led initiatives in PhD development. Design/methodology/approach – A case study is presented utilizing Kolb's model of learning from experience to identify with stude... Read More about Student‐led research training within the PhD: “PhD experience” conferences.

A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs (2011)
Journal Article
Hattersley, S. M., Sylvester, D. C., Dyer, C. E., Stafford, N. D., Haswell, S. J., & Greenman, J. (2012). A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs. Annals of biomedical engineering, 40(6), 1277-1288. doi:10.1007/s10439-011-0428-9

Tumors are heterogeneous masses of cells characterized pathologically by their size and spread. Their chaotic biology makes treatment of malignancies hard to generalize. We present a robust and reproducible glass microfluidic system, for the maintena... Read More about A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs.

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More about Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. doi:10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Preventing unintentional injuries to children under 15 years in the outdoors: A systematic review of the effectiveness of educational programs (2011)
Journal Article
Pearson, M., Hunt, H., Garside, R., Moxham, T., Peters, J., & Anderson, R. (2012). Preventing unintentional injuries to children under 15 years in the outdoors: A systematic review of the effectiveness of educational programs. Injury Prevention, 18(2), 113-123. doi:10.1136/injuryprev-2011-040043

Introduction Unintentional injuries to children in the outdoors have a significant impact on child mortality, development and healthcare costs. This paper presents the findings of a systematic review about the effectiveness of programs that provided... Read More about Preventing unintentional injuries to children under 15 years in the outdoors: A systematic review of the effectiveness of educational programs.

Outcome reporting bias in evaluations of public health interventions: Evidence of impact and the potential role of a study register (2011)
Journal Article
Pearson, M., & Peters, J. (2012). Outcome reporting bias in evaluations of public health interventions: Evidence of impact and the potential role of a study register. Journal of Epidemiology and Community Health, 66(4), 286-289. doi:10.1136/jech.2010.122465

Background: Systematic reviews of the effectiveness of interventions are increasingly used to inform recommendations for public health policy and practice, but outcome reporting bias is rarely assessed. Methods: Studies excluded at full-text stage sc... Read More about Outcome reporting bias in evaluations of public health interventions: Evidence of impact and the potential role of a study register.

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery : BJS, 98(8), 1117-1123. https://doi.org/10.1002/bjs.7615

Background:This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.Methods:Some 280 patients were randomized equally using sealed opaque envelope... Read More about Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure (2011)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2011). Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure. European journal of heart failure, 13(5), 537-542. https://doi.org/10.1093/eurjhf/hfq238

Aims We studied the prognostic significance of the ventilatory equivalent of carbon dioxide production (VEqCO 2 ) at different time-points of a maximal cardiopulmonary exercise test (CPET) in patients with suspected heart failure (HF). Methods and re... Read More about Prognostic significance of different measures of the ventilation-carbon dioxide relation in patients with suspected heart failure.

The Mechanical Significance of the Temporal Fasciae in Macaca fascicularis: An Investigation Using Finite Element Analysis (2011)
Journal Article
Curtis, N., Witzel, U., Fitton, L., O'Higgins, P., & Fagan, M. (2011). The Mechanical Significance of the Temporal Fasciae in Macaca fascicularis: An Investigation Using Finite Element Analysis. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(7), 1178-1190. https://doi.org/10.1002/ar.21415

Computational finite element analyses (FEAs) of the skull predict structural deformations under user specified loads and constraints, with results normally presented as stress and strain distributions over the skull's surface. The applied loads are g... Read More about The Mechanical Significance of the Temporal Fasciae in Macaca fascicularis: An Investigation Using Finite Element Analysis.

N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin (2011)
Journal Article
Xiao, Y. P., Morice, A. H., Compton, S. J., & Sadofsky, L. (2011). N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry, 286(26), (22991-23002). doi:10.1074/jbc.M110.204271. ISSN 0021-9258

Proteinase-activated receptor 1 (PAR1) induces activation of platelet and vascular cells after proteolytic cleavage of its extracellular N terminus by thrombin. In pathological situations, other proteinases may be generated in the circulation and mig... Read More about N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. doi:10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 (2011)
Journal Article
Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., …Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. doi:10.1182/blood-2010-10-312199

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not cl... Read More about Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.

Microsystems for personalized biomolecular diagnostics (2011)
Journal Article
Shaw, K. J., Birch, C., Hughes, E. M., Jakes, A. D., Greenman, J., & Haswell, S. J. (2011). Microsystems for personalized biomolecular diagnostics. Engineering in Life Sciences, 11(2), 121-132. doi:10.1002/elsc.201000175

The development of microfluidic methodology that can be used in conjunction with drug screening and biomolecular diagnostics offers a route to evidence-based personalized medical care. Ideally, all personal diagnostics are best carried out in a rapid... Read More about Microsystems for personalized biomolecular diagnostics.

A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer (2011)
Journal Article
ELFadl, D., Hodgkinson, V. C., Long, E. D., Scaife, L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. The Breast : official journal of the European Society of Mastology, 20(4), 334-337. doi:10.1016/j.breast.2011.02.017

Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of... Read More about A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer.

Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes (2011)
Journal Article
Cheng, F., Hope, C. N., Archibald, S. J., Bradley, J. S., Clark, S., Francesconi, M. G., …Lefebvre, F. (2011). Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes. International Journal of Applied Ceramic Technology, 8(2), 467-481. https://doi.org/10.1111/j.1744-7402.2009.02452.x

The preparation and molecular structures of two novel dimeric transition metal silylamide complexes {Li0.5Zr[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ -NSi(NMe2)3]}2 and {Li0.5Hf[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ-NSi(NMe2)3]}2 with a tetrahedral coordina... Read More about Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes.

Generalizing applied qualitative research on harm reduction: the example of a public injecting typology (2011)
Journal Article
Pearson, M., Parkin, S., & Coomber, R. (2011). Generalizing applied qualitative research on harm reduction: the example of a public injecting typology. Contemporary Drug Problems, 38(1), 61-91. doi:10.1177/009145091103800104

The small sample sizes and context-bound findings of qualitative research are commonly viewed as significant factors that limit its use (or “transferability”) in settings other than those in which the research was originally conducted. This perceived... Read More about Generalizing applied qualitative research on harm reduction: the example of a public injecting typology.

Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis (2011)
Journal Article
Hodgkinson, V. C., ELFadl, D., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis. Journal of Proteomics, 74(5), (698-703). doi:10.1016/j.jprot.2011.02.014. ISSN 1874-3919

Antibody microarrays are powerful new tools in the field of comparative proteomics. The success of the biomarker discovery pipeline relies on the quality of data generated in the discovery phase and careful selection of proteins for the verification... Read More about Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis.

The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics (2011)
Journal Article
Gröning, F., Fagan, M. J., & O'Higgins, P. (2011). The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics. Journal of biomechanics, 44(7), 1304-1312. https://doi.org/10.1016/j.jbiomech.2011.01.008

It is generally accepted that the periodontal ligament (PDL) plays a crucial role in transferring occlusal forces from the teeth to the alveolar bone. Studies using finite element analysis (FEA) have helped to better understand this role and show tha... Read More about The effects of the periodontal ligament on mandibular stiffness: a study combining finite element analysis and geometric morphometrics.