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Establishing key criteria to define and compare models of specialist palliative care: a mixed-methods study using qualitative interviews and Delphi survey (2019)
Journal Article
Firth, A. M., O’Brien, S. M., Guo, P., Seymour, J., Richardson, H., Bridges, C., …Murtagh, F. E. (2019). Establishing key criteria to define and compare models of specialist palliative care: a mixed-methods study using qualitative interviews and Delphi survey. Palliative medicine, https://doi.org/10.1177/0269216319858237

Background: Specialist palliative care services have various configurations of staff, processes and interventions, which determine how care is delivered. Currently, there is no consistent way to define and distinguish these different models of care.... Read More

Health-related quality of life and well-being in people over 75 years of age with end-stage kidney disease managed with dialysis or comprehensive conservative care: A cross-sectional study in the UK and Australia (2019)
Journal Article
Shah, K. K., Murtagh, F. E., McGeechan, K., Crail, S., Burns, A., Tran, A. D., & Morton, R. L. (2019). Health-related quality of life and well-being in people over 75 years of age with end-stage kidney disease managed with dialysis or comprehensive conservative care: A cross-sectional study in the UK and Australia. BMJ open, 9(5), https://doi.org/10.1136/bmjopen-2018-027776

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objective To measure health-related quality of life (HRQoL) and well-being in older people with end-stage ki... Read More

Patient and public involvement in health research in low and middle-income countries: a systematic review (2019)
Journal Article
Cook, N., Siddiqi, N., Twiddy, M., & Kenyon, R. (2019). Patient and public involvement in health research in low and middle-income countries: a systematic review. BMJ open, 9(5), e026514. https://doi.org/10.1136/bmjopen-2018-026514

Objectives: Patient and public involvement (PPI) is argued to lead to higher quality health research, which is more relatable to and helps empower the public. We synthesised the evidence to look for examples of PPI in health research in low/middle-in... Read More

Increasing access to integrated ESKD care as part of Universal Health Coverage (2019)
Journal Article
Yao, Q., Walker, R., Walker, R. C., Vachharajani, T., Tungsanga, K., Trask, M., …Murtagh, F. (2019). Increasing access to integrated ESKD care as part of Universal Health Coverage. Kidney International, 95(4), S1-S33. https://doi.org/10.1016/j.kint.2018.12.005

The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 9... Read More

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2019)
Journal Article
Feigin, V. L., Nichols, E., Alam, T., Bannick, M. S., Beghi, E., Blake, N., …Vos, T. (2019). Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology, 18(5), 459-480. https://doi.org/10.1016/S1474-4422%2818%2930499-X

Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehe... Read More

Airflow relieves chronic breathlessness in people with advanced disease: an exploratory systematic review and meta-analyses (2019)
Journal Article
Swan, F., Newey, A., Bland, M., Allgar, V., Booth, S., Bausewein, C., …Johnson, M. (2019). Airflow relieves chronic breathlessness in people with advanced disease: an exploratory systematic review and meta-analyses. Palliative medicine, 33(6), 618-633. https://doi.org/10.1177/0269216319835393

Background: Chronic breathlessness is a neglected symptom of advanced diseases. Aim: To examine the effect of airflow for chronic breathlessness relief. Design: Exploratory systematic review and meta-analysis. Data sources: Medline, CINA... Read More

Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study (2019)
Journal Article
Ekström, M., Williams, M., Johnson, M. J., Huang, C., & Currow, D. C. (2019). Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study. Journal of pain and symptom management, 57(4), 715-723.e5. https://doi.org/10.1016/j.jpainsymman.2019.01.001

Context Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective We aimed to evaluate agreement between breathlessness severity... Read More

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis (2018)
Journal Article
Forester, N. D., Lowes, S., Mitchell, E., & Twiddy, M. (2019). High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis. European journal of surgical oncology, 45(4), 519-527. https://doi.org/10.1016/j.ejso.2018.12.008

© 2018 Introduction: Provide evidence to support evolving management strategies for high-risk (B3) breast lesions by assessing risk of carcinoma in subgroups of B3 lesions using systematic review and meta-analysis. Methods: Databases identified obser... Read More

TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial (2018)
Journal Article
Edginton, E., Walwyn, R., Twiddy, M., Wright-Hughes, A., Tubeuf, S., Reed, S., …Cottrell, D. (2018). TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial. Journal of Child and Adolescent Mental Health, 30(3), 167-182. doi:10.2989/17280583.2018.1532433

Background: Parenting programmes are recommended for conduct disorders in 5–11 year olds, but ineffective for 25–33%. A feasibility trial was needed to determine whether a confirmatory trial of second-line, manualised short-term psychoanalytic child... Read More

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., …Murray, C. J. L. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1859-1922. https://doi.org/10.1016/S0140-6736%2818%2932335-3

Background How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services.... Read More

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., …Murray, C. J. L. (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1736-1788. https://doi.org/10.1016/S0140-6736%2818%2932203-7

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, nation... Read More

Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
Murray, C. J. L., Callender, C. S. K. H., Kulikoff, X. R., Srinivasan, V., Abate, D., Abate, K. H., …Lim, S. S. (2018). Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1995-2051. https://doi.org/10.1016/S0140-6736%2818%2932278-5

© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international in... Read More

Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (2019). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 30(4), 530-534. https://doi.org/10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More

Building programme theory to develop more adaptable and scalable complex interventions: Realist formative process evaluation prior to full trial (2018)
Journal Article
Brand, S. L., Quinn, C., Pearson, M., Lennox, C., Owens, C., Kirkpatrick, T., …Byng, R. (2019). Building programme theory to develop more adaptable and scalable complex interventions: Realist formative process evaluation prior to full trial. Evaluation, 25(2), 149-170. https://doi.org/10.1177/1356389018802134

Medical Research Council guidelines recognise the need to optimise complex interventions prior to full trial through greater understanding of underlying theory and formative process evaluation, yet there are few examples. A realist approach to format... Read More

Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database (2018)
Journal Article
Nwaru, B. I., Simpson, C. R., Soyiri, I. N., Pillinger, R., Appiagyei, F., Ryan, D., …Sheikh, A. (2018). Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database. BMJ open, 8(6), https://doi.org/10.1136/bmjopen-2017-020075

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Female sex steroid hormones have been implicated in sex-related differences in the development... Read More

Prescribing non-opioid drugs in end-stage kidney disease (2017)
Journal Article
Wilcock, A., Charlesworth, S., Twycross, R., Waddington, A., Worthington, O., Murtagh, F. E., …Kotlinska-Lemieszek, A. (2017). Prescribing non-opioid drugs in end-stage kidney disease. Journal of pain and symptom management, 54(5), 776-787. https://doi.org/10.1016/j.jpainsymman.2017.08.014

Palliative care services are increasingly involved in the care of patients with chronic kidney disease, either alone or as a comorbid condition. Because renal impairment often changes the pharmacokinetic and/or pharmacodynamic effects of a drug, this... Read More

Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting (2017)
Journal Article
Digges, M., Hussein, A., Wilcock, A., Crawford, G. B., Boland, J. W., Agar, M. R., …Johnson, M. J. (2018). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting. Journal of palliative medicine, 21(1), 37-43. https://doi.org/10.1089/jpm.2017.0159

Background Haloperidol is widely prescribed as an anti-emetic in patients receiving palliative care, but there is limited evidence to support and refine its use. Objective To explore the immediate and short-term net clinical effects of haloperidol wh... Read More

The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial: All-Wales licensed premises intervention (2017)
Journal Article
Moore, S. C., Alam, M. F., Heikkinen, M., Hood, K., Huang, C., Moore, L., …Williams, A. (2017). The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial: All-Wales licensed premises intervention. Addiction, 112(11), 1898-1906. https://doi.org/10.1111/add.13878

Background and Aims Premises licensed for the sale and consumption of alcohol can contribute to levels of assault‐related injury through poor operational practices that, if addressed, could reduce violence. We tested the real‐world effectiveness of... Read More