The effect of variations in muscle positions in a complex biomechanical model of a macaque skull
(2009)
Presentation / Conference Contribution
Shi, J., Fitton, L., Curtis, N., O'Higgins, P., & Fagan, M. The effect of variations in muscle positions in a complex biomechanical model of a macaque skull
All Outputs (164)
Mind the gap. A finite element study of the retromolar space and its relation to cortical thickness distribution in the mandibular ramus (2009)
Presentation / Conference Contribution
Gröning, F., O'Higgins, P., & Fagan, M. Mind the gap. A finite element study of the retromolar space and its relation to cortical thickness distribution in the mandibular ramus
Changing faces: an examination of robust craniofacial features in Macaca majori and implications for the hominid fossil record (2009)
Presentation / Conference Contribution
O'Higgins, P., & Fagan, M. Changing faces: an examination of robust craniofacial features in Macaca majori and implications for the hominid fossil record
Facial mechanics in early hominins: a study combining geometric morphometrics and finite elements analysis (2009)
Journal Article
Groening, F., Phillips, R., Cobb, S., & Fagan, M. (2009). Facial mechanics in early hominins: a study combining geometric morphometrics and finite elements analysis. American journal of physical anthropology, 138(48), 201 - 202
Visualising muscle anatomy using three-dimensional computer models - an example using the head and neck muscles of Sphenodon (2009)
Journal Article
Curtis, N., Jones, M. E., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2009). Visualising muscle anatomy using three-dimensional computer models - an example using the head and neck muscles of Sphenodon. Palaeontologia electronica, 12(3), Article 12.3.7TWe demonstrate how the computer-based technique of multi-body dynamics analysis (MDA) can be used to create schematic, but informative three-dimensional (3D) representations of complex muscle anatomy. As an example we provide an overview of the head... Read More about Visualising muscle anatomy using three-dimensional computer models - an example using the head and neck muscles of Sphenodon.
A single-channel telemetric intramedullary nail for in vivo measurement of fracture healing (2009)
Journal Article
Wilson, D. J., Morgan, R. L., Hesselden, K. L., Dodd, J. R., Janna, S. W., & Fagan, M. J. (2009). A single-channel telemetric intramedullary nail for in vivo measurement of fracture healing. Journal of orthopaedic trauma, 23(10), 702-709. https://doi.org/10.1097/bot.0b013e3181b01c49Objective: The objective of this study was to develop a single-channel telemetric intramedullary nail that measures anterior-posterior bending strains and determine whether these forces decrease sigmoidally when normalized to the ground reaction forc... Read More about A single-channel telemetric intramedullary nail for in vivo measurement of fracture healing.
Predicting muscle activation patterns from motion and anatomy: modelling the skull of Sphenodon (Diapsida: Rhynchocephalia) (2009)
Journal Article
Curtis, N., Jones, M. E., Evans, S. E., Shi, J., O'Higgins, P., & Fagan, M. J. (2010). Predicting muscle activation patterns from motion and anatomy: modelling the skull of Sphenodon (Diapsida: Rhynchocephalia). Journal of the Royal Society interface / the Royal Society, 7(42), 153-160. https://doi.org/10.1098/rsif.2009.0139The relationship between skull shape and the forces generated during feeding is currently under widespread scrutiny and increasingly involves the use of computer simulations such as finite element analysis. The computer models used to represent skull... Read More about Predicting muscle activation patterns from motion and anatomy: modelling the skull of Sphenodon (Diapsida: Rhynchocephalia).
Biomechanical assessment of evolutionary changes in the lepidosaurian skull (2009)
Journal Article
Moazen, M., Curtis, N., O'Higgins, P., Evans, S. E., & Fagan, M. J. (2009). Biomechanical assessment of evolutionary changes in the lepidosaurian skull. Proceedings of the National Academy of Sciences of the United States of America, 106(20), 8273-8277. https://doi.org/10.1073/pnas.0813156106The lepidosaurian skull has long been of interest to functional morphologists and evolutionary biologists. Patterns of bone loss and gain, particularly in relation to bars and fenestrae, have led to a variety of hypotheses concerning skull use and ki... Read More about Biomechanical assessment of evolutionary changes in the lepidosaurian skull.
Validating a voxel-based finite element model of a human mandible using digital speckle pattern interferometry (2009)
Journal Article
Gröning, F., Liu, J.-S., Fagan, M. J., & O'Higgins, P. (2009). Validating a voxel-based finite element model of a human mandible using digital speckle pattern interferometry. Journal of biomechanics, 42(9), 1224-1229. https://doi.org/10.1016/j.jbiomech.2009.03.025Finite element analysis is a powerful tool for predicting the mechanical behaviour of complex biological structures like bones, but to be confident in the results of an analysis, the model should be validated against experimental data. In such valida... Read More about Validating a voxel-based finite element model of a human mandible using digital speckle pattern interferometry.
γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior (2009)
Journal Article
McLeod, J., Curtis, N., Lewis, H. D., Good, M. A., Fagan, M. J., & Genever, P. G. (2009). γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior. FASEB Journal, 23(9), 2942-2955. https://doi.org/10.1096/fj.08-121657gamma-Secretase cleaves amyloid precursor protein (APP) to generate amyloid-beta (A beta) peptides, which aggregate in the brain in Alzheimer's disease (AD). gamma-Secretase also cleaves molecules that regulate osteoblast activity, such as Notch and... Read More about γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior.
Principal component analysis as a tool for analyzing beat-to-beat changes in ECG features: application to ECG-derived respiration (2009)
Journal Article
Langley, P., Bowers, E. J., & Murray, A. (2010). Principal component analysis as a tool for analyzing beat-to-beat changes in ECG features: application to ECG-derived respiration. IEEE transactions on bio-medical engineering / Bio-medical Engineering Group, 57(4), 821-829. https://doi.org/10.1109/TBME.2009.2018297An algorithm for analyzing changes in ECG morphology based on principal component analysis (PCA) is presented and applied to the derivation of surrogate respiratory signals from single-lead ECGs. The respiratory-induced variability of ECG features, P... Read More about Principal component analysis as a tool for analyzing beat-to-beat changes in ECG features: application to ECG-derived respiration.
Assessment of the role of sutures in a lizard skull: a computer modelling study (2009)
Journal Article
Moazen, M., Curtis, N., O'Higgins, P., Jones, M. E., Evans, S. E., & Fagan, M. J. (2009). Assessment of the role of sutures in a lizard skull: a computer modelling study. Proceedings of the Royal Society B: Biological Sciences, 276(1654), 39-46. https://doi.org/10.1098/rspb.2008.0863Sutures form an integral part of the functioning skull, but their role has long been debated among vertebrate morphologists and palaeontologists. Furthermore, the relationship between typical skull sutures, and those involved in cranial kinesis, is p... Read More about Assessment of the role of sutures in a lizard skull: a computer modelling study.
Masticatory loading and bone adaptation in the supraorbital torus of developing macaques (2008)
Journal Article
Kupczik, K., Dobson, C. A., Crompton, R. H., Phillips, R., Oxnard, C. E., Fagan, M. J., & O'Higgins, P. (2009). Masticatory loading and bone adaptation in the supraorbital torus of developing macaques. American journal of physical anthropology, 139(2), 193-203. https://doi.org/10.1002/ajpa.20972Research on the evolution and adaptive significance of primate craniofacial morphologies has focused on adult, fully developed individuals. Here, we investigate the possible relationship between the local stress environment arising from masticatory l... Read More about Masticatory loading and bone adaptation in the supraorbital torus of developing macaques.
Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O’Higgins, P., & Fagan, M. J. (2008). Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull. Journal of anatomy, 213(5), 499-508. https://doi.org/10.1111/j.1469-7580.2008.00980.xLizard skulls vary greatly in shape and construction, and radical changes in skull form during evolution have made this an intriguing subject of research. The mechanics of feeding have surely been affected by this change in skull form, but whether th... Read More about Combined finite element and multibody dynamics analysis of biting in aUromastyx hardwickiilizard skull.
The role of cranial sutures in a lizard skull : a finite element analysis investigation (2008)
Presentation / Conference Contribution
Moazen, M., Curtis, N., & Fagan, M. The role of cranial sutures in a lizard skull : a finite element analysis investigation
Predicting muscle forces and activation patterns during mastication : a multi-body computer modelling study of Spendon Punctatus (Lepidosauria : Rhynchocephalia) (2008)
Presentation / Conference Contribution
Shi, J., Curtis, N., & Fagan, M. Predicting muscle forces and activation patterns during mastication : a multi-body computer modelling study of Spendon Punctatus (Lepidosauria : Rhynchocephalia)
Musculoskeletal modelling of a macaque skull- sensitivity studies (2008)
Presentation / Conference Contribution
Shi, J., Fitton, L., Curtis, N., O'Higgins, P., & Fagan, M. Musculoskeletal modelling of a macaque skull- sensitivity studies
A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology (2008)
Journal Article
Griffin, R. C., Moody, H., Penkman, K. E. H., Fagan, M. J., Curtis, N., & Collins, M. J. (2008). A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology. Journal of Forensic Sciences, 53(4), 910-916. https://doi.org/10.1111/j.1556-4029.2008.00753.xAspartic acid racemization has been found to be an accurate measure of age at death for recent forensic material. This paper examines the practicality of using acid etching of the tooth surface to extract amino acids from the enamel for racemization... Read More about A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology.
Predicting skull loading: applying multibody dynamics analysis to a macaque skull (2008)
Journal Article
Curtis, N., Kupczik, K., O'Higgins, P., Moazen, M., & Fagan, M. (2008). Predicting skull loading: applying multibody dynamics analysis to a macaque skull. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 291(5), 491-501. https://doi.org/10.1002/ar.20689Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial and skeletal morphology to mechanical loading. Engineering techniques such as finite element analysis are now commonly us... Read More about Predicting skull loading: applying multibody dynamics analysis to a macaque skull.
Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii (2008)
Journal Article
Moazen, M., Curtis, N., Evans, S. E., O'Higgins, P., & Fagan, M. J. (2008). Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii. Journal of biomechanics, 41(6), 1274-1280. https://doi.org/10.1016/j.jbiomech.2008.01.012Lizard skulls vary greatly in their detailed morphology. Theoretical models and practical studies have posited a definite relationship between skull morphology and bite performance, but this can be difficult to demonstrate in vivo. Computer modelling... Read More about Rigid-body analysis of a lizard skull: modelling the skull of Uromastyx hardwickii.