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All Outputs (49)

Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies (2024)
Journal Article
Mukadam, N., Wolters, F. J., Walsh, S., Wallace, L., Brayne, C., Matthews, F. E., Sacuiu, S., Skoog, I., Seshadri, S., Beiser, A., Ghosh, S., & Livingston, G. (2024). Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. The Lancet. Public Health, 9(7), e443-e460. https://doi.org/10.1016/S2468-2667%2824%2900120-8

Background: Some cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time us... Read More about Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies.

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme (2024)
Journal Article
Martyr, A., Gamble, L. D., Hunt, A., Quinn, C., Morris, R. G., Henderson, C., Allan, L., Opdebeeck, C., Charlwood, C., Jones, R. W., Pentecost, C., Kopelman, M. D., Thom, J. M., Matthews, F. E., & Clare, L. (2024). Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme. BMC medicine, 22(1), Article 265. https://doi.org/10.1186/s12916-024-03492-y

Background: People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods: The participants... Read More about Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Soft power, cultural relations and conflict through Eurovision and other mega-events: a literature review (2024)
Report
Baker, C., Atkinson, D., Grabher, B., & Howcroft, M. (2024). Soft power, cultural relations and conflict through Eurovision and other mega-events: a literature review. British Council

First paragraph:
This literature review explores the significance of the Eurovision Song Contest for soft power strategies and cultural relations activities, especially at times of conflict and international aggression.

Culture, place and partnership: the cultural relations of Eurovision 2023 (2024)
Report
Baker, C., Atkinson, D., Grabher, B., & Howcroft, M. (2024). Culture, place and partnership: the cultural relations of Eurovision 2023. British Council

Foreword:
This report tells the story of the Eurovision Song Contest in 2023, when the UK found itself as host on behalf of the 2022 winners Ukraine, due to Russia’s full-scale invasion of the country in 2021. As the UK’s 2022 entry Sam Ryder put it... Read More about Culture, place and partnership: the cultural relations of Eurovision 2023.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., Jones, R. W., Collins, R., van Horik, J., Pentecost, C., Allan, L., & Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.

Conclusions (2022)
Book Chapter
Williams, T. M. (2022). Conclusions. In T. M. Williams, K. Samset, & G. Holst Volden (Eds.), The Front-end of Large Public Projects: Paradoxes and Ways Ahead (191-204). Taylor & Francis (Routledge). https://doi.org/10.4324/9781003257172-8

Projects are the key organisational form used to deliver transformational policy change and build new systems in the public sector. Traditional thinking has looked at the project as an exercise to carry out a defined task in a specific time, at a spe... Read More about Conclusions.

Project success (2022)
Book Chapter
Williams, T. M. (2022). Project success. In T. M. Williams, K. Samset, & G. Holst Volden (Eds.), The Front-end of Large Public Projects: Paradoxes and Ways Ahead (10-42). London: Taylor & Francis (Routledge). https://doi.org/10.4324/9781003257172-2

This chapter looks at the academic background to this question, dividing the idea of success into strategic and tactical success. It looks at the various paradoxes that accompany major public projects as criteria for success are developed. The combin... Read More about Project success.

Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis (2022)
Journal Article
Peters, R., Xu, Y., Fitzgerald, O., Aung, H. L., Beckett, N., Bulpitt, C., Chalmers, J., Forette, F., Gong, J., Harris, K., Humburg, P., Matthews, F. E., Staessen, J. A., Thijs, L., Tzourio, C., Warwick, J., Woodward, M., & Anderson, C. S. (2022). Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. European Heart Journal, 43(48), 4980-4990. https://doi.org/10.1093/eurheartj/ehac584

Aims Observational studies indicate U-shaped associations of blood pressure (BP) and incident dementia in older age, but randomized controlled trials of BP-lowering treatment show mixed results on this outcome in hypertensive patients. A pooled indiv... Read More about Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis.

A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study (2022)
Journal Article
Gamble, L. D., Parker, S., Quinn, C., Bennett, H. Q., Martyr, A., Sabatini, S., Pentecost, C., Collins, R., Dawson, E., Hunt, A., Allan, L., Burns, A., Litherland, R., Victor, C., Matthews, F. E., & Clare, L. (2022). A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study. Journal of Alzheimer's Disease, 88(2), 679-692. https://doi.org/10.3233/JAD-220221

Background: Social restriction measures imposed to curb the spread of COVID-19 in the United Kingdom impacted on carers of people with dementia, limiting access to support services and increasing perceived burden of caring. Few studies have compared... Read More about A Comparison of Well-Being of Carers of People with Dementia and Their Ability to Manage Before and During the COVID-19 Pandemic: Findings from the IDEAL Study.

Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism (2021)
Journal Article
Allison, C., Matthews, F. E., Ruta, L., Pasco, G., Soufer, R., Brayne, C., Charman, T., & Baron-Cohen, S. (2021). Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism. BMJ Paediatrics Open, 5(1), Article e000700. https://doi.org/10.1136/bmjpo-2020-000700

Objective This is a prospective population screening study for autism in toddlers aged 18-30 months old using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), with follow-up at age 4. Design Observational study. Setting Luton, Bedfordshire... Read More about Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism.

SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit (2021)
Journal Article
Earle, F., Huddlestone, J., Williams, T., Stock-Williams, C., van der Mijle-Meijer, H., de Vries, L., …Moore, G. (in press). SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit. Wind energy, https://doi.org/10.1002/we.2647

This paper describes the SPOWTT project. The intention of this project was to understand how sailing by crew transfer vessel (CTVs) to offshore wind farms affects the mental and physical wellbeing of individuals on board. The focus was on quantifying... Read More about SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit.

The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success (2021)
Journal Article
Ojiako, U., Petro, Y., Marshall, A., & Williams, T. (in press). The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success. Production planning & control, https://doi.org/10.1080/09537287.2021.1909168

Some studies suggest that organizational ambidexterity is best orchestrated through individual projects. However, stand-alone individual projects are relatively limited in scope, while suffering from susceptibilities to horizontal and vertical segmen... Read More about The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success.

Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study (2021)
Journal Article
Welsh, C. E., Matthews, F. E., & Jagger, C. (2021). Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study. The Lancet Regional Health Europe, 2, Article 100023. https://doi.org/10.1016/j.lanepe.2020.100023

Background: As society ages, promoting the health of the extra years of life is of paramount importance for health, social care and pension provision. Increases in life expectancy in the UK and elsewhere have slowed in recent years, but the reasons f... Read More about Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study.

Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia (2021)
Journal Article
Dodds, R. M., Murray, J. C., Granic, A., Hurst, C., Uwimpuhwe, G., Richardson, S., Brayne, C., Matthews, F. E., Sayer, A. A., Arthur, A., Baldwin, C., Barnes, L. E., Comas-Herrera, A., Dening, T., Forster, G., Harrison, S., Ince, P. G., Jagger, C., McKeith, I. G., Parry, B., …Woods, B. (2021). Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318. https://doi.org/10.1002/jcsm.12660

Background: Poor performance in the 5-chair stand test (5-CST) indicates reduced lower limb muscle strength. The 5-CST has been recommended for use in the initial assessment of sarcopenia, the accelerated loss of muscle strength and mass. In order to... Read More about Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia.

Dementia in the older population is associated with neocortex content of serum amyloid P component (2021)
Journal Article
Ellmerich, S., Taylor, G. W., Richardson, C. D., Minett, T., Schmidt, A. F., Brayne, C., Matthews, F. E., Ince, P. G., Wharton, S. B., & Pepys, M. B. (2021). Dementia in the older population is associated with neocortex content of serum amyloid P component. Brain Communications, 3(4), Article fcab225. https://doi.org/10.1093/braincomms/fcab225

Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer's disease and some other common dementias is not known. The normal human plasma protein, serum amyloid P component, a constituent of... Read More about Dementia in the older population is associated with neocortex content of serum amyloid P component.