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Randomised, double-blind, multi-centre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B Feasibility) (2020)
Journal Article
Higginson, I., Wilcock, A., Johnson, M., Bajwah, S., Currow, D., Lovell, N., …Brown, S. (2020). Randomised, double-blind, multi-centre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B Feasibility). Thorax, https://doi.org/10.1136/thoraxjnl-2019-213879

New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with a modified medical research council breathlessness scale score ≥3. Sixty-four patients w... Read More about Randomised, double-blind, multi-centre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B Feasibility).

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Crooks, M. G., Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., …Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness (2017)
Journal Article
Johnson, M. J., Yorke, J., Hansen-Flaschen, J., Lansing, R., Ekström, M., Similowski, T., & Currow, D. (2017). Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness. The European respiratory journal, 49(5), doi:10.1183/13993003.02277-2016

Copyright ©ERS 2017. Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researc... Read More about Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness.


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