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Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (in press). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 1-5. doi:10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., …Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. The European respiratory journal, 52(5), 1801138. doi:10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study (2017)
Journal Article
Allen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., …Jenkins, R. . G. (2017). Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. The lancet. Respiratory medicine, 5(11), 869-880. doi:10.1016/s2213-2600(17)30387-9

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause and limited treatment options. Recent studies have identified a significant genetic risk associated with the development of IPF... Read More

A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial (2017)
Journal Article
Birring, S. S., Wijsenbeek, M. S., Agrawal, S., van den Berg, J. W., Stone, H., Maher, T. M., …Morice, A. (2017). A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial. The lancet. Respiratory medicine, 5(10), 806-815. doi:10.1016/S2213-2600(17)30310-7

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher dr... Read More

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study (2017)
Journal Article
Walsh, S. L., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., …Wells, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. The European respiratory journal, 50(2), doi:10.1183/13993003.00936-2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts p... Read More

Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness (2017)
Journal Article
Johnson, M. J., Yorke, J., Hansen-Flaschen, J., Lansing, R., Ekström, M., Similowski, T., & Currow, D. (2017). Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness. The European respiratory journal, 49(5), doi:10.1183/13993003.02277-2016

Copyright ©ERS 2017. Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researc... Read More

British Lung Foundation/United Kingdom primary immunodeficiency network consensus statement on the definition, diagnosis, and management of granulomatous-lymphocytic interstitial lung disease in common variable immunodeficiency disorders (2017)
Journal Article
Hurst, J. R., Verma, N., Lowe, D., Baxendale, H. E., Jolles, S., Kelleher, P., …Condliffe, A. M. (2017). British Lung Foundation/United Kingdom primary immunodeficiency network consensus statement on the definition, diagnosis, and management of granulomatous-lymphocytic interstitial lung disease in common variable immunodeficiency disorders. The journal of allergy and clinical immunology. In practice, 5(4), 938-945. doi:10.1016/j.jaip.2017.01.021

A proportion of people living with common variable immunodeficiency disorders develop granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a consensus statement on the definition, diagnosis, and management of GLILD. All UK... Read More

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? (2017)
Journal Article
Fowles, H. E., Rowland, T., Wright, C., & Morice, A. (2017). Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?. The European respiratory journal, 49(2), doi:10.1183/13993003.01452-2016. ISSN 0903-1936

Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensiti... Read More

The online Cough Clinic: Developing guideline-based diagnosis and advice (2009)
Journal Article
Dettmar, H. J., Fathi, H., Dettmar, P. W., Strugala, V., Wright, C., & Morice, A. H. (2009). The online Cough Clinic: Developing guideline-based diagnosis and advice. The European respiratory journal, 34(4), 819-824. doi:10.1183/09031936.00126908

The aim of the present study was make chronic cough guidelines more practical and user friendly by developing an internet-based interactive diagnostic questionnaire for chronic cough. A prospective cohort study of chronic cough sufferers was conducte... Read More

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4 (2007)
Journal Article
Ramachandran, R., Sadofsky, L., Xiao, Y., Botham, A., Cowen, M., Morice, A., & Compton, S. J. (2007). Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. American journal of physiology. Lung cellular and molecular physiology, 292(3), L788-L798. doi:10.1152/ajplung.00226.2006

Human lung fibroblasts express proteinase-activated receptor-1 (PAR 1 ), PAR 2 and PAR 3 , but not PAR 4 . Because PAR 2 has inflammatory effects on human primary bronchial fibroblasts (HPBF), we asked 1) whether the inflammatory mediators TNF-α and... Read More