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Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging (2022)
Journal Article
Scialla, S., Genicio, N., Brito, B., Florek-Wojciechowska, M., Stasiuk, G. J., Kruk, D., …Gallo, J. (2022). Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging. ACS Applied Nano Materials, 5(11), 16462–16474. https://doi.org/10.1021/acsanm.2c03537

The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions... Read More about Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging.

Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., …Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.

Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties (2020)
Journal Article
Alshamrani, A. F. A., Santoro, O., Ounsworth, S., Prior, T. J., Stasiuk, G. J., & Redshaw, C. (2021). Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties. Polyhedron, 195, Article 114977. https://doi.org/10.1016/j.poly.2020.114977

The treatment of CuX2 (X = Cl, Br) with an equimolar amount of 2-2ʹ-diphenylglycine (DpgH) in EtOH at reflux afforded, after work up, the complexes [CuCl(Dpg)(EtOH)]2 (1) and [(CuBr2)2(Dpg)2Cu(EtOH)4] (2), respectively. The compounds were obtained mi... Read More about Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties.

Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics (2020)
Journal Article
Yap, S. Y., Savoie, H., Renard, I., Burke, B. P., Sample, H. C., Michue-Seijas, S., …Stasiuk, G. J. (2020). Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics. Chemical communications : Chem comm / the Royal Society of Chemistry, 56(75), 11090-11093. https://doi.org/10.1039/d0cc03958f

© The Royal Society of Chemistry 2020. The goal of “personalised” medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chel... Read More about Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics.

Evaluation of a bispidine‐based chelator for gallium‐68 and of the porphyrin conjugate as PET/PDT theranostic agent (2020)
Journal Article
Price, T., Yap, S. Y., Gillet, R., Savoie, H., Charbonnière, L. J., Boyle, R. W., …Stasiuk, G. J. (2020). Evaluation of a bispidine‐based chelator for gallium‐68 and of the porphyrin conjugate as PET/PDT theranostic agent. Chemistry: a European journal, 26(34), 7602-7608. https://doi.org/10.1002/chem.201905776

In this study a bispidine ligand has been applied to the complexation of gallium(III) and radiolabelled with gallium-68 for the first time. Despite its 5-coordinate nature, the resulting complex is stable in serum for over two hours, demonstrating a... Read More about Evaluation of a bispidine‐based chelator for gallium‐68 and of the porphyrin conjugate as PET/PDT theranostic agent.

Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O–, NH–): Structural and Cytotoxicity Studies (2020)
Journal Article
Alshamrani, A. F., Prior, T. J., Burke, B. P., Roberts, D. P., Archibald, S. J., Higham, L. J., …Redshaw, C. (2020). Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O–, NH–): Structural and Cytotoxicity Studies. Inorganic chemistry, 59(4), 2367-2378. https://doi.org/10.1021/acs.inorgchem.9b03239

Reaction of [ReOCl3(PPh3)2] or [ReO2I(PPh3)2] with 2,2′-diphenylglycine (dpgH2) in refluxing ethanol afforded the air-stable complex [ReO(dpgH)(dpg)(PPh3)] (1). Treatment of [ReO(OEt)I2(PPh3)2] with 1,2,3-triaza-7-phosphaadamantane (PTA) afforded the... Read More about Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O–, NH–): Structural and Cytotoxicity Studies.

Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units (2020)
Journal Article
Chabloz, N., Perry, H., Yoon, I., Coulson, A., White, A., Stasiuk, G., …Wilton-Ely, J. (in press). Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units. Chemistry: a European journal, https://doi.org/10.1002/chem.201904757

A robust dithiocarbamate tether allows novel gadolinium units based on DOTAGA (q = 1) to be attached to the surface of gold nanoparticles (2.6 ‐ 4.1 nm diameter) along with functional units offering biocompatibility, targeting and photodynamic therap... Read More about Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units.

Long-term ambient air-stable cubic CsPbBr3 perovskite quantum dots using molecular bromine (2019)
Journal Article
Thapa, S., Bhardwaj, K., Basel, S., Pradhan, S., Eling, C. J., Adawi, A. M., …Tamang, S. (2019). Long-term ambient air-stable cubic CsPbBr3 perovskite quantum dots using molecular bromine. Nanoscale advances, 1(9), 3388-3391. https://doi.org/10.1039/c9na00486f

We report unprecedented phase stability of cubic CsPbBr3 quantum dots in ambient air obtained by using Br2 as halide precursor. Mechanistic investigation reveals the decisive role of temperature-controlled in situ generated, oleylammonium halide spec... Read More about Long-term ambient air-stable cubic CsPbBr3 perovskite quantum dots using molecular bromine.

Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI (2019)
Journal Article
Nicolas, C., Wenzel, M., Perry, H., Yoon, I., Molisso, S., Stasiuk, G., …Wilton-Ely, J. (in press). Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI. Chemistry: a European journal, https://doi.org/10.1002/chem.201901820

The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robu... Read More about Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI.

Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion (2019)
Journal Article
Clarke, M. T., Viscomi, F. N., Chamberlain, T. W., Hondow, N., Adawi, A. M., Sturge, J., …Stasiuk, G. J. (2019). Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion. Communications Chemistry, 2(1), Article 36. https://doi.org/10.1038/s42004-019-0138-z

© 2019, The Author(s). Indium phosphide based quantum dots have emerged in recent years as alternatives to traditional heavy metal (cadmium, lead) based materials suitable for biomedical application due to their non-toxic nature. The major barrier to... Read More about Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion.

Selective radiolabelling with 68Ga under mild conditions: a route towards a porphyrin PET/PDT theranostic agent (2018)
Journal Article
Yap, S. Y., Price, T. W., Savoie, H., Boyle, R. W., & Stasiuk, G. J. (2018). Selective radiolabelling with 68Ga under mild conditions: a route towards a porphyrin PET/PDT theranostic agent. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(57), 7952-7954. https://doi.org/10.1039/c8cc03897j

A theranostic conjugate for use as a positron emission tomography (PET) radiotracer and as a photosensitiser for photodynamic therapy (PDT) has been synthesised. A water-soluble porphyrin was coupled with the bifunctional chelate, H4Dpaa.ga. This con... Read More about Selective radiolabelling with 68Ga under mild conditions: a route towards a porphyrin PET/PDT theranostic agent.

A 18F radiolabelled Zn(ii) sensing fluorescent probe (2018)
Journal Article
Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. https://doi.org/10.1039/c8cc00687c

A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ... Read More about A 18F radiolabelled Zn(ii) sensing fluorescent probe.

Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH (2017)
Journal Article
Kubicek, V., Bohmova, Z., Price, T. W., Gallo, J., Kubíček, V., Böhmová, Z., …Stasiuk, G. J. (2017). Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH. Dalton Transactions : an international journal of inorganic chemistry, 46(48), 16973-16982. https://doi.org/10.1039/c7dt03398b

Gallium-68 ( 68 Ga) has been the subject of increasing interest for its potential in the production of radiotracers for diagnosis of diseases. In this work we report the complexation of 68 Ga by the amino acid based tripodal chelate H 3 Dpaa, and two... Read More about Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH.

How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases (2016)
Journal Article
Rodriguez-Teja, M., Breit, C., Clarke, M., Talar, K., Wang, K., Mohammad, M. A., …Sturge, J. (2016). How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases. Journal of visualized experiments : JoVE, 2016(115), https://doi.org/10.3791/54230

Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvasc... Read More about How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases.

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes (2016)
Journal Article
Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), 4977-4987. https://doi.org/10.1039/c6ce00209a

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure d... Read More about Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes.

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc (2016)
Journal Article
Price, T. W., Greenman, J., & Stasiuk, G. J. (2016). Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc. Dalton Transactions : an international journal of inorganic chemistry, 45(40), 15702-15724. https://doi.org/10.1039/c5dt04706d

A key part of the development of metal based Positron Emission Tomography probes is the chelation of the radiometal. In this review the recent developments in the chelation of four positron emitting radiometals, 68Ga, 64Cu, 89Zr and 44Sc, are explore... Read More about Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc.

Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system (2015)
Journal Article
Keasberry, N. A., Bañobre-López, M., Wood, C., Stasiuk, G. J., Gallo, J., & Long, N. J. (2015). Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system. Nanoscale, 7(38), 16119-16128. https://doi.org/10.1039/c5nr04400f

Magnetic resonance imaging (MRI) is an excellent imaging modality. However the low sensitivity of the technique poses a challenge to achieving an accurate image of function at the molecular level. To overcome this, contrast agents are used; typically... Read More about Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system.

⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation (2015)
Journal Article
Stasiuk, G. J., Holloway, P. M., Rivas, C., Trigg, W., Luthra, S. K., Morrison Iveson, V., …Long, N. J. (2015). ⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4986-4993. https://doi.org/10.1039/c4dt02980a

Non-invasive imaging of the inflammatory process can provide a great deal of insight into a wide variety of diseases states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, thr... Read More about ⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation.

Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions (2014)
Journal Article
Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4976-4985. https://doi.org/10.1039/c4dt02981j

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and... Read More about Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions.

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging (2013)
Journal Article
Rivas, C., Stasiuk, G. J., Gallo, J., Minuzzi, F., Rutter, G. A., & Long, N. J. (2013). Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging. Inorganic chemistry, 52(24), 14284-14293. https://doi.org/10.1021/ic402233g

Two novel dual-modal MRI/optical probes based on a rhodamine-DO3A conjugate have been prepared. The bis aqua-Gd(III) complex Gd.L1 and mono aqua-Gd(III) complex Gd.L2 behave as dual-modal imaging probes (r1 = 8.5 and 3.8 mM-1s-1 for Gd.L1 and Gd.L2 r... Read More about Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging.