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Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS) (2017)
Journal Article
Kingston, A., Wohland, P., Wittenberg, R., Robinson, L., Brayne, C., Matthews, F. E., & Jagger, C. (2017). Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). Lancet, 390(10103), 1676-1684. https://doi.org/10.1016/S0140-6736%2817%2931575-1

Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care. Methods: Tw... Read More about Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS).

Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis (2016)
Journal Article
Zhang, J., Dierckx, R., Mohee, K., Clark, A. L., & Cleland, J. G. (2017). Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Failure, 4(1), 40-45. https://doi.org/10.1002/ehf2.12112

Background Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required. Methods and results We published a meta-analysis of trials conducted bef... Read More about Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.

The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm (2015)
Journal Article
IMPROVE Trial Investigators. (2015). The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm. European Heart Journal, 36(21), 1328-1334. https://doi.org/10.1093/eurheartj/ehu521

Aims To investigate whether aneurysm shape and extent, which indicate whether a patient with ruptured abdominal aortic aneurysm (rAAA) is eligible for endovascular repair (EVAR), influence the outcome of both EVAR and open surgical repair. Methods an... Read More about The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm.

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 (2011)
Journal Article
Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., …Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not cl... Read More about Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.