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Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study (2015)
Journal Article
George, A., Bhatia, R. T., Buchanan, G. L., Whiteside, A., Moisey, R. S., Beer, S. F., …John, J. (2015). Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study. PLoS ONE, 10(11), e0142045. https://doi.org/10.1371/journal.pone.0142045

Objective To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI). Research Design and Methods Retrospective cohort study of 768 patients without preexisting... Read More about Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study.

Infection in prosthetic material (2015)
Journal Article
Smith, G., & Chetter, I. (2015). Infection in prosthetic material. Surgery (Oxford), 33(11), 559-564. https://doi.org/10.1016/j.mpsur.2015.08.003

Surgical site infection (SSI) occurs when a wound created as part of a surgical procedure becomes infected. SSI is one of the most common healthcare-associated infections and occurs in approximately 5% of patients undergoing a surgical procedure. SSI... Read More about Infection in prosthetic material.

A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation (2015)
Journal Article
Barnes, R., Smith, G. E., & Chetter, I. C. (2015). A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation. The journal of vascular access, 16(5), 372-376. https://doi.org/10.5301/jva.5000401

Purpose: Arteriovenous fistula (AVF) surgery affords an excellent opportunity for junior surgeons to learn key vascular techniques. However, implementation of the European Working Time Directive has reduced trainee surgeon’s working hours, leading to... Read More about A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation.

Defining chronic cough: A systematic review of the epidemiological literature (2015)
Journal Article
Song, W. J., Chang, Y. S., Faruqi, S., Kang, M. K., Kim, J. Y., Kang, M. G., …Morice, A. H. (2016). Defining chronic cough: A systematic review of the epidemiological literature. Allergy Asthma and Immunology Research, 8(2), 146-155. https://doi.org/10.4168/aair.2016.8.2.146

© The Korean Academy of Asthma, Allergy and Clinical Immunology. Purpose: Recent evidence suggests a global burden of chronic cough in general populations. However, the definitions vary greatly among epidemiological studies, and none have been valida... Read More about Defining chronic cough: A systematic review of the epidemiological literature.

A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication (2015)
Journal Article
Harwood, A., Cayton, T., Sarvanandan, R., Lane, R., & Chetter, I. (2016). A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication. Annals of vascular surgery, 30, 312-320. https://doi.org/10.1016/j.avsg.2015.05.043

© 2016 Elsevier Inc. All rights reserved. Background Intermittent claudication (IC) is a common condition which is associated with significant quality of life limitation. National Institute for Health and Care Excellence guidelines recommend a group-... Read More about A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication.

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008 (2015)
Journal Article
Tataru, D., Jack, R. H., Lind, M. J., Møller, H., & Lüchtenborg, M. (2015). The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008. Cancer epidemiology, 39(4), 612-616. https://doi.org/10.1016/j.canep.2015.04.008

A large proportion of lung cancer patients in England are diagnosed through an emergency route, which is associated with poorer outcomes. Here, we investigated the association between emergency presentation and the odds of undergoing surgical resecti... Read More about The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008.

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable' (2015)
Journal Article
Morgan, K., Sadofsky, L. R., & Morice, A. H. (2015). Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Bioscience Reports, 35(5), Article e00255. https://doi.org/10.1042/BSR20150108

© 2015 Authors. Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signallin... Read More about Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Objective measurement of cough frequency during COPD exacerbation convalescence (2015)
Journal Article
Crooks, M. G., Hayman, Y., Innes, A., Williamson, J., Wright, C. E., & Morice, A. H. (2016). Objective measurement of cough frequency during COPD exacerbation convalescence. Lung, 194(1), 117-120. https://doi.org/10.1007/s00408-015-9782-y

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective co... Read More about Objective measurement of cough frequency during COPD exacerbation convalescence.

A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis (2015)
Journal Article
Smith, G. E., Souroullos, P., Cayton, T., Harwood, A., Carradice, D., & Chetter, I. C. (2016). A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis. The journal of vascular access, 17(1), 1-5. https://doi.org/10.5301/jva.5000484

Purpose: Surgical arteriovenous fistula (AVF) or graft (AVG) is preferred to a central venous catheter for dialysis access. Surgical access may suffer thrombosis early after placement and systemic anticoagulation during surgical access formation may... Read More about A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis.

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial (2015)
Journal Article
Valle, J. W., Wasan, H., Lopes, A., Backen, A. C., Palmer, D. H., Morris, K., …Bridgewater, J. A. (2015). Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial. The lancet oncology, 16(8), 967-978. https://doi.org/10.1016/S1470-2045%2815%2900139-4

© 2015 Valle et al. Open Access article distributed under the terms of CC BY. Background: Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors... Read More about Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.

Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm (2015)
Journal Article
Chetter, I., Sweeting, M., Balm, R., Desgranges, P., Ulug, P., Powell, J., & Ruptured Aneurysm Trialists. (2015). Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm. British journal of surgery, 102(10), 1229-1239. https://doi.org/10.1002/bjs.9852

BackgroundThe benefits of endovascular repair of ruptured abdominal aortic aneurysm remain controversial, without any strong evidence about advantages in specific subgroups.MethodsAn individual-patient data meta-analysis of three recent randomized tr... Read More about Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm.

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial (2015)
Journal Article
Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., …Price, D. (2015). Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial. Trials, 16(1), Article 267. https://doi.org/10.1186/s13063-015-0782-2

© Devereux et al. Background: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Pre... Read More about Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial.

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot (2015)
Journal Article
Johnson, M. J., Simpson, M. I., Currow, D. C., Millman, R. E., Hart, S. P., & Green, G. (2015). Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot. BMJ open, 5(6), Article ARTN e007535. https://doi.org/10.1136/bmjopen-2014-007535

Objectives: Neuroimaging in chronic breathlessness is challenging. The study objective was to test the feasibility of magnetoencephalography (MEG) for functional neuroimaging of people with chronic breathlessness. Design: Feasibility pilot study. Set... Read More about Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: A feasibility pilot.

Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial (2015)
Journal Article
Braithwaite, B., Greenhalgh, R. M., Grieve, R., Hassan, T. B., Moore, F., Nicholson, A. A., …Wilson, L. (2015). Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial. European Heart Journal, 36(31), 2061-2069. https://doi.org/10.1093/eurheartj/ehv125

© 2015 The Author. Aims To report the longer term outcomes following either a strategy of endovascular repair first or open repair of ruptured abdominal aortic aneurysm, which are necessary for both patient and clinical decision-making. Methods and r... Read More about Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: One-year outcomes from the IMPROVE randomized trial.

A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins (2015)
Journal Article
Nandhra, S., El-sheikha, J., Carradice, D., Wallace, T., Souroullas, P., Samuel, N., …Chetter, I. C. (2015). A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins. Journal of vascular surgery, 61(3), 741-746. https://doi.org/10.1016/j.jvs.2014.09.037

Background: This randomized clinical trial compared endovenous laser ablation (EVLA) and surgical ligation with attempted stripping in the treatment of small saphenous vein (SSV) insufficiency. The early results demonstrated that EVLA was more likely... Read More about A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins.

The Impact of Chronic Cough: A Cross-Sectional European Survey (2015)
Journal Article
Chamberlain, S. A., Garrod, R., Douiri, A., Masefield, S., Powell, P., Bücher, C., …Birring, S. S. (2015). The Impact of Chronic Cough: A Cross-Sectional European Survey. Lung, 193(3), 401-408. https://doi.org/10.1007/s00408-015-9701-2

© 2015, Springer Science+Business Media New York. Purpose: Studies that investigate the impact of chronic cough have largely focused on patients attending secondary care. Our aim was to investigate the opinions of the wider general population across... Read More about The Impact of Chronic Cough: A Cross-Sectional European Survey.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., …Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland (2015)
Journal Article
El-Sheikha, J., Nandhra, S., Carradice, D., Acey, C., Smith, G., Campbell, B., & Chetter, I. (2016). Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland. Phlebology, 31(1), 16-22. https://doi.org/10.1177/0268355514567732

Introduction: The optimal compression regime following ultrasound guided foam sclerotherapy (UGFS), radiofrequency ablation (RFA) and endovenous laser ablation (EVLA) for varicose veins is not known. The aim of this study was to document current prac... Read More about Compression regimes after endovenous ablation for superficial venous insufficiency – A survey of members of the Vascular Society of Great Britain and Ireland.

The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study (2015)
Journal Article
Hamad, G. A., Crooks, M., & Morice, A. H. (2016). The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study. Health Informatics Journal, 22(2), 406-413. https://doi.org/10.1177/1460458214564434

© 2014 The Author(s). We aim to establish the value of telemonitoring in the early detection of chronic obstructive pulmonary disease exacerbations. We followed up patients undergoing chronic obstructive pulmonary disease telemonitoring for 4 months.... Read More about The value of telehealth in the early detection of chronic obstructive pulmonary disease exacerbations: A prospective observational study.