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All Outputs (39)

Tailored risk assessment and forecasting in intermittent claudication (2024)
Journal Article
Ravindhran, B., Prosser, J., Lim, A., Lathan, R., Hitchman, L., Mishra, B., …Chetter, I. (2024). Tailored risk assessment and forecasting in intermittent claudication. BJS Open, 8(1), Article zrad166. https://doi.org/10.1093/bjsopen/zrad166

Background Guidelines recommend cardiovascular risk reduction and supervised exercise therapy as the first line of treatment in intermittent claudication, but implementation challenges and poor patient compliance lead to significant variation in man... Read More about Tailored risk assessment and forecasting in intermittent claudication.

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., …Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.

Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation (2023)
Journal Article
Gordon, H., Hebenton, J., Davie-Smith, F., Twiddy, M., Smith, G., & Carradice, D. (2023). Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation. Journal of Vascular Societies Great Britain and Ireland, 2(4), 208-214. https://doi.org/10.54522/jvsgbi.2023.081

Background: Through knee amputation (TKA) may offer benefits over above knee amputation (AKA) in patients unsuitable for below knee amputation. This retrospective analysis compared surgical and rehabilitation outcomes post TKA and AKA. Methods: Al... Read More about Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation.

Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials (2023)
Journal Article
Sidebottom, D. B., Huang, C., Carradice, D., Holt, P. J., John-Pierre, K., & Roy, I. N. (2023). Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials. BMJ open, 13(8), Article e072355. https://doi.org/10.1136/bmjopen-2023-072355

INTRODUCTION: The optimal antithrombotic regimen to reduce the risk of vascular events in patients with peripheral arterial disease (PAD) is contentious. This systematic review and network meta-analysis (NMA) aims to define the relative efficacy and... Read More about Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials.

PRESS survey: PREvention of surgical site infection—a global pan-specialty survey of practice protocol (2023)
Journal Article
Heinz, J., Walshaw, J., Kwan, J. Y., Long, J., Carradice, D., Totty, J., …Yiasemidou, M. (2023). PRESS survey: PREvention of surgical site infection—a global pan-specialty survey of practice protocol. Frontiers in Surgery, 10, Article 1251444. https://doi.org/10.3389/fsurg.2023.1251444

Background: Surgical site infections (SSI) complicate up to 40% of surgical procedures, leading to increased patient morbidity and mortality. Previous research identified disparities in SSI prevention guidelines and clinical practices across differen... Read More about PRESS survey: PREvention of surgical site infection—a global pan-specialty survey of practice protocol.

Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience (2022)
Journal Article
Ravindhran, B., Totty, J. P., Sidapra, M., Lathan, R., Carradice, D., Chetter, I. C., & Smith, G. E. (in press). Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience. The journal of vascular access, https://doi.org/10.1177/11297298221141497

Background: The reduction in distal arterial flow following arteriovenous fistula (AVF) creation can cause a perfusion deficit known as haemodialysis access induced distal ischemia (HAIDI). Various techniques have been advocated to treat this difficu... Read More about Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience.

Provision of NICE-recommended varicose vein treatment in the NHS (2022)
Journal Article
Hitchman, L., Mohamed, A., Smith, G. E., Pymer, S., Chetter, I. C., Forsyth, J., & Carradice, D. (2023). Provision of NICE-recommended varicose vein treatment in the NHS. British journal of surgery, 110(2), 225-232. https://doi.org/10.1093/bjs/znac392

BACKGROUND: Standardization of access to treatment and compliance with clinical guidelines are important to ensure the delivery of high-quality care to people with varicose veins. In the National Health Service (NHS) in England, commissioning of care... Read More about Provision of NICE-recommended varicose vein treatment in the NHS.

Research priorities for venous conditions: results of the UK Vascular James Lind Alliance Priority Setting Process (2022)
Journal Article
Long, J., Atkin, L., Gronlund, T., Lane, T., Nandhra, S., Wilton, E., …Vascular Society of Great Britain and Ireland Venous Special Interest Group. (2022). Research priorities for venous conditions: results of the UK Vascular James Lind Alliance Priority Setting Process. Journal of Vascular Societies Great Britain and Ireland, 2(1), 26-32. https://doi.org/10.54522/jvsgbi.2022.038

Introduction: Venous disease comprises a range of conditions of varying severity, which can result in pain and discomfort and a reduced quality of life. The annual costs for the treatment and management of venous disease in the UK is in the order of... Read More about Research priorities for venous conditions: results of the UK Vascular James Lind Alliance Priority Setting Process.

Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis (2022)
Journal Article
Ravindhran, B., Lathan, R., Staniland, T., Sidapra, M., Carradice, D., Chetter, I., …Pymer, S. (2022). Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(1), 41-45. https://doi.org/10.54522/jvsgbi.2022.042

Background and objectives: The aim of this systematic review is to explore the current evidence surrounding the changes in functional status following open or endovascular abdominal aortic aneurysm (AAA) repair and the role of postoperative exercise-... Read More about Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis.

Compression following treatment of superficial venous incompetence: systematic review (2022)
Journal Article
Mohamed, A. H., Thadani, S., Mohamed, S. H., Sidapra, M., Smith, G., Chetter, I., & Carradice, D. (2022). Compression following treatment of superficial venous incompetence: systematic review. British journal of surgery, 109(8), 679-685. https://doi.org/10.1093/bjs/znac116

BACKGROUND: International guidelines recommend postprocedural compression when treating symptomatic superficial venous incompetence (SVI). This updated review of RCTs investigated the requirement for postprocedural compression and how it can be appli... Read More about Compression following treatment of superficial venous incompetence: systematic review.

Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study (2022)
Journal Article
Prabakaran, P., Totty, J., Carradice, D., Chetter, I., & Smith, G. (in press). Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study. Journal of Wound Care,

Aims This study aimed to investigate the effects of a Single use Negative Pressure Wound Therapy (sNPWT) device upon tissue perfusion, oxygenation and pressure, in the intact skin of healthy volunteers. Methods 12 healthy volunteers wore a PIC... Read More about Measurement of the local physiological effects of a single use topical negative pressure device in healthy volunteers– The PICO-1 Study.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial (2020)
Journal Article
Gohel, M. S., Mora, MSc, J., Szigeti, M., Epstein, D. M., Heatley, F., Bradbury, A., …Davies, A. H. (in press). Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial. JAMA Surgery, https://doi.org/10.1001/jamasurg.2020.3845

Importance One-year outcomes from the Early Venous Reflux Ablation (EVRA) randomized trial showed accelerated venous leg ulcer healing and greater ulcer-free time for participants who are treated with early endovenous ablation of lower extremity sup... Read More about Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial.

A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access (2020)
Journal Article
Eves, J., Cai, P., Latham, R., Leung, C., Carradice, D., Chetter, I., & Smith, G. (in press). A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access. The journal of vascular access, https://doi.org/10.1177/1129729820954725

Background: Arteriovenous fistulae (AVF) are preferred for dialysis access but require accurate cannulation for effective dialysis. Evidence supports improvements in cannulation and complication rates using ultrasound guidance (USG) in cannulating ot... Read More about A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access.

A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride-coated dressings versus standard care for the primary prevention of surgical site infection (2019)
Journal Article
Totty, J. P., Hitchman, L. H., Cai, P. L., Wallace, T., Harwood, A. E., Carradice, D., …Chetter, I. C. (2019). A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride-coated dressings versus standard care for the primary prevention of surgical site infection. International wound journal, 16(4), 883-890. https://doi.org/10.1111/iwj.13113

A surgical site infection (SSI) may occur in up to 30% of procedures and results in significant morbidity and mortality. We aimed to assess the feasibility of conducting a randomised controlled trial (RCT) examining the use of dialkylcarbamoylchlorid... Read More about A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride-coated dressings versus standard care for the primary prevention of surgical site infection.

Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication (2018)
Journal Article
Harwood, A. E., Totty, J. P., Pymer, S., Huang, C., Hitchman, L., Carradice, D., …Chetter, I. C. (2019). Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication. Journal of vascular surgery, 69(6), 1899-1908.e1. https://doi.org/10.1016/j.jvs.2018.10.065

Objective Intermittent claudication occurs in 20 % of the population over 70 and treatment includes a supervised exercise programme (SEP). Whilst there is evidence demonstrating walking improvements following a SEP there is conflicting data on the ph... Read More about Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication.

A Randomized Trial of Early Endovenous Ablation in Venous Ulceration (2018)
Journal Article
Gohel, M. S., Heatley, F., Liu, X., Bradbury, A., Bulbulia, R., Cullum, N., …Davies, A. H. (2018). A Randomized Trial of Early Endovenous Ablation in Venous Ulceration. New England Journal of Medicine, 378(22), 2105-2114. https://doi.org/10.1056/nejmoa1801214

BACKGROUND Venous disease is the most common cause of leg ulceration. Although compression therapy improves venous ulcer healing, it does not treat the underlying causes of venous hypertension. Treatment of superficial venous reflux has been shown t... Read More about A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.

Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial) (2017)
Journal Article
Harwood, A. E., Smith, G. E., Totty, J. P., Carradice, D., Chetter, I. C., Harwood, A., …Smith, G. (2017). Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial). Trials, 18(1), https://doi.org/10.1186/s13063-017-1844-4

© 2017 The Author(s). Background: Peripheral arterial disease (PAD) has a population prevalence of 4.6% with intermittent claudication (IC) presenting as one of the earliest and most common symptoms. PAD has detrimental effects on patients' walking a... Read More about Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial).

Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review (2017)
Journal Article
Totty, J., Bua, N., Smith, G., Harwood, A., Carradice, D., Wallace, T., & Chetter, I. (2017). Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review. Journal of Wound Care, 26(3), 107-114. https://doi.org/10.12968/jowc.2017.26.3.107

Objective: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care profe... Read More about Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review.