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All Outputs (16)

Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR (2022)
Journal Article
Saldanha, P. A., Bolanle, I. O., Palmer, T. M., Nikitenko, L. L., & Rivero, F. (2022). Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR. Cells, 11(15), Article 2315. https://doi.org/10.3390/cells11152315

The myosin light chain phosphatase target subunit 1 (MYPT1), encoded by the PPP1R12A gene, is a key component of the myosin light chain phosphatase (MLCP) protein complex. MYPT1 isoforms have been described as products of the cassette-type alternativ... Read More about Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR.

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms (2019)
Journal Article
Featherby, S., Xiao, Y. P., Ettelaie, C., Nikitenko, L. L., Greenman, J., & Maraveyas, A. (2019). Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Scientific reports, 9(1), Article 6272. https://doi.org/10.1038/s41598-019-42738-1

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set... Read More about Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

MEF2 transcription factors are key regulators of sprouting angiogenesis (2016)
Journal Article
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., …De Val, S. (2016). MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes & development, 30(20), 2297-2309. https://doi.org/10.1101/gad.290619.116

© 2016 Sacilotto et al. Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within specific compartments of the endothelium. However, the molecular links be... Read More about MEF2 transcription factors are key regulators of sprouting angiogenesis.

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis (2013)
Journal Article
Nikitenko, L. L., Leek, R., Henderson, S., Pillay, N., Turley, H., Generali, D., …Fox, S. B. (2013). The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research, 19(20), 5740-5748. https://doi.org/10.1158/1078-0432.CCR-13-1712

Purpose: The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We therefore... Read More about The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema (2013)
Journal Article
Nikitenko, L. L., Shimosawa, T., Henderson, S., Mäkinen, T., Shimosawa, H., Qureshi, U., …Boshoff, C. (2013). Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. Journal of Investigative Dermatology, 133(7), 1768-1776. https://doi.org/10.1038/jid.2013.47

Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the Adm gene (adrenome... Read More about Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair (2011)
Journal Article
Maybin, J. A., Battersby, S., Hirani, N., Nikitenko, L. L., Critchley, H. O., & Jabbour, H. N. (2011). The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair. Endocrinology, 152(7), 2845-2856. https://doi.org/10.1210/en.2010-1256

After menstruation, the endometrium has a remarkable capacity for repair, but the factors involved remain undefined. We hypothesize adrenomedullin (AM) plays a role in this process. Premenstrually progesterone levels decline, stimulating prostaglandi... Read More about The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair.

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming (2010)
Journal Article
Hansen, A., Henderson, S., Lagos, D., Nikitenko, L., Coulter, E., Roberts, S., …Boshoff, C. (2010). KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Genes & development, 24(2), 195-205. https://doi.org/10.1101/gad.553410

Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation of genes associated with blood vessel endothelial cells (BECs). Conseq... Read More about KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells (2007)
Journal Article
Vart, R. J., Nikitenko, L. L., Lagos, D., Trotter, M. W., Cannon, M., Bourboulia, D., …Boshoff, C. (2007). Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Research, 67(9), 4042-4051. https://doi.org/10.1158/0008-5472.CAN-06-3321

Kaposi's sarcoma (KS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiogen... Read More about Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.

Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density (2006)
Journal Article
Nikitenko, L. L., Cross, T., Campo, L., Turley, H., Leek, R., Manek, S., …Rees, M. C. (2006). Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density. Clinical cancer research : an official journal of the American Association for Cancer Research, 12(19), 5648-5658. https://doi.org/10.1158/1078-0432.CCR-06-0852

Purpose: The role for the hypoxia-inducible angiogenic factor adrenomedullin (AM) in tumor growth and progression has been suggested. Calcitonin receptor - like receptor (CL) is a G protein - coupled receptor (GPCR) that mediates effects of AM, but l... Read More about Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density.

Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism (2006)
Journal Article
Nikitenko, L. L., Blucher, N., Fox, S. B., Bicknell, R., Smith, D. M., & Rees, M. C. (2006). Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism. Journal of cell science, 119(5), 910-922. https://doi.org/10.1242/jcs.02783

Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotra... Read More about Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism.

Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2 (2005)
Journal Article
Carroll, V. A., Nikitenko, L. L., Bicknell, R., & Harris, A. L. (2005). Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 736-741. https://doi.org/10.1161/01.ATV.0000157980.15710.2b

Objective - The thrombolytic therapy drug, Reteplase, is a domain deletion mutant of tissue plasminogen activator (tPA), comprising the kringle 2 and protease (K2P) domains. Some kringle domains of hemostatic proteins are antiangiogenic and promote a... Read More about Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2.

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. (2003)
Journal Article
Nikitenko, L. L., Smith, D. M., Bicknell, R., & Rees, M. C. (2003). Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. FASEB Journal, 17(11), 1499-1501. https://doi.org/10.1096/fj.02-0993fje

Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of endothelial cell apoptosis, and promotion of angiogenesis. Recent... Read More about Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia..

Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus (2001)
Journal Article
Nikitenko, L. L., Brown, N. S., Smith, D. M., MacKenzie, I. Z., Bicknell, R., & Rees, M. C. (2001). Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus. Molecular Human Reproduction, 7(7), 655-664. https://doi.org/10.1093/molehr/7.7.655

The calcitonin receptor-like receptor (CRLR) can function as a receptor for either calcitonin gene-related peptide (CGRP) or adrenomedullin (AM), depending upon co-expression with members of a novel family of receptor activity-modifying proteins (RAM... Read More about Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus.

Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium (2000)
Journal Article
Nikitenko, L. L., MacKenzie, I. Z., Rees, M. C., & Bicknell, R. (2000). Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium. Molecular Human Reproduction, 6(9), 811-819. https://doi.org/10.1093/molehr/6.9.811

Human endometrium is a mucosa served by a microvascular blood supply that involves benign angiogenesis under the control of ovarian steroids throughout reproductive life. Adrenomedullin is a multifunctional 52-amino acid peptide involved in numerous... Read More about Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium.

Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens (2000)
Journal Article
Nikitenko, L. L., Lloyd, B. H., Rudland, P. S., Fear, S., & Barraclough, R. (2000). Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens. International journal of cancer. Journal international du cancer, 86(2), 219-228. https://doi.org/10.1002/%28SICI%291097-0215%2820000415%2986%3A2%3C219%3A%3AAID-IJC11%3E3.0.CO%3B2-7

Rodent S 100A4 (p9Ka) induces a metastatic phenotype in benign rat mammary tumour cells and cooperates with the neu oncogene to produce metastatic tumours in a transgenic mouse model system. Human S 100A4 possesses similar metastasis-inducing propert... Read More about Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens.

Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy (1998)
Journal Article
Nikitenko, L., Morgan, G., Kolesnikov, S. I., & Wooding, F. B. (1998). Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy. Journal of Histochemistry and Cytochemistry, 46(5), 679-688. https://doi.org/10.1177/002215549804600513

The fetus must transport considerable and increasing amounts of calcium across the placental trophoblast epithelium to support growth and development and bone formation. Active calcium transport across epithelia has been shown to correlate with calbi... Read More about Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy.