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Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis (2022)
Journal Article
Talbott, H. G., Wilkins, R. A., Redmond, A. C., Brockett, C. L., & Mengoni, M. (2022). The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis. Clinical biomechanics, 99, Article 105745. https://doi.org/10.1016/j.clinbiomech.2022.105745

Background: Subchondral bone cysts are a common presentation in ankle haemarthropathy. The relationship with ankle joint health has however not previously been investigated. The aim of this study was to assess the influence of subchondral bone cysts... Read More about The relationship between subchondral bone cysts and cartilage health in the Tibiotalar joint: A finite element analysis.

Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation? (2021)
Journal Article
Bates, K. T., Wang, L., Dempsey, M., Broyde, S., Fagan, M. J., & Cox, P. G. (2021). Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?. Interface, 18(180), Article 20210324. https://doi.org/10.1098/rsif.2021.0324

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluatio... Read More about Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?.

Morphological variation of the hemophilic talus (2021)
Journal Article
Talbott, H. G., Wilkins, R. A., Redmond, A. C., Brockett, C. L., & Mengoni, M. (2021). Morphological variation of the hemophilic talus. Clinical Anatomy, 34(6), 941-947. https://doi.org/10.1002/ca.23757

Flattening of the trochlear tali is clinically observed as structural and functional changes advance in patients with hemarthropathy of the ankle. However, the degree of this flattening has not yet been quantified, and distribution of the morphologic... Read More about Morphological variation of the hemophilic talus.

Evolutionary biomechanics: hard tissues and soft evidence? (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Evolutionary biomechanics: hard tissues and soft evidence?. Proceedings of the Royal Society B: Biological Sciences, 288(1945), Article 20202809. https://doi.org/10.1098/rspb.2020.2809

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record i... Read More about Evolutionary biomechanics: hard tissues and soft evidence?.

The biomechanical role of the chondrocranium and the material properties of cartilage (2020)
Journal Article
Jones, M. E. H., Gröning, F., Aspden, R. M., Dutel, H., Sharp, A., Moazen, M., …Evans, S. E. (2020). The biomechanical role of the chondrocranium and the material properties of cartilage. Vertebrate Zoology, 70(4), 699-715. https://doi.org/10.26049/VZ70-4-2020-10

The chondrocranium is the cartilage component of the vertebrate braincase. Among jawed vertebrates it varies greatly in structure, mineralisation, and in the extent to which it is replaced by bone during development. In mammals, birds, and some bony... Read More about The biomechanical role of the chondrocranium and the material properties of cartilage.

Viscoelastically active sutures – A stitch in time? (2020)
Journal Article
France, L. A., & Fancey, K. S. (2021). Viscoelastically active sutures – A stitch in time?. Materials Science and Engineering: C, 121, Article 111695. https://doi.org/10.1016/j.msec.2020.111695

We present results to show that a commercially available polypropylene suture filament (Ethicon Prolene), following annealing and tensile creep can, after creep load removal, release viscoelastically stored energy over a period of several weeks. Spec... Read More about Viscoelastically active sutures – A stitch in time?.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering (2020)
Journal Article
Jaganathan, S. K., & Mani, M. P. (in press). Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering. Journal of Industrial Textiles, Article 152808372090680. https://doi.org/10.1177/1528083720906809

In the recent decade, the growth of medical textiles is enormous and it paves the sustained development in the quality of life. In this research, an electrospun textile scaffold comprising polyurethane impregnated with Alternanthera sessilis oil was... Read More about Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.

Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn (2019)
Journal Article
Phillipps, S., Ali, S. S., Bremer, M. N., de Propris, R., Sansom, A. E., Cluver, M. E., …Wang, L. (2020). Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn. Monthly notices of the Royal Astronomical Society, 492(2), 2128-2139. https://doi.org/10.1093/mnras/stz3552

© 2019 The Author(s) We use data from the GAMA and GALEX surveys to demonstrate that the UV upturn, an unexpected excess of ultraviolet flux from a hot stellar component, seen in the spectra of many early-type galaxies, arises from processes internal... Read More about Galaxy and Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn.

An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein (2019)
Journal Article
Jothi, L., Jaganathan, S. K., & Nageswaran, G. (2020). An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein. Materials Chemistry and Physics, 242, Article 122514. https://doi.org/10.1016/j.matchemphys.2019.122514

In this work, a novel label-free electrochemical immunosensor for the detection of alpha-fetoprotein (AFP) is fabricated for early diagnosis and prognostics of liver cancer. A porous graphene nanoribbon (PGNR) was synthesized via chemical reduction m... Read More about An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein.

Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering (2019)
Journal Article
Mani, M. P., Jiang, H., Mani, M. P., & Jaganathan, S. K. (2019). Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering. International Journal of Nanomedicine, 14, 8149-8159. https://doi.org/10.2147/IJN.S214646

Introduction: Recently several new approaches were emerging in bone tissue engineering to develop a substitute for remodelling the damaged tissue. In order to resemble the native extracellular matrix (ECM) of the human tissue, the bone scaffolds must... Read More about Multifaceted characterization and in vitro assessment of polyurethane-based electrospun fibrous composite for bone tissue engineering.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More about Bite force and cranial bone strain in four species of lizards.

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), Article 11946. https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More about Validation of an algorithm to reveal the U wave in atrial fibrillation.

Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering (2018)
Journal Article
Qi, J., Zhang, H., Wang, Y., Mani, M. P., & Jaganathan, S. K. (2018). Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering. International Journal of Nanomedicine, 13, 2777-2788. https://doi.org/10.2147/IJN.S151242

Introduction: Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should... Read More about Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering.

Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons (2018)
Journal Article
Jothi, L., Neogi, S., Jaganathan, S. K., & Nageswaran, G. (2018). Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons. Biosensors & bioelectronics, 105, 236-242. https://doi.org/10.1016/j.bios.2018.01.040

© 2018 Elsevier B.V. A novel nitrogen/argon (N2/Ar) radio frequency (RF) plasma functionalized graphene nanosheet/graphene nanoribbon (GS/GNR) hybrid material (N2/Ar/GS/GNR) was developed for simultaneous determination of ascorbic acid (AA), dopamine... Read More about Simultaneous determination of ascorbic acid, dopamine and uric acid by a novel electrochemical sensor based on N2/Ar RF plasma assisted graphene nanosheets/graphene nanoribbons.

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), Article 20170637. https://doi.org/10.1098/rsif.2017.0637

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More about The biomechanical role of the chondrocranium and sutures in a lizard cranium.

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), Article 20161038. https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More about Form-function relationships in dragonfly mandibles under an evolutionary perspective.