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Mapping arginine methylation in the human body and cardiac disease (2016)
Journal Article
Onwuli, D. O., Rigau-Roca, L., Cawthorne, C., & Beltran-Alvarez, P. (2017). Mapping arginine methylation in the human body and cardiac disease. Proteomics. Clinical applications, 11(1-2), Article ARTN 1600106. https://doi.org/10.1002/prca.201600106

Purpose Arginine methylation (ArgMe) is one of the most ubiquitous post-translational modifications, and hundreds of proteins undergo ArgMe in e.g. brain. However, the scope of ArgMe in many tissues, including the heart, is currently under explored.... Read More about Mapping arginine methylation in the human body and cardiac disease.

Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers (2016)
Journal Article
Voulgari, E., Bakandritsos, A., Galtsidis, S., Zoumpourlis, V., Burke, B. P., Clemente, G. S., …Avgoustakis, K. (2016). Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers. Journal of controlled release : official journal of the Controlled Release Society, 243, 342-356. https://doi.org/10.1016/j.jconrel.2016.10.021

© 2016 Elsevier B.V. The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(me... Read More about Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers.

The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models (2016)
Journal Article
Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D., Cawthorne, C., Keen, H., …Brindle, K. M. (2016). The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research, 6(1), Article 63. https://doi.org/10.1186/s13550-016-0218-3

Background Recent studies have shown that 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentrations and whether they correla... Read More about The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., …Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.