cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway

Aburima, A.; Walladbegi, K.; Wake, J. D.; Naseem, K. M.

doi:10.1111/jth.13738

Nutrigenetics—Personalized Nutrition in the Genetic Age (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., & Lucock, M. (2017). Nutrigenetics—Personalized Nutrition in the Genetic Age. Exploratory research and hypothesis in medicine, 2(4), 109-116. https://doi.org/10.14218/ERHM.2017.00027

Diet is an important modifiable determinant of disease, and it is becoming clear that diet and genetic risk factors are interactive in determining risk for diseases such as cardiovascular disease, diabetes and cancers. Advances in technology have imp... Read More about Nutrigenetics—Personalized Nutrition in the Genetic Age.

ORAI channels are critical for receptor-mediated endocytosis of albumin (2017)
Journal Article
Zeng, B., Chen, G., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., …Xu, S. (2017). ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications, 8(1), Article 1920. https://doi.org/10.1038/s41467-017-02094-y

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PT... Read More about ORAI channels are critical for receptor-mediated endocytosis of albumin.

Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. (2017). Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagulation and Fibrinolysis, 28(8), 602-611. https://doi.org/10.1097/mbc.0000000000000644

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Calibrated automated thrombography (CAT) is emerging as a reliable tool for real-Time estimation of thrombin generation potential. There is a clinical need for knowledge about the pathways under... Read More about Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography.

Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma? (2017)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2017). Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?. European respiratory journal, 50(6), Article 1701366. https://doi.org/10.1183/13993003.01366-2017

Copyright © ERS 2017. Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncont... Read More about Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?.

Does FeNO Predict Clinical Characteristics in Chronic Cough? (2017)
Journal Article
Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. H. (2018). Does FeNO Predict Clinical Characteristics in Chronic Cough?. Lung, 196(1), 59-64. https://doi.org/10.1007/s00408-017-0074-6

© 2017, The Author(s). Purpose: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. Methods: We have studied consecutive patients attending a sp... Read More about Does FeNO Predict Clinical Characteristics in Chronic Cough?.

Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries (2017)
Journal Article
Higginson, I. J., Bennett, E., Daveson, B. A., Cooper, F., Morrison, R. S., Yi, D., …Wei, G. (2017). Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries. BMC Geriatrics, 17(1), https://doi.org/10.1186/s12877-017-0648-4

© 2017 The Author(s). Background: Achieving choice is proposed as a quality marker. But little is known about what influences preferences especially among older adults. We aimed to determine and compare, across three countries, factors associated wit... Read More about Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries.

Frequency of folate-related polymorphisms varies by skin pigmentation (2017)
Journal Article
Jones, P., Lucock, M., Veysey, M., Jablonski, N., Chaplin, G., & Beckett, E. (2018). Frequency of folate-related polymorphisms varies by skin pigmentation. American Journal of Human Biology, 30(2), Article e23079. https://doi.org/10.1002/ajhb.23079

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of genetic variance and environmental exposures. Evidence suggests folate l... Read More about Frequency of folate-related polymorphisms varies by skin pigmentation.

Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study (2017)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study. Scientific reports, 7(1), Article ARTN 15366. https://doi.org/10.1038/s41598-017-15402-9

© 2017 The Author(s). Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementa... Read More about Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study.

InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome (2017)
Journal Article
Thota, R. N., Abbott, K. A., Ferguson, J. J. A., Veysey, M., Lucock, M., Niblett, S., …Garg, M. L. (2017). InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-15460-z

© 2017 The Author(s). The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participa... Read More about InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome.

Is swimming safe in heart failure? : a systematic review (2017)
Journal Article
Shah, P. M., Pellicori, P., Macnamara, A., Urbinati, A., & Clark, A. L. (2017). Is swimming safe in heart failure? : a systematic review. Cardiology in review, 25(6), 321-325. https://doi.org/10.1097/CRD.0000000000000154

It is not clear whether swimming is safe in patients with chronic heart failure. Ten studies examining the hemodynamic effects of acute water immersion (WI) (155 patients; average age 60 years; 86% male; mean left ventricular ejection fraction (LVEF)... Read More about Is swimming safe in heart failure? : a systematic review.

The Role of Chemokines in Thyroid Carcinoma (2017)
Journal Article
Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process... Read More about The Role of Chemokines in Thyroid Carcinoma.

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials (2017)
Journal Article
Cleland, J. G., Bunting, K. V., Flather, M., Altman, D. G., Holmes, J., Coats, A. J., …Beta-blockers in Heart Failure Collaborative Group. (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39(1), 26-35. https://doi.org/10.1093/eurheartj/ehx564

Aims: Recent guidelines recommend that patients with heart failure and left ventricular ejection fraction (LVEF) 40-49% should be managed similar to LVEF ≥50%. We investigated the effect of beta-blockers according to LVEF in double-blind, randomised,... Read More about Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials.

Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain (2017)
Journal Article
Talley, N., Holtmann, G., Nguyen, Q., Gibson, P., Bampton, P., Veysey, M., …Jones, M. (2017). Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain. Journal of Gastroenterology and Hepatology, 32(11), 1813-1817. https://doi.org/10.1111/jgh.13791

© 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe... Read More about Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain.

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy (2017)
Journal Article
Cheah, R., Srivastava, R., Stafford, N. D., Beavis, A. W., Green, V., & Greenman, J. (2017). Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy. International Journal of Oncology, 51(4), 1227-1238. https://doi.org/10.3892/ijo.2017.4118

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be impr... Read More about Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy.

Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome (2017)
Journal Article
Bauersachs, S., Simintiras, C. A., Sturmey, R. G., Krebs, S., Bick, J., Blum, H., …Forde, N. (2017). Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome. Biology of Reproduction, 97(3), 413-425. https://doi.org/10.1093/biolre/iox095

The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on Day 19 of pregnancy. Imm... Read More about Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study (2017)
Journal Article
Walsh, S. L., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., …Wells, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. European respiratory journal, 50(2), Article 1700936. https://doi.org/10.1183/13993003.00936-2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts p... Read More about Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study.

Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study (2017)
Journal Article
Walabyeki, J., Adamson, J., Buckley, H. L., Sinclair, H., Atkin, K., Graham, H., …Macleod, U. (2017). Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study. PLoS ONE, 12(8), e0183647. https://doi.org/10.1371/journal.pone.0183647

Background Presenting to primary care with potential cancer symptoms is contingent on one’s ability to recognize potentially serious symptoms. We investigated differences between smokers and non-smokers in symptoms experienced, awareness and consulti... Read More about Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study.

“Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program (2017)
Journal Article
Harwood, A., Broadbent, E., Totty, J. P., Smith, G. E., & Chetter, I. C. (2017). “Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program. Journal of Vascular Nursing, 35(3), 131-135. https://doi.org/10.1016/j.jvn.2017.03.001

© 2017 Society for Vascular Nursing, Inc. Intermittent claudication (IC) is a common condition which has severe impacts on quality of life, physical function, and mental health. Supervised exercise is the recommended first-line treatment for patients... Read More about “Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program.

Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. A. (2017). Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro. Blood Coagulation and Fibrinolysis, 28(5), 365-372. https://doi.org/10.1097/MBC.0000000000000607

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Microvesicles associated with tissue factor (TF) may play a role in cancer-related venous thromboembolism; however, not much is known about their interaction with the tumour stroma, es... Read More about Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro.

cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738

Essentials Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction. We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change. NO inhibits shape change, RhoA/ROCK signalling a... Read More about cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.

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