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What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review. (2019)
Journal Article
Dell Olio, M., Pask, S., Seymour, J., & Reeve, J. (2019). What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review. European journal for person centered healthcare, 7(4), https://doi.org/10.5750/ejpch.v7i4.1779

Introduction Growing numbers of people now live with long term conditions. For each person, the challenges are multiple and unique to that individual. In recognition of this, health policy places greater emphasis on the delivery of person-centred ca... Read More about What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review..

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., …Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease (2019)
Journal Article
Turner, A., Chijoff, E., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2019). Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease. Journal of Nutrition and Intermediary Metabolism, 18, 100106. https://doi.org/10.1016/j.jnim.2019.100106

Incidence rates of inflammatory bowel disease (IBD) are increasing worldwide. This correlates with increased consumption of red meats, alcohol, refined sugars, oils and animal fats, typical of a “Western” diet. Poor dietary habits are the most ubiqui... Read More about Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease.

Micronutrients and bioactive compounds in oral inflammatory diseases (2019)
Journal Article
Kaur, K., Sculley, D., Wallace, J., Turner, A., Ferraris, C., Veysey, M., …Beckett, E. L. (2019). Micronutrients and bioactive compounds in oral inflammatory diseases. Journal of Nutrition and Intermediary Metabolism, 18, Article 100105. https://doi.org/10.1016/j.jnim.2019.100105

Oral disorders are a significant public health concern. Oral inflammatory diseases are periodontal infections, oral mucosal lesions, pulpal and periapical lesions. The aetiology is multi-factorial and usually associated with a microbial origin, often... Read More about Micronutrients and bioactive compounds in oral inflammatory diseases.

Biochemical and immunocytochemical characterization of coronins in platelets (2019)
Journal Article
Riley, D. R., Khalil, J. S., Naseem, K. M., & Rivero, F. (in press). Biochemical and immunocytochemical characterization of coronins in platelets. Platelets, 1-12. https://doi.org/10.1080/09537104.2019.1696457

Results Platelets express at least four coronins Proteomics and transcriptomics studies indicate that both human and mouse platelets express Coro1, 2, 3 and 7, while other coronins are practically undetectable (Supplemental Table 1 and 2). To demonst... Read More about Biochemical and immunocytochemical characterization of coronins in platelets.

Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme (2019)
Journal Article
Vince, R. V., Kirk, R. J., Aye, M. M., Atkin, S. L., & Madden, L. A. (2020). Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme. Cell Stress and Chaperones, 25(1), 73-80. https://doi.org/10.1007/s12192-019-01048-1

Induction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible hea... Read More about Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., …Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial (2019)
Journal Article
Northgraves, M. J., Arunachalam, L., Madden, L. A., Marshall, P., Hartley, J. E., MacFie, J., & Vince, R. V. (2019). Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-019-05098-0

© 2019, The Author(s). Background and objectives: To investigate the feasibility of delivering a functional exercise-based prehabilitation intervention and its effects on postoperative length of hospital stay, preoperative physical functioning and he... Read More about Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial.

Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model? (2019)
Journal Article
Olubajo, F., Achawal, S., & Greenman, J. (2020). Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model?. Translational Oncology, 13(1), 1-10. https://doi.org/10.1016/j.tranon.2019.09.002

© 2019 The Authors BACKGROUND: One way to overcome the genetic and molecular variations within glioblastoma is to treat each tumour on an individual basis. To facilitate this, we have developed a microfluidic culture paradigm that maintains human gli... Read More about Development of a Microfluidic Culture Paradigm for Ex Vivo Maintenance of Human Glioblastoma Tissue: A New Glioblastoma Model?.

Folate and Inflammation – links between folate and features of inflammatory conditions (2019)
Journal Article
Jones, P., Lucock, M., Scarlett, C. J., Veysey, M., & Beckett, E. L. (2019). Folate and Inflammation – links between folate and features of inflammatory conditions. Journal of Nutrition and Intermediary Metabolism, 18, Article 100104. https://doi.org/10.1016/j.jnim.2019.100104

Folate serves as a cofactor for one-carbon (1C) transfer reactions. These reactions are involved in the synthesis of DNA nucleotides, the amino acid methionine, and in the regulation of homocysteine (Hcy) levels. Emerging evidence suggests that these... Read More about Folate and Inflammation – links between folate and features of inflammatory conditions.

Expression of microRNA in follicular fluid in women with and without PCOS (2019)
Journal Article
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., …Atkin, S. L. (2019). Expression of microRNA in follicular fluid in women with and without PCOS. Scientific reports, 9(1), Article 16306. https://doi.org/10.1038/s41598-019-52856-5

© 2019, The Author(s). Several studies have shown the expression of small non-coding microRNA (miRNA) changes in PCOS and their expression in follicular fluid has been described, though the number of studies remains small. In this prospective cohort... Read More about Expression of microRNA in follicular fluid in women with and without PCOS.

Optimising platelet secretomes to deliver robust tissue-specific regeneration (2019)
Journal Article
Scully, D., Sfyri, P., Wilkinson, H. N., Acebes‐Huerta, A., Verpoorten, S., Muñoz‐Turrillas, M. C., …Matsakas, A. (2020). Optimising platelet secretomes to deliver robust tissue-specific regeneration. Journal of tissue engineering and regenerative medicine, 14(1), 82-98. https://doi.org/10.1002/term.2965

Promoting cell proliferation is the cornerstone of most tissue regeneration therapies. As platelet-based applications promote cell division and can be customised for tissue-specific efficacy, this makes them strong candidates for developing novel reg... Read More about Optimising platelet secretomes to deliver robust tissue-specific regeneration.

Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis (2019)
Journal Article
Verpoorten, S., Sfyri, P., Scully, D., Mitchell, R., Tzimou, A., Mougios, V., …Matsakas, A. (2020). Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis. Acta Physiologica, 228(3), https://doi.org/10.1111/apha.13395

Aim: The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Since skeletal muscle regenerative capacity is regulated by satellite cells, we aimed to investigate whet... Read More about Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis.

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility (2019)
Journal Article
Farmer, L., Rollason, R., Whitcomb, D., Ni, L., Goodlif, A., Lay, A., …Welsh, G. (2019). TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Journal of the American Society of Nephrology : JASN, 30(10), 1910-1924. https://doi.org/10.1681/ASN.2018070729

BACKGROUND: Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other pathologic phenotype, suggesti... Read More about TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.

Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (2019)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Harwood, A. E., Ingle, L., Huang, C., & Chetter, I. C. (2019). Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. The Cochrane database of systematic reviews, 2019(9), Article CD013407. https://doi.org/10.1002/14651858.cd013407

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of prehabilitation (preoperative exercise, either alone or in combination with nutritional or psychological interventions or both)... Read More about Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease.

Family display, family type, or community? Limitations in the application of a concept (2019)
Journal Article
Walsh, J., McNamee, S., & Seymour, J. (2019). Family display, family type, or community? Limitations in the application of a concept. Families, Relationships and Societies, https://doi.org/10.1332/204674319x15647592551202

In this paper we develop the concept of family display by responding to David Morgan’s suggestion that researchers should consider whether ‘family displays’ are used to convey a ‘type’ of Family. We do so by applying the concept to the accounts of mi... Read More about Family display, family type, or community? Limitations in the application of a concept.

Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22 (2019)
Journal Article
Wilkinson, H. N., Roberts, E. R., Stafford, A. R., Banyard, K. L., Matteucci, P., Mace, K. A., & Hardman, M. J. (2019). Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22. American Journal of Pathology, 189(11), 2196-2208. https://doi.org/10.1016/j.ajpath.2019.07.015

Macrophages are important for effective iron recycling and erythropoiesis, but they also play a crucial role in wound healing, orchestrating tissue repair. Recently, we demonstrated a significant accumulation of iron in healing wounds and a requireme... Read More about Tissue iron promotes wound repair via M2 macrophage polarisation and the chemokines CCL17 and CCL22.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study (2019)
Journal Article
Buture, A., Boland, J. W., Ahmed, F., & Dikomitis, L. (2019). Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study. Journal of Multidisciplinary Healthcare, 12, 691-698. https://doi.org/10.2147/JMDH.S207128

Introduction and objective: The diagnosis of primary headaches is based on the International Classification of Headache Disorders (ICHD-3). Cluster headache (CH), a debilitating primary headache, is often misdiagnosed as migraine. In the absence of b... Read More about Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study.

Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence (2019)
Journal Article
Nickolay, T., Nichols, S., Ingle, L., & Hoye, A. (2020). Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence. Current Cardiology Reviews, 16(3), 212-220. https://doi.org/10.2174/1573403X15666190819144336

Coronary collateral vessels supply blood to areas of myocardium at risk after arterial occlusion. Flow through these channels is driven by a pressure gradient between the donor and the occluded artery. Concomitant with increased collateral flow is an... Read More about Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence.