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All Outputs (53)

Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: To evaluate if the use of micro-ultrasound (microUS) can detect significant prostate (csPCa) pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having prostate cancer, who h... Read More about Evaluating the Role of Ultrasound in Prostate cancer (ERUP) trial – Phase 1 early experience of micro-ultrasound in the UK.

High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., …Twiddy, M. (2024). High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study. Annals of vascular surgery, 102, Article 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Introduction A novel high-intensity interval training (HIIT) programme has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT programme to inform refinemen... Read More about High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): a qualitative acceptability study.

How can patients influence service improvement decision-making? A participatory research mixed methods study (2023)
Journal Article
Drinkwater, J., MacFarlane, A., Twiddy, M., Meads, D., Chadwick, R. H., Donnelly, A., …Foy, R. (in press). How can patients influence service improvement decision-making? A participatory research mixed methods study. The British journal of general practice : the journal of the Royal College of General Practitioners, Article BJGP-2023-0263.R2. https://doi.org/10.3399/BJGP.2023.0263

Background Health policy promotes patient participation in decision-making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the... Read More about How can patients influence service improvement decision-making? A participatory research mixed methods study.

Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study (2023)
Journal Article
Akwa, L. G., Smith, L., Twiddy, M., Abt, G., Garnett, C., Oldham, M., …Herbec, A. (2023). Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study. PLoS ONE, 18(10 October), Article e0287199. https://doi.org/10.1371/journal.pone.0287199

Introduction The COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity we... Read More about Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study.

High-intensity interval training in patients with intermittent claudication (2023)
Journal Article
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., …Chetter, I. C. (2023). High-intensity interval training in patients with intermittent claudication. Journal of vascular surgery, 78(4), 1048-1056.e4. https://doi.org/10.1016/j.jvs.2023.05.045

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation (2023)
Journal Article
Gordon, H., Hebenton, J., Davie-Smith, F., Twiddy, M., Smith, G., & Carradice, D. (2023). Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation. Journal of Vascular Societies Great Britain and Ireland, 2(4), 208-214. https://doi.org/10.54522/jvsgbi.2023.081

Background: Through knee amputation (TKA) may offer benefits over above knee amputation (AKA) in patients unsuitable for below knee amputation. This retrospective analysis compared surgical and rehabilitation outcomes post TKA and AKA. Methods: Al... Read More about Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation.

Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales (2023)
Journal Article
Thiery, H., Cook, J., Burchell, J., Wilberforce, M., Twiddy, M., Nikolova, S., …Hulme, C. (2023). Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales. Social Sciences & Humanities Open, 8(1), Article 100714. https://doi.org/10.1016/j.ssaho.2023.100714

Adult Social Care (ASC) in England faces an ‘existential crisis’, caught between increased demand for services and continued cuts to social care and local government budgets. Increasingly, it is argued that this crisis cannot be solved without reform... Read More about Transforming adult social care systems? A systematic review of the costs and outcomes of local area coordination in England and Wales.

Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review (2022)
Journal Article
Hitchman, L., Totty, J., Smith, G. E., Carradice, D., Twiddy, M., Iglesias, C., …Chetter, I. C. (2022). Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review. International wound journal, https://doi.org/10.1111/iwj.14035

Emerging evidence suggests that extracorporeal shockwave therapy (ESWT) may improve time to DFU healing. The aim of this review was to appraise the evidence on role of ESWT in DFU healing and impact of different ESWT doses. Databases were searched fo... Read More about Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review.

Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives (2022)
Journal Article
Twiddy, M., Birtwistle, J., Edmondson, A., Croft, J., Gordon, K., Meads, D., …Harji, D. (2022). Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives. BJS Open, 6(6), Article zrac137. https://doi.org/10.1093/bjsopen/zrac137

Background: Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients' and clinicians' perspectives associated with the conduct of an RCT comp... Read More about Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives.

Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study (2022)
Journal Article
Twiddy, M., Trump, B., & Ramsden, S. (2022). Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study. PLoS ONE, 17(9), Article e0274890. https://doi.org/10.1371/journal.pone.0274890

As the effects of climate change become more visible, extreme weather events are becoming more common. The effects of flooding on health are understood but the long-term impact on the well-being of those affected need to be considered. This mixed met... Read More about Understanding the long-term impact of flooding on the wellbeing of residents: A mixed methods study.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2022)
Journal Article
Pearson, M., Jackson, G., Jackson, C., Boland, J., Featherstone, I., Huang, C., …Johnson, M. (2022). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. BMJ open, 12(7), Article e060450. https://doi.org/10.1136/bmjopen-2021-060450

INTRODUCTION: Delirium is a complex condition in which altered mental state and cognition causes severe distress and poor clinical outcomes for patients and families, anxiety and stress for the health professionals and support staff providing care, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations. The Cochrane database of systematic reviews, 2021(12), CD013839. https://doi.org/10.1002/14651858.CD013839.pub2

BACKGROUND: Diabetes and vascular disease are the leading causes of lower limb amputation. Currently, 463 million adults are living with diabetes, and 202 million with peripheral vascular disease, worldwide. When a lower limb amputation is considered... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience (2021)
Journal Article
Chen, H., Twiddy, M., Jones, L., & Johnson, M. J. (2021). The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience. European Journal of Cancer Care, 30(6), Article e13503. https://doi.org/10.1111/ecc.13503

Objective: The objective of this study is to explore the specific information and communication needs of men affected by prostate cancer to inform the development of educational materials for clinicians. Methods: This is a qualitative descriptive stu... Read More about The unique information and communication needs of men affected by prostate cancer: A qualitative study of men's experience.

A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol (2021)
Journal Article
Twiddy, M., Hazara, A., Bhandari, S., & Allgar, V. (in press). A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-021-02072-1

Background: Incremental haemodialysis/haemodiafiltration (HD) may help reduce early mortality rates in patients starting HD. This mixed-method feasibility study aims to test the acceptability, tolerance and safety of a novel incremental HD regime, an... Read More about A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol.

The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review (2021)
Journal Article
Simms, M., Parker, P., Rigby, A., Whybrow, P., & Twiddy, M. (in press). The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review. Ultrasound, https://doi.org/10.1177/1742271X21995212

Background: The use of multiparametric magnetic resonance imaging (mpMRI) within active surveillance of prostate cancer programmes is identified by the UK National Institute for Health and Care Excellence (NICE guideline NG 131 2019) as having a role... Read More about The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review.

The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres (2021)
Journal Article
Burton, W., Sahota, P., Twiddy, M., Brown, J., & Bryant, M. (in press). The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres. Prevention Science, https://doi.org/10.1007/s11121-021-01205-y

Background Poor participant engagement threatens the potential impact and cost effectiveness of public health programmes preventing meaningful evaluation and wider application. Although barriers and levers to engagement with public health programmes... Read More about The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres.

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (2021)
Journal Article
Brown, J. M., Croft, J., Poad, H., Bell, R., Collinson, M., Gordon, K., …Goodwin, L. (2021). Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study. Journal of Clinical Oncology, 39(3), 202-214. https://doi.org/10.1200/JCO.20.01665

PURPOSE: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial co... Read More about Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.