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Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials (2010)
Journal Article
Shahin, Y., Mazari, F., & Chetter, I. (2011). Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials. International journal of surgery, 9(3), 209-213. https://doi.org/10.1016/j.ijsu.2010.12.006

Background Several studies have reported the clinical effects of long-term treatment with cardioprotective medications in patients with lower limb peripheral arterial disease (PAD) in terms of reducing cardiovascular morbidity and mortality. A numbe... Read More about Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials.

Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? (2010)
Journal Article
Agarwal, V., Lind, M. J., & Cawkwell, L. (2011). Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?. Cancer Treatment Reviews, 37(7), 533-542. https://doi.org/10.1016/j.ctrv.2010.11.004

The median survival for patients with malignant pleural mesothelioma remains extremely poor and there is a need for the development of more effective treatment modalities. The epidermal growth factor receptor is frequently over-expressed in malignant... Read More about Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?.

The national heart failure audit for England and Wales 2008-2009 (2010)
Journal Article
Yassin, A., Cleland, J., McDonagh, T., Rigby, A. S., Whittaker, T., Dargie, H. J., & on behalf of the National Heart Failure Audit Team for England and Wales. (2011). The national heart failure audit for England and Wales 2008-2009. Heart, 97(11), 876-886. https://doi.org/10.1136/hrt.2010.209171

Objectives To obtain national data on the clinical characteristics, investigation, management and outcome of patients hospitalised with a diagnosis of heart failure. Method A survey was carried out of the first 10 patients hospitalised with a primary... Read More about The national heart failure audit for England and Wales 2008-2009.

Cough hypersensitivity syndrome: A distinct clinical entity (2010)
Journal Article
Morice, A. H., Faruqi, S., Wright, C. E., Thompson, R., & Bland, J. M. (2011). Cough hypersensitivity syndrome: A distinct clinical entity. Lung, 189(1), 73-79. https://doi.org/10.1007/s00408-010-9272-1

We postulate that most patients with chronic cough have a single discrete clinical entity: Cough Hypersensitivity Syndrome. We constructed a questionnaire that elicits the major components of the syndrome. Here we describe the validation of this ques... Read More about Cough hypersensitivity syndrome: A distinct clinical entity.

Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance (2010)
Journal Article
Smith, G. E., Samuel, N., Wolstenholme, S., Akomolafe, A. B., & Chetter, I. C. (2010). Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance. Ultrasound, 18(4), 186-190. https://doi.org/10.1258/ult.2010.010035

Inflammatory abdominal aortic aneurysms (IAAAs) account for 3-10% of all abdominal aortic aneurysms and are characterized by a thickened aneurysmal wall, with extensive fibrosis and adhesions. Ultrasound remains the investigation of choice for diagno... Read More about Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance.

Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics (2010)
Journal Article
Maslekar, S., Gardiner, A. B., Monson, J. R. T., & Duthie, G. S. (2010). Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics. Colorectal Disease, 12(12), 1254-1259. https://doi.org/10.1111/j.1463-1318.2009.02005.x

Aim Artificial neural networks (ANNs) are computer programs used to identify complex relations within data. Routine predictions of presence of colorectal pathology based on population statistics have little meaning for individual patient. This result... Read More about Artificial neural networks to predict presence of significant pathology in patients presenting to routine colorectal clinics.

Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy (2010)
Journal Article
Murray, A., Little, S. J., Stanley, P., Cawkwell, L., & Maraveyas, A. (2010). Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy. Oncology Reports, 24(4), 1049-1058. https://doi.org/10.3892/or-00000954

Angiogenesis inhibitors may enhance the effects of low dose (metronomic) chemotherapy. However, there is a wide range of novel angiogenesis inhibitors which must be tested in combinations with oral chemotherapy agents to assess the anti-endothelial a... Read More about Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao (2010)
Journal Article
Rahman, M. A., Khan, J. A., Mazari, F. A. K., Mockford, K., McCollum, P. T., & Chetter, I. (2011). A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao. Annals of vascular surgery, 25(1), 32-38. https://doi.org/10.1016/j.avsg.2010.06.006

BackgroundA double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (A... Read More about A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication (2010)
Journal Article
Mockford, K. A., Mazari, F. A. K., Jordan, A. R., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2011). Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. Annals of vascular surgery, 25(2), 182-190. https://doi.org/10.1016/j.avsg.2010.07.021

One-third of all elderly patients fall each year and impaired balance has been recognized as a specific risk factor. Intermittent claudication is common among the elderly population, affecting approximately 5% of the population over the age of 50. Th... Read More about Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., …Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

The role of blood pressure variability in the development of nephropathy in type 1 diabetes (2010)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2010). The role of blood pressure variability in the development of nephropathy in type 1 diabetes. Diabetes Care, 33(11), 2442-2447. https://doi.org/10.2337/dc10-1000

OBJECTIVE - Increases in blood pressure and visit-to-visit variability have both been found to independently increase the likelihood of cardiovascular events in nondiabetic individuals. This study has investigated whether each may also influence the... Read More about The role of blood pressure variability in the development of nephropathy in type 1 diabetes.

Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity (2010)
Journal Article
Carradice, D., Mazari, F. A., Mekako, A., Hatfield, J., Allgar, V., & Chetter, I. (2010). Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 40(3), 393-398. https://doi.org/10.1016/j.ejvs.2010.04.010

Aim: The durability of occlusion post endovenous laser therapy (EVLT) for varicose veins is linked to the magnitude of energy delivered to the vein and consequently increasing amounts of energy are employed. The aim of this study is to establish whet... Read More about Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity.

A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study (2010)
Journal Article
Barton, R., English, A., Nabb, S., Rigby, A. S., & Johnson, M. J. (2010). A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study. Lung Cancer, 70(3), 313-319. https://doi.org/10.1016/j.lungcan.2010.03.007

Background: Breathlessness remains a refractory symptom in malignant lung disease. Breathing training is an effective, non-pharmacological intervention but it is unclear how this should be delivered. This feasibility study aimed to assess recruitment... Read More about A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study.

Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status (2010)
Journal Article
Hodgkinson, V. C., Eagle, G. L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2010). Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status. Cancer Letters, 294(1), 13-24. https://doi.org/10.1016/j.canlet.2010.01.036

This review describes and discusses the advantages and limitations of proteomic approaches in the identification of biomarkers associated with chemotherapy resistance. Both gel-based (two-dimensional polyacrylamide gel electrophoresis) and gel-free (... Read More about Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status.