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All Outputs (4)

Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects (2014)
Journal Article
Hu, L., Zhu, J., Rotchell, J. M., Wu, L., Gao, J., & Shi, H. (2015). Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects. The Science of the total environment, 508, 258-265. https://doi.org/10.1016/j.scitotenv.2014.11.086

The frog embryo teratogenesis assay-Xenopus (FETAX) is an established method for the evaluation of the developmental toxicities of chemicals. To develop an enhanced FETAX that is appropriate for common environmental contaminants, we exposed Xenopus t... Read More about Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects.

Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens (2014)
Journal Article
Lerebours, A., Stentiford, G., Bignell, J. P., Lyons, B. P., Derocles, S. A. P., & Rotchell, J. (2014). Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens. Environmental Science and Technology, 48(17), 10448-10455. https://doi.org/10.1021/es502591p

Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point of historical exposure to stressors. Liver cancer has been used to monitor the effects of exposure to anthropogenic pollution in flatfish for many ye... Read More about Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens.

Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos (2014)
Journal Article
Zhu, J., Shi, H., Zhu, P., Hu, L., Wu, L., Yang, Y., & Rotchell, J. M. (2014). Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos. Environmental Toxicology and Pharmacology, 38(1), 153-162. https://doi.org/10.1016/j.etap.2014.05.010

We exposed Xenopus tropicalis embryos to a selective antagonist of retinoid X receptor (UVI3003). UVI3003 induced multiple malformations at the concentrations of 200-1000. μg/L after 48. h exposure. The most prominent malformations affected brains, e... Read More about Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.

Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France) (2014)
Journal Article
Gerbron, M., Geraudie, P., Fernandes, D., Rotchell, J. M., Porte, C., & Minier, C. (2014). Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France). Environmental pollution, 191, 58-62. https://doi.org/10.1016/j.envpol.2014.04.015

A large variety of anthropogenic chemicals present in the aquatic environment have been shown to be able to alter the endocrine system of exposed organisms, potentially impacting their reproductive function. The aim of this study was to assess the ef... Read More about Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France).