All Outputs (36)

Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis (2016)
Journal Article
Faruqi, S., Shiferaw, D., & Morice, A. H. (2016). Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis. Open Respiratory Medicine Journal, 10, 105-108. https://doi.org/10.2174/1874306401610010105

© Faruqi et al. Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves sympto... Read More about Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis.

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., …Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More about Influence of case definition on incidence and outcome of acute coronary syndromes.

Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise (2016)
Journal Article
Goodall, S., Thomas, K., Barwood, M., Keane, K., Gonzalez, J. T., St Clair Gibson, A., & Howatson, G. (2017). Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise. Acta Physiologica, 220(4), 486-500. https://doi.org/10.1111/apha.12844

Introduction An initial bout of eccentric exercise is known to protect against muscle damage following a repeated bout of the same exercise; however, the neuromuscular adaptations owing to this phenomenon are unknown. Aim To determine whether ne... Read More about Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise.

Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index (2016)
Journal Article
Duvivier, R., & Veysey, M. (2016). Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index. Medical Education, 50(12), 1245-1248. https://doi.org/10.1111/medu.13091

© 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education Current tools for clinical assessment are tedious and time-consuming, particularly the dreadful long case. There is a need for novel instruments that incorporate ot... Read More about Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index.

Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis (2016)
Journal Article
Khreis, H., Kelly, C., Tate, J., Parslow, R., Lucas, K., & Nieuwenhuijsen, M. (2017). Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis. Environment International, 100, 1-31. https://doi.org/10.1016/j.envint.2016.11.012

Background and objective The question of whether children's exposure to traffic-related air pollution (TRAP) contributes to their development of asthma is unresolved. We conducted a systematic review and performed meta-analyses to analyze the associa... Read More about Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis.

STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma (2016)
Journal Article
Morton, R. W., Elphick, H. E., Rigby, A. S., Daw, W. J., King, D. A., Smith, L. J., & Everard, M. L. (2017). STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma. Thorax, 72(4), 347-354. https://doi.org/10.1136/thoraxjnl-2015-208171

Background Suboptimal adherence to inhaled steroids is common in children with asthma and is associated with poor disease control, reduced quality of life and even death. Previous studies using feedback of electronically monitored adherence data have... Read More about STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma.

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin (2016)
Journal Article
Williamson, J. D., Sadofsky, L. R., Crooks, M. G., Greenman, J., & Hart, S. P. (2016). Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Experimental Lung Research, 42(8-10), 397-407. https://doi.org/10.1080/01902148.2016.1243742

© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms unde... Read More about Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., …Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes (2016)
Journal Article
Lucock, M., Beckett, E., Martin, C., Jones, P., Furst, J., Yates, Z., …Veysey, M. (2017). UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes. American Journal of Human Biology, 29(2), Article e22929. https://doi.org/10.1002/ajhb.22929

© 2016 Wiley Periodicals, Inc. Objectives: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin p... Read More about UV-associated decline in systemic folate: implications for human nutrigenetics, health, and evolutionary processes.

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More about The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise.

Internet-based training of coronary artery patients: the Heart Cycle Trial (2016)
Journal Article
Skobel, E., Knackstedt, C., Martinez-Romero, A., Salvi, D., Vera-Munoz, C., Napp, A., …Cleland, J. (2017). Internet-based training of coronary artery patients: the Heart Cycle Trial. Heart and vessels, 32(4), 408-418. https://doi.org/10.1007/s00380-016-0897-8

© 2016, Springer Japan. Low adherence to cardiac rehabilitation (CR) might be improved by remote monitoring systems that can be used to motivate and supervise patients and tailor CR safely and effectively to their needs. The main objective of this st... Read More about Internet-based training of coronary artery patients: the Heart Cycle Trial.

Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation (2016)
Journal Article
Forde, N., Maillo, V., O'Gaora, P., Simintiras, C. A., Sturmey, R. G., Ealy, A. D., …Lonergan, P. (2016). Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation. Biology of Reproduction, 95(4), Article ARTN 92. https://doi.org/10.1095/biolreprod.116.139857

In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inact... Read More about Sexually dimorphic gene expression in bovine conceptuses at the initiation of implantation.

Factors of resilience in informal caregivers of people with dementia from integrative international data analysis (2016)
Journal Article
Joling, K. J., Windle, G., Dröes, R., Meiland, F., van Hout, H. P., MacNeil Vroomen, J., …Woods, B. (2016). Factors of resilience in informal caregivers of people with dementia from integrative international data analysis. Dementia and Geriatric Cognitive Disorders, 42(3-4), 198-214. https://doi.org/10.1159/000449131

Background/Aims: Although caring for a person with dementia can be stressful, some caregivers appear to experience few negative consequences to their well-being. This study aimed to examine what proportion of caregivers demonstrates resilience under... Read More about Factors of resilience in informal caregivers of people with dementia from integrative international data analysis.

Impact of antipsychotic review and non‐pharmacological intervention on health‐related quality of life in people with dementia living in care homes: WHELD—a factorial cluster randomised controlled trial (2016)
Journal Article
Ballard, C., Orrell, M., Sun, Y., Moniz-Cook, E., Stafford, J., Whitaker, R., …Fossey, J. (2017). Impact of antipsychotic review and non‐pharmacological intervention on health‐related quality of life in people with dementia living in care homes: WHELD—a factorial cluster randomised controlled trial. International journal of geriatric psychiatry, 32(10), 1094-1103. https://doi.org/10.1002/gps.4572

Background: Very few interventional studies have directly examined the impact of treatment approaches on Health-Related Quality of Life (HRQL) in people with dementia. This is of particular importance in therapies to address behavioural symptoms, whe... Read More about Impact of antipsychotic review and non‐pharmacological intervention on health‐related quality of life in people with dementia living in care homes: WHELD—a factorial cluster randomised controlled trial.

Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial (2016)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The second... Read More about Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., …Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.

Chemotherapy treatment of multiple myeloma patients increases circulating levels of endothelial microvesicles (2016)
Journal Article
Gardiner, E., Madden, L., Maraveyas, A., Adesanya, M. A., Hall, J., & Sayala, H. (2016). Chemotherapy treatment of multiple myeloma patients increases circulating levels of endothelial microvesicles. Thrombosis Research, 146, 20-22. https://doi.org/10.1016/j.thromres.2016.08.017

Correspondence

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells (2016)
Journal Article
Sinclair, A., Park, L., Shah, M., Drotar, M., Calaminus, S., Hopcroft, L. E., …Holyoake, T. L. (2016). CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), 371-383. https://doi.org/10.1182/blood-2015-08-661785

The regulation of hematopoietic stem cell (HSC) survival and self-renewal within the bone marrow (BM) niche is not well understood. We therefore investigated global transcriptomic profiling of normal human HSC/hematopoietic progenitor cells [HPCs], r... Read More about CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Cerebral Regulation in Different Maximal Aerobic Exercise Modes (2016)
Journal Article
Pires, F. O., dos Anjos, C. A. S., Covolan, R. J. M., Pinheiro, F. A., St Clair Gibson, A., Noakes, T. D., …Ugrinowitsch, C. (in press). Cerebral Regulation in Different Maximal Aerobic Exercise Modes. Frontiers in Physiology, 7, Article 253. https://doi.org/10.3389/fphys.2016.00253

We investigated cerebral responses, simultaneously with peripheral and ratings of perceived exertion (RPE) responses, during different VO2MAX-matched aerobic exercise modes. Nine cyclists (VO2MAX of 57.5 ± 6.2 ml·kg−1·min−1) performed a maximal, cont... Read More about Cerebral Regulation in Different Maximal Aerobic Exercise Modes.