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The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy (2017)
Journal Article
Clark, A. L., Hoye, A., Beddoes, G., Nikolaidou, T., & Brown, O. I. (2018). The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy. IEEE transactions on bio-medical engineering / Bio-medical Engineering Group, 65(8), 1711-1716. https://doi.org/10.1109/TBME.2017.2769060

Goal: The HF-CGM is a proof-of-principle study to investigate whether cardiogoniometry (CGM), a three-dimensional electrocardiographic method, can differentiate between pacing modes in patients with cardiac resynchronization therapy (CRT). Methods: A... Read More about The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy.

Is swimming safe in heart failure? : a systematic review (2017)
Journal Article
Shah, P. M., Pellicori, P., Macnamara, A., Urbinati, A., & Clark, A. L. (2017). Is swimming safe in heart failure? : a systematic review. Cardiology in review, 25(6), 321-325. https://doi.org/10.1097/CRD.0000000000000154

It is not clear whether swimming is safe in patients with chronic heart failure. Ten studies examining the hemodynamic effects of acute water immersion (WI) (155 patients; average age 60 years; 86% male; mean left ventricular ejection fraction (LVEF)... Read More about Is swimming safe in heart failure? : a systematic review.

Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure (2017)
Journal Article
Nikolaidou, T., Pellicori, P., Zhang, J., Kazmi, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2018). Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure. Clinical Research in Cardiology, 107(2), 108-119. https://doi.org/10.1007/s00392-017-1162-6

© 2017 The Author(s) Aims: To determine the prevalence, incidence, predictors, and prognostic implications of PR interval prolongation in patients referred with suspected heart failure. Methods and results: Consecutive patients referred with suspecte... Read More about Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure.

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency (2017)
Journal Article
Gonzalez, S., Windram, J. D., Sathyapalan, T., Javed, Z., Clark, A., & Atkin, S. L. (2017). Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency. Journal of International Medical Research, 45(6), 1708-1719. https://doi.org/10.1177/0300060517723798

Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followe... Read More about Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency.

Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation? (2017)
Journal Article
Nichols, S., Gleadall-Siddall, D. O., Antony, R., Clark, A. L., Cleland, J. G. F., Carroll, S., & Ingle, L. (2018). Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?. Clinical physiology and functional imaging, 38(4), 681-688. https://doi.org/10.1111/cpf.12468

Summary Objective Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equiva... Read More about Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?.

Heart failure - what's new and what's changed? (2017)
Journal Article
Callan, P. D., & Clark, A. L. (2017). Heart failure - what's new and what's changed?. Clinical Medicine, 16(Suppl_6), s37-s42. https://doi.org/10.7861/clinmedicine.16-6-s37

Physicians responsible for the care of patients with heart failure due to left ventricular systolic dysfunction have access to a broad range of evidence-based treatments that prolong life and reduce symptoms. In spite of the significant progress made... Read More about Heart failure - what's new and what's changed?.

In-hospital worsening heart failure: a clinically relevant endpoint? (2017)
Journal Article
Clark, A. L., Cherif, M., McDonagh, T. A., & Squire, I. B. (2018). In-hospital worsening heart failure: a clinically relevant endpoint?. ESC Heart Failure, 5(1), 9-18. https://doi.org/10.1002/ehf2.12195

Outcome measures used for the clinical evaluation of patients with acute heart failure differ between studies and may neither adequately address the characteristic presenting symptoms and signs nor reflect the pathophysiological processes involved. I... Read More about In-hospital worsening heart failure: a clinically relevant endpoint?.

Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure (2017)
Journal Article
Fröhlich, H., Torres, L., Täger, T., Schellberg, D., Corletto, A., Kazmi, S., …Frankenstein, L. (2017). Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure. Clinical Research in Cardiology, 106(9), 711-721. https://doi.org/10.1007/s00392-017-1115-0

© 2017, Springer-Verlag Berlin Heidelberg. Aims: Beta-blockers are recommended for the treatment of chronic heart failure (CHF). However, it is disputed whether beta-blockers exert a class effect or whether there are differences in efficacy between a... Read More about Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure.

This patient is not breathing properly: is this COPD, heart failure, or neither? (2017)
Journal Article
Pellicori, P., Salekin, D., Pan, D., & Clark, A. L. (2017). This patient is not breathing properly: is this COPD, heart failure, or neither?. Expert Review of Cardiovascular Therapy, 15(5), 389-396. https://doi.org/10.1080/14779072.2017.1317592

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are two common, heterogeneous, long-term illnesses which cause significant morbidity and mortality. Alth... Read More about This patient is not breathing properly: is this COPD, heart failure, or neither?.

Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study (2017)
Journal Article
Pellicori, P., Clark, A. L., Kallvikbacka-Bennett, A., Zhang, J., Urbinati, A., Monzo, L., …Cleland, J. G. (2017). Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study. European journal of heart failure, 19(7), 883-892. https://doi.org/10.1002/ejhf.825

Background: Jugular venous distension, reflecting raised right atrial pressure (RAP), is a classical sign of congestive heart failure (CHF), but its clinical assessment can be difficult. Methods: RAP was measured non-invasively using near-infrared sp... Read More about Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study.

The effects of short-term omission of daily medication on the pathophysiology of heart failure (2017)
Journal Article
Dovancescu, S., Pellicori, P., Mabote, T., Torabi, A., Clark, A. L., & Cleland, J. G. (2017). The effects of short-term omission of daily medication on the pathophysiology of heart failure. European journal of heart failure, 19(5), 643-649. https://doi.org/10.1002/ejhf.748

Aims Pharmacological therapies for heart failure (HF) aim to improve congestion, symptoms, and prognosis. Failing to take medication is a potential cause of worsening HF. Characterizing the effects of short-term medication omission could inform the d... Read More about The effects of short-term omission of daily medication on the pathophysiology of heart failure.

Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure (2017)
Journal Article
Fröhlich, H., Raman, N., Täger, T., Schellberg, D., Goode, K. M., Kazmi, S., …Frankenstein, L. (2017). Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure. International journal of cardiology, 238, 97-104. https://doi.org/10.1016/j.ijcard.2017.03.028

© 2017 Elsevier B.V. Background In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival – while statin usage is not. The impact of statin treatment on the “reverse epidemiology”... Read More about Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure.

What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan? (2017)
Journal Article
Pellicori, P., Urbinati, A., Shah, P., MacNamara, A., Kazmi, S., Dierckx, R., …Clark, A. L. (2017). What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?. European journal of heart failure, 19(6), 768-778. https://doi.org/10.1002/ejhf.788

Aims The PARADIGM-HF trial showed that sacubitril–valsartan, an ARB–neprilysin inhibitor, is more effective than enalapril for some patients with heart failure (HF). It is uncertain what proportion of patients with HF would be eligible for sacubitril... Read More about What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?.

Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction (2017)
Journal Article
Sze, S., Zhang, J., Pellicori, P., Morgan, D., Hoye, A., & Clark, A. L. (2017). Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction. Clinical Research in Cardiology, 106(7), 533-541. https://doi.org/10.1007/s00392-017-1082-5

© 2017, Springer-Verlag Berlin Heidelberg. Background: Frailty and malnutrition are common in patients with heart failure (HF), and are associated with adverse outcomes. We studied the prognostic value of three malnutrition and three frailty indices... Read More about Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction.

Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling (2017)
Journal Article
Zhang, J., Wong, K., Clark, A. L., & Cleland, J. G. (2017). Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling. International journal of cardiology, 233, 67-72. https://doi.org/10.1016/j.ijcard.2017.01.127

Background The relation between changes in NT-proBNP and renal function has commonly been studied using multiple regressions, which may ignore the complexity of relations between related variables. Methods and results Data were collected from patient... Read More about Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling.