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All Outputs (128)

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (2023)
Journal Article
Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. (2023). Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Cancer Research, 83(16_Supplement), B001-B001. https://doi.org/10.1158/1538-7445.kidney23-b001

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive cancer. In the UK, there are around 9000 diagnoses and 3000 deaths annually. Targeted therapies that inhibit angiogenic regulators, such as bevac... Read More about Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Journal Article
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.

Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. (2023)
Journal Article
Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., …Maraveyas, A. (2023). Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Pancreatology, 23(4), e7-e8. https://doi.org/10.1016/j.pan.2023.04.025

In our EARLY DIAgnosis of PAncreatic Cancer (EARLY DIAPAC) study, we aim to analyse molecular changes or “signatures” associated with early stages of pancreatic carcinogenesis by using the combination of: (i) Label-Free Quantitative Proteomics (LFQP)... Read More about Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer..

Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer (2023)
Journal Article
Adekeye, A., Haque, F., Ettelaie, C., Nikitenko, L., & Maraveyas, A. (2023). Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer. Cancer Research, 83(7_Supplement), 224-224. https://doi.org/10.1158/1538-7445.am2023-224

Background: Pancreatic cancer (PC) is a leading cause of cancer-related deaths globally. Accurate PC detection at early or premalignant stage, when surgery is effective, would increase survival rates and prevent unnecessary surgery or surveillance. A... Read More about Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer.

A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers (2021)
Journal Article
Hitchman, L., Totty, J., Lathan, R., Sidapra, M., Smith, G., Carradice, D., & Chetter, I. (2021). A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers. British journal of surgery, 108(supp.6), Article 1031. https://doi.org/10.1093/bjs/znab259.1127

Aim The purpose of this mixed methods feasibility study was to assess the feasibility of delivering ESWT to patients with DFUs. It also aimed to explore any potential clinical effect of ESWT on wound healing and investigate whether ESWT may offer an... Read More about A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers.

An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. (2020)
Journal Article
Isaac, E., Cooper, S., Lancaster, M., Loubani, M., & Jones, S. (2020). An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart. Circulation Research, 127(Suppl_1), A493

Background: Nav1.5 is the predominantly expressed voltage-gated sodium channel (VGSC) isoform in the heart, responsible for phase 0 of the action potential. Our rodent studies have shown expression of neuronal isoform Nav1.8 protein in the adult hear... Read More about An age-associated reduction in Nav1.5 protein expression correlates with an increase in Nav1.8 protein expression in the right atrial appendage of the human heart..

Advance care planning: exploration of the public’s understanding. In Abstracts from the 11th EAPC World Research Congress Online, 7th – 9th October 2020 (2020)
Journal Article
Mcllfatrick, S., Hasson, F., Slater, P., Beck, E., McCloskey, S., Carr, K., …Hanna-Trainor, L. (2020). Advance care planning: exploration of the public’s understanding. In Abstracts from the 11th EAPC World Research Congress Online, 7th – 9th October 2020. Palliative medicine, 34(1_suppl), https://doi.org/10.1177/0269216320958098

Background/aims: Advance care planning, a voluntary process whereby an individual outline their preferences and beliefs, to aid in planning for end of life care, is widely considered an essential step for achieving a `good death”. Raising awareness o... Read More about Advance care planning: exploration of the public’s understanding. In Abstracts from the 11th EAPC World Research Congress Online, 7th – 9th October 2020.

Impact of WHELD intervention on neuropsychiatric symptoms, antipsychotic use and quality of life in people with dementia living in nursing homes: a cluster- randomized trial (2017)
Journal Article
Crawford, F., Ballard, C., Fossey, J., Corbett, A., Orrell, M., Romeo, R., …Whitaker, R. (2017). Impact of WHELD intervention on neuropsychiatric symptoms, antipsychotic use and quality of life in people with dementia living in nursing homes: a cluster- randomized trial. Alzheimer's & dementia, 13(7, supplement), 171. https://doi.org/10.1016/j.jalz.2017.07.011

Long-term outcomes of a randomized clinical trial of supervised exercise, percutaneous transluminal angioplasty or combined treatment for patients with intermittent claudication due to femoropopliteal disease (2017)
Journal Article
Mazari, F. A., Khan, J. A., Samuel, N., Smith, G., Carradice, D., McCollum, P., & Chetter, I. (2017). Long-term outcomes of a randomized clinical trial of supervised exercise, percutaneous transluminal angioplasty or combined treatment for patients with intermittent claudication due to femoropopliteal disease. Journal of vascular surgery, 65(4), 1239-1240. https://doi.org/10.1016/j.jvs.2017.02.014

Background: To compare the long-term outcomes of angioplasty (PTA), supervised exercise (SEP) and combined treatment (PTA+SEP) in patients with intermittent claudication (IC) due to femoropopliteal disease. Methods: Patients recruited to PTA, SEP and... Read More about Long-term outcomes of a randomized clinical trial of supervised exercise, percutaneous transluminal angioplasty or combined treatment for patients with intermittent claudication due to femoropopliteal disease.