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All Outputs (60)

National comparative audit of red blood cell transfusion practice in hospices: Recommendations for palliative care practice (2018)
Journal Article
Neoh, K., Gray, R., Grant-Casey, J., Estcourt, L., Malia, C., Boland, J. W., & Bennett, M. I. (2019). National comparative audit of red blood cell transfusion practice in hospices: Recommendations for palliative care practice. Palliative medicine, 33(1), 102-108. https://doi.org/10.1177/0269216318801755

Background: Red blood cell transfusions are commonly used in palliative care to treat anaemia or symptoms caused by anaemia. In patients with advanced disease, there is little evidence of benefit to guide treatment decisions in the face of increased... Read More about National comparative audit of red blood cell transfusion practice in hospices: Recommendations for palliative care practice.

In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits (2018)
Journal Article
Boland, J. W., Johnson, M., Ferreira, D., & Berry, D. J. (2018). In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits. Palliative medicine, 32(7), 1222-1232. https://doi.org/10.1177/0269216318773956

Background: Morphine can cause central nervous system side effects which impair driving skills. The legal blood morphine concentration limit for driving is 20 µg/L in France/Poland/Netherlands and 80 µg/L in England/Wales. There is no guidance as to... Read More about In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits.

The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review (2018)
Journal Article
Ferreira, D. H., Boland, J. W., Phillips, J. L., Lam, L., & Currow, D. C. (2018). The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review. Palliative medicine, 32(4), 786-803. https://doi.org/10.1177/0269216317746583

Background: Driving cessation is associated with poor health-related outcomes. People with chronic diseases are often prescribed long-term opioid agonists that have the potential to impair driving. Studies evaluating the impact of opioids on driving-... Read More about The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review.

Psychometric validation of the needs assessment tool: Progressive disease in interstitial lung disease (2017)
Journal Article
Johnson, M. J., Jamali, A., Ross, J., Fairhurst, C., Boland, J., Reigada, C., …Yorke, J. (2018). Psychometric validation of the needs assessment tool: Progressive disease in interstitial lung disease. Thorax, 73(9), 880-883. https://doi.org/10.1136/thoraxjnl-2017-210911

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. The inter-rater/test-retest reliability and construct validity... Read More about Psychometric validation of the needs assessment tool: Progressive disease in interstitial lung disease.

Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting (2017)
Journal Article
Digges, M., Hussein, A., Wilcock, A., Crawford, G. B., Boland, J. W., Agar, M. R., …Johnson, M. J. (2018). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting. Journal of palliative medicine, 21(1), 37-43. https://doi.org/10.1089/jpm.2017.0159

Background Haloperidol is widely prescribed as an anti-emetic in patients receiving palliative care, but there is limited evidence to support and refine its use. Objective To explore the immediate and short-term net clinical effects of haloperidol wh... Read More about Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting.

Influence of opioids on immune function in patients with cancer pain: from bench to bedside (2017)
Journal Article
Boland, J. W., & Pockley, A. G. (in press). Influence of opioids on immune function in patients with cancer pain: from bench to bedside. British Journal of Pharmacology, 175(14), 2726-2736. https://doi.org/10.1111/bph.13903

In patients with cancer, opioids are principally used for the management of acute surgical and chronic cancer-related pain. However, opioids have many non-analgesic effects, including direct and indirect effects on cancer cells and on anti-tumour imm... Read More about Influence of opioids on immune function in patients with cancer pain: from bench to bedside.

Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis (2017)
Journal Article
Boland, J. W., Allgar, V., Boland, E. G., Oviasu, O., Agar, M., Currow, D. C., & Johnson, M. J. (2017). Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis. Journal of palliative medicine, 20(11), 1274-1279. https://doi.org/10.1089/jpm.2017.0129

Background: Medications for symptom management in palliative care have associated, but poorly understood, harms. Drug-related harms have important clinical implications, may impact on patients’ compliance and contribute to symptoms. Objective: To exp... Read More about Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis.

Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review (2016)
Journal Article
Obita, G. P., Boland, E. G., Currow, D. C., Johnson, M. J., & Boland, J. W. (2016). Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. Journal of pain and symptom management, 52(6), 901-919. https://doi.org/10.1016/j.jpainsymman.2016.05.032

Context Somatostatin analogues are commonly used to relieve symptoms in malignant bowel obstruction (MBO) but are more expensive than other antisecretory agents. Objectives To evaluate the evidence of effectiveness of somatostatin analogues compared... Read More about Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review.

Clinically relevant concentrations of opioids for in vitro studies (2016)
Journal Article
Boland, J. W., & Pockley, A. G. (2016). Clinically relevant concentrations of opioids for in vitro studies. Journal of Opioid Management, 12(5), 313-321. https://doi.org/10.5055/jom.2016.0348

© 2016 Journal of Opioid Management, All Rights Reserved. Objectives: Numerous in vitro studies have evaluated the influence of opioids on many biological and immunological processes. The concentrations that have been used in these studies span a lar... Read More about Clinically relevant concentrations of opioids for in vitro studies.

Medical students writing on death, dying and palliative care : a qualitative analysis of reflective essays (2016)
Journal Article
Boland, J. W., Dikomitis, L., & Gadoud, A. (2016). Medical students writing on death, dying and palliative care : a qualitative analysis of reflective essays. BMJ supportive & palliative care, 6(4), 486-492. https://doi.org/10.1136/bmjspcare-2016-001110

Background: Medical students and doctors are becoming better prepared to care for patients with palliative care needs and support patients at the end of life. This preparation needs to start at medical school. Objective: To assess how medical student... Read More about Medical students writing on death, dying and palliative care : a qualitative analysis of reflective essays.

Communication and support from health-care professionals to families, with dependent children, following the diagnosis of parental life-limiting illness : a systematic review (2016)
Journal Article
Fearnley, R., & Boland, J. W. (2017). Communication and support from health-care professionals to families, with dependent children, following the diagnosis of parental life-limiting illness : a systematic review. Palliative medicine, 31(3), 212-222. https://doi.org/10.1177/0269216316655736

Background: Communication between parents and their children about parental life-limiting illness is stressful. Parents want support from health-care professionals; however, the extent of this support is not known. Awareness of family’s needs would h... Read More about Communication and support from health-care professionals to families, with dependent children, following the diagnosis of parental life-limiting illness : a systematic review.

The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease (2016)
Journal Article
Boland, J. W., Reigada, C., Yorke, J., Hart, S. P., Bajwah, S., Ross, J., …Johnson, M. J. (2016). The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease. Journal of palliative medicine, 19(5), 549-555. https://doi.org/10.1089/jpm.2015.0355

Background: Irrreversible interstitial lung disease (ILD) is associated with high morbidity and mortality. Palliative care needs of patients and caregivers are not routinely assessed; there is no tool to identify needs and triage support in clinical... Read More about The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease.

Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review (2015)
Journal Article
Boland, J. W., Ziegler, L., Boland, E. G., McDermid, K., & Bennett, M. I. (2015). Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review. Pain, 156(11), 2152-2163. https://doi.org/10.1097/j.pain.0000000000000306

© 2015 International Association for the Study of Pain. Opioids are important in the management of pain in patients with cancer. Clinicians and patients are sometimes concerned about the effect of opioids on survival, which might decrease opioid pres... Read More about Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review.

A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research (2015)
Journal Article
Boland, J., Currow, D. C., Wilcock, A., Tieman, J., Hussain, J. A., Pitsillides, C., …Johnson, M. J. (2015). A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research. Journal of pain and symptom management, 49(4), 762-772. https://doi.org/10.1016/j.jpainsymman.2014.09.018

© 2015 American Academy of Hospice and Palliative Medicine. Context The challenges of palliative care clinical trial recruitment are well documented. Objectives The aim of the study was to review tested strategies to improve recruitment to trials of... Read More about A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research.

Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review (2014)
Journal Article
Boland, J. W., McWilliams, K., Ahmedzai, S. H., & Pockley, A. G. (2014). Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review. The British Journal of Cancer, 111(5), 866-873. https://doi.org/10.1038/bjc.2014.384

Background: The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management o... Read More about Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review.

A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function (2013)
Journal Article
Boland, J. W., Foulds, G. A., Ahmedzai, S. H., & Graham Pockley, A. (2014). A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function. BMJ supportive & palliative care, 4(4), 357-367. https://doi.org/10.1136/bmjspcare-2013-000573

Background: Studies have demonstrated that whereas some opioids have little effect on immunity (eg, buprenorphine), others can be immunosuppressive (eg, morphine) or immunostimulatory (eg, tramadol). However, a variety of approaches have been used, e... Read More about A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function.

Palliative care for people with non-malignant lung disease: summary of current evidence and future direction (2013)
Journal Article
Boland, J., Martin, J., & Wells, A. U. (2013). Palliative care for people with non-malignant lung disease: summary of current evidence and future direction. Palliative medicine, 27(9), 811-816. https://doi.org/10.1177/0269216313493467

Background: The physical and psychosocial needs of patients with chronic non-malignant lung disease are comparable to those with lung cancer. This article will focus on chronic obstructive pulmonary disease, interstitial lung disease and cystic fibro... Read More about Palliative care for people with non-malignant lung disease: summary of current evidence and future direction.

End-of-life care for non-cancer patients (2013)
Journal Article
Boland, J., & Johnson, M. J. (2013). End-of-life care for non-cancer patients. BMJ supportive & palliative care, 3(1), 2-3. https://doi.org/10.1136/bmjspcare-2013-000446

[Extract]: The origins and early development of palliative care focussed on patients with cancer, apart from sporadic developments in a few non-malignant diseases such as MND and HIV. In the UK, this has been compounded by the setting of palliative c... Read More about End-of-life care for non-cancer patients.

Developing a service for patients with very severe chronic obstructive pulmonary disease (COPD) within resources (2013)
Journal Article
Boland, J., Owen, J., Ainscough, R., & Mahdi, H. (2014). Developing a service for patients with very severe chronic obstructive pulmonary disease (COPD) within resources. BMJ supportive & palliative care, 4(2), 196-201. https://doi.org/10.1136/bmjspcare-2012-000393

Chronic obstructive pulmonary disease (COPD) is a common life-limiting illness with significant burden for patient and carer. Despite this, access to supportive and specialist palliative care is inconsistent and implementation of published good pract... Read More about Developing a service for patients with very severe chronic obstructive pulmonary disease (COPD) within resources.