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Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device (2021)
Journal Article
Richardson, S., Iles, A., Rotchell, J. M., Charlson, T., Hanson, A., Lorch, M., & Pamme, N. (2021). Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device. PLoS ONE, 16(12), Article e0260102. https://doi.org/10.1371/journal.pone.0260102

Contamination of waterways is of increasing concern, with recent studies demonstrating elevated levels of antibiotics, antidepressants, household, agricultural and industrial chemicals in freshwater systems. Thus, there is a growing demand for method... Read More about Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device.

The influence of solvent representation on nuclear shielding calculations of protonation states of small biological molecules (2018)
Journal Article
Roggatz, C. C., Lorch, M., & Benoit, D. M. (2018). The influence of solvent representation on nuclear shielding calculations of protonation states of small biological molecules. Journal of chemical theory and computation : JCTC, 14(5), 2684-2695. https://doi.org/10.1021/acs.jctc.7b01020

In this study, we assess the influence of solvation on the accuracy and reliability of isotropic nuclear magnetic shielding calculations for amino acids in comparison to experimental data. We focus particularly on the performance of solvation methods... Read More about The influence of solvent representation on nuclear shielding calculations of protonation states of small biological molecules.

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules (2016)
Journal Article
Roggatz, C. C., Lorch, M., Hardege, J. D., & Benoit, D. M. (2016). Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules. Global change biology, 22(12), 3914-3926. https://doi.org/10.1111/gcb.13354

Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century. Effects of the change in ocean carbon chemistry and pH on the development, growt... Read More about Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules.

Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer (2016)
Journal Article
De Poli, M., Zawodny, W., Quinonero, O., Lorch, M., Webb, S. J., & Clayden, J. (2016). Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer. Science, 352(6285), 575-580. https://doi.org/10.1126/science.aad8352

The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution.We report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid b... Read More about Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer.

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions (2015)
Journal Article
Burke, B. P., Baghdadi, N., Kownacka, A. E., Nigam, S., Clemente, G. S., Al-Yassiry, M. M., …Archibald, S. J. (2015). Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. Nanoscale, 7(36), 14889-14896. https://doi.org/10.1039/c5nr02753e

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describ... Read More about Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions.

Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach (2013)
Journal Article
Cheng, F., Lorch, M., Sajedin, S. M., Kelly, S. M., & Kornherr, A. (2013). Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach. ChemSusChem, 6(8), 1392-1399. https://doi.org/10.1002/cssc.201300305

To inhibit the photocatalytic degradation of organic material supports induced by small titania (TiO2) nanoparticles, four kinds of TiO2 nanoparticles, that is, commercial P25-TiO2, commercial rutile phase TiO2, rutile TiO2 nanorods and rutile TiO2 s... Read More about Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach.

Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking (2013)
Journal Article
Diego-Taboada, A., Maillet, L., Banoub, J. H., Lorch, M., Rigby, A. S., Boa, A. N., …Mackenzie, G. (2013). Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking. Journal of Materials Chemistry B, 1(5), 707-713. https://doi.org/10.1039/c2tb00228k

Sporopollenin exine capsules (SEC) extracted from Lycopodium clavatum spores were shown to encapsulate ibuprofen as a drug model, with 97 ± 1% efficiency as measured by recovery of the loaded drug and absence of the drug on the SEC surface by scannin... Read More about Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking.

Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores (2012)
Journal Article
Diego-Taboada, A., Cousson, P., Raynaud, E., Huang, Y., Lorch, M., Binks, B., …Mackenzie, G. (2012). Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores. Journal of Materials Chemistry, 22(19), 9767-9773. https://doi.org/10.1039/c2jm00103a

Microcapsules were obtained conveniently from Lycopodium clavatum spores possessing either a single layered shell of sporopollenin (exine) or double layered shell of sporopollenin and cellulose with an inner layer (intine). These microcapsules were f... Read More about Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores.

Dynamic nuclear polarization-enhanced solid-state NMR of a 13C-labeled signal peptide bound to lipid-reconstituted sec translocon (2011)
Journal Article
Reggie, L., Lopez, J. J., Collinson, I., Glaubitz, C., & Lorch, M. (2011). Dynamic nuclear polarization-enhanced solid-state NMR of a 13C-labeled signal peptide bound to lipid-reconstituted sec translocon. Journal of the American Chemical Society, 133(47), 19084-19086. https://doi.org/10.1021/ja209378h

Dynamic nuclear polarization (DNP) has made it possible to record 2D double-quantum-filtered (DQF) solid-state NMR (ssNMR) spectra of a signal peptide bound to a lipid-reconstituted SecYEG translocon complex. The small quantity of peptide in the sampl... Read More about Dynamic nuclear polarization-enhanced solid-state NMR of a 13C-labeled signal peptide bound to lipid-reconstituted sec translocon.

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Hardege, J. D., Bartels-Hardege, H. D., Fletcher, N., Terschak, J. A., Harley, M., Smith, M. A., …Bublitz, R. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. https://doi.org/10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More about Identification of a female sex pheromone in Carcinus maenas.

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers (2010)
Journal Article
Batchelor, R., Windle, C. J., Buchoux, S., & Lorch, M. (2010). Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers. Journal of Biological Chemistry, 285(53), 41402-41411. https://doi.org/10.1074/jbc.M110.155176

Solid state NMR techniques have been used to investigate the effect that two serotonin receptor 1a agonists (quipazine and LY-165,163) have on the phase behavior of, and interactions within, cholesterol/phosphocholine lipid bilayers. The presence of... Read More about Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers.

Access to a primary aminosporopollenin solid support from plant spores (2010)
Journal Article
Barrier, S., Löbbert, A., Boasman, A. J., Boa, A. N., Lorch, M., Atkin, S. L., & MacKenzie, G. (2010). Access to a primary aminosporopollenin solid support from plant spores. Green chemistry : an international journal and green chemistry resource : GC, 12(2), 234-240. https://doi.org/10.1039/b913215e

Sporopollenin, which is a naturally occurring and highly resilient organic polymer constituting the external shell of spores and pollen grains, has been converted into a primary amine form with a loading of 0.58 +/- 0.04 mmol. g(-1) by reductive amin... Read More about Access to a primary aminosporopollenin solid support from plant spores.

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More about MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Phosphatidylglycerol lipids enhance folding of an α helical membrane protein (2008)
Journal Article
Seddon, A. M., Lorch, M., Ces, O., Templer, R. H., Macrae, F., & Booth, P. J. (2008). Phosphatidylglycerol lipids enhance folding of an α helical membrane protein. Journal of Molecular Biology, 380(3), 548-556. https://doi.org/10.1016/j.jmb.2008.05.001

Membrane lipids are increasingly being recognised as active participants in biological events. The precise roles that individual lipids or global properties of the lipid bilayer play in the folding of membrane proteins remain to be elucidated, Here,... Read More about Phosphatidylglycerol lipids enhance folding of an α helical membrane protein.

Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes (2008)
Journal Article
Lorch, M., & Lopez, J. J. (2008). Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes. Journal of Biological Chemistry, 283(12), 7813-7822. https://doi.org/10.1074/jbc.M707480200

Magic angle spinning (MAS) NMR has been used to investigate the location and orientation of five serotonin receptor 1a agonists (serotonin, buspirone, quipazine, 8-OH-DPAT, and LY-163,165) in single component model lipid and brain lipid membranes. Th... Read More about Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes.

Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR (2007)
Journal Article
Pfleger, N., Lorch, M., Woerner, A. C., Shastri, S., & Glaubitz, C. (2008). Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR. Journal of Biomolecular NMR, 40(1), 15-21. https://doi.org/10.1007/s10858-007-9203-5

The proteorhodopsin family consists of hundreds of homologous retinal containing membrane proteins found in bacteria in the photic zone of the oceans. They are colour tuned to their environment and act as light-driven proton pumps with a potential en... Read More about Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR.

Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence (2007)
Journal Article
Basting, D., Lorch, M., Lehner, I., & Glaubitz, C. (2008). Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence. FASEB Journal, 22(2), 365-373. https://doi.org/10.1096/fj.07-9162com

Efflux pumps of the small multidrug resistance family bind cationic, lipophilic antibiotics and transport them across the membrane in exchange for protons. The transport cycle must involve various conformational states of the protein needed for subst... Read More about Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence.