All Outputs (37)

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice (2014)
Journal Article
Taylor, R., Bullen, A., Johnson, S. L., Grimm-Günter, E. M., Rivero, F., Marcotti, W., …Daudet, N. (2015). Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice. Human molecular genetics, 24(1), 37-49. https://doi.org/10.1093/hmg/ddu417

© The Author 2014. Published by Oxford University Press. All rights reserved. Hearing relies on the mechanosensory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of their actin-rich stereociliary bundles... Read More about Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.

Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain (2014)
Journal Article
Lutz, J., Grimm-Günter, E. M. S., Joshi, P., & Rivero, F. (2014). Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Histochemistry and cell biology, 142(5), 511-528. https://doi.org/10.1007/s00418-014-1235-9

RhoBTB3 is an atypical member of the Rho family of small GTPases. It localizes at the Golgi apparatus and endosomes and is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. Previous studies using Northern bl... Read More about Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin (2013)
Journal Article
Swaminathan, K., Müller-Taubenberger, A., Faix, J., Rivero, F., & Noegel, A. A. (2014). A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. Proceedings of the National Academy of Sciences of the United States of America, 111(1), E25-E33. https://doi.org/10.1073/pnas.1315368111

The Cdc42- and Rac-interactive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac. Mutation of the Cdc42- and Rac-interactive binding motif abrogates Rac binding. This results in increased 1evels of activated Ra... Read More about A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.

An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis (2013)
Journal Article
Chung, C. Y., Feoktistov, A., Hollingsworth, R. J., Rivero, F., & Mandel, N. S. (2013). An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis. Biochemical and biophysical research communications, 436(4), 719-724. https://doi.org/10.1016/j.bbrc.2013.06.022

The WASP family of proteins has emerged as important regulators that connect multiple signaling pathways to regulate the actin cytoskeleton. Dictyostelium cells express WASP, as well as a WASP related protein, WASP-B, endoded by wasB gene. WASP-B con... Read More about An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.

GxcC connects Rap and Rac signaling during Dictyostelium development (2013)
Journal Article
Plak, K., Veltman, D., Fusetti, F., Beeksma, J., Rivero, F., Van Haastert, P. J., & Kortholt, A. (2013). GxcC connects Rap and Rac signaling during Dictyostelium development. BMC cell biology, 14(1), Article 6. https://doi.org/10.1186/1471-2121-14-6

Background: Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces pseudopod formation by acti... Read More about GxcC connects Rap and Rac signaling during Dictyostelium development.

MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein (2012)
Journal Article
Schenková, K., Lutz, J., Kopp, M., Ramos, S., & Rivero, F. (2012). MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Journal of Molecular Biology, 422(5), 659-673. https://doi.org/10.1016/j.jmb.2012.06.016

RhoBTB (BTB stands for broad-complex, tramtrack, bric à brac) proteins are tumor suppressors involved in the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes. However, no substrates of RhoBTB-Cul3 ubiquitin ligase complexes have been... Read More about MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium (2012)
Journal Article
Pakes, N. K., Veltman, D. M., Rivero, F., Nasir, J., Insall, R., & Williams, R. S. (2012). The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. Journal of cell science, 125(10), 2457-2465. https://doi.org/10.1242/jcs.100966

Dock (dedicator of cytokinesis) proteins represent a family of guanine nucleotide exchange factors (GEFs) that include the well-studied Dock180 family and the poorly characterised zizimin family. Our current understanding of Dock180 function is that... Read More about The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium.

Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells (2012)
Journal Article
Sultana, H., Neelakanta, G., Rivero, F., Blau-Wasser, R., Schleicher, M., & Noegel, A. A. (2012). Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells. BMC developmental biology, 12, Article 3. https://doi.org/10.1186/1471-213X-12-3

Background: Cell adhesion, an integral part of D. discoideum development, is important for morphogenesis and regulated gene expression in the multicellular context and is required to trigger cell-differentiation. G-protein linked adenylyl cyclase pat... Read More about Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells.

Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum (2011)
Journal Article
Sucgang, R., Kuo, A., Tian, X., Salerno, W., Parikh, A., Feasley, C. L., …Grigoriev, I. V. (2011). Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biology, 12(2), Article R20. https://doi.org/10.1186/gb-2011-12-2-r20

Background: The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk cells. There are four groups of... Read More about Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins (2011)
Journal Article
Revenu, C., Ubelmann, F., Hurbain, I., El-Marjou, F., Dingli, F., Loew, D., …Robine, S. (2012). A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Molecular Biology of the Cell, 23(2), 324-336. https://doi.org/10.1091/mbc.E11-09-0765

Actin-bundling proteins are identified as key players in the morphogenesis of thin membrane protrusions. Until now, functional redundancy among the actin-bundling proteins villin, espin, and plastin-1 has prevented definitive conclusions regarding th... Read More about A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication (2011)
Journal Article
Heidel, A. J., Lawal, H. M., Felder, M., Schilde, C., Helps, N. R., Tunggal, B., …Glöckner, G. (2011). Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome research, 21(11), 1882-1891. https://doi.org/10.1101/gr.121137.111

Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas, a clade of altruistic multicellular organisms. To understand genome evolution over long ti... Read More about Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication.

The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (2010)
Journal Article
Vlahou, G., Eliáš, M., von Kleist-Retzow, J., Wiesner, R. J., & Rivero, F. (2011). The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum. European journal of cell biology, 90(4), 342-355. https://doi.org/10.1016/j.ejcb.2010.10.012

Ras-related GTPases of the Miro family have been implicated in mitochondrial homeostasis and microtubule-dependent transport. They consist of two GTP-binding domains separated by calcium-binding motifs and of a C-terminal transmembrane domain that ta... Read More about The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum.

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I (2010)
Journal Article
Mondal, S., Burgute, B., Rieger, D., Müller, R., Rivero, F., Faix, J., …Noegel, A. A. (2010). Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I. PLoS ONE, 5(11), Article e15440. https://doi.org/10.1371/journal.pone.0015440

Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during... Read More about Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I.

Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium (2009)
Journal Article
Grimm-Gunter, E. M. S., Grimm-Guenter, E. S., Ferrary, E., Grimm-Günter, E. S., Hurbain, I., Louvard, D., …Smyth, N. (2009). Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Molecular Biology of the Cell, 20(10), 2549-2562. https://doi.org/10.1091/mbc.e08-10-1030

Plastin 1 (I-plastin, fimbrin) along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli. We demonstrate here that plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly con... Read More about Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism (2008)
Journal Article
Schenková, K., Aspenström, P., Berthold, J., Ramos, S., Miura, Y., Furukawa, M., & Rivero-Crespo, F. (2008). Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism. Experimental Cell Research, 314(19), 3453-3465. https://doi.org/10.1016/j.yexcr.2008.09.005

RhoBTB proteins are atypical members of the Rho family of small GTPases. Two of the three RhoBTB proteins, RhoBTB1 and RhoBTB2, have been proposed as tumor suppressors and might function as adaptors of Cul3-dependent ubiquitin ligase complexes. Using... Read More about Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism.

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions (2008)
Journal Article
Mondal, S., Bakthavatsalam, D., Steimle, P., Gassen, B., Rivero, F., & Noegel, A. A. (2008). Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. Journal of Cell Biology, 181(5), 747-760. https://doi.org/10.1083/jcb.200710111

Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can bind to F-actin, has the potential to form complexes... Read More about Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.

Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability (2008)
Journal Article
Rivero, F., Xiong, H., Rivero-Crespo, F., Euteneuer, U., Mondal, S., Mana-Capelli, S., …Noegel, A. A. (2008). Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic, 9(5), 708-724. https://doi.org/10.1111/j.1600-0854.2008.00721.x

The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in D... Read More about Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.