Skip to main content

Browse


What are the main symptoms and concerns reported by patients with advanced chronic heart failure?—a secondary analysis of the Palliative care Outcome Scale (POS) and Integrated Palliative care Outcome Scale (IPOS) (2019)
Journal Article
Kane, P., Dunleavy, L., Gadoud, A., Guo, P., Oriani, A., & Murtagh, F. E. (2019). What are the main symptoms and concerns reported by patients with advanced chronic heart failure?—a secondary analysis of the Palliative care Outcome Scale (POS) and Integrated Palliative care Outcome Scale (IPOS). Annals of palliative medicine, 8(5), 775-780. https://doi.org/10.21037/apm.2019.08.10

© Annals of Palliative Medicine. All rights reserved. There is a lack of valid disease-specific patient-reported outcome measures (PROMs) for detecting symptoms and concerns in patients with advanced chronic heart failure (CHF). The Palliative care O... Read More about What are the main symptoms and concerns reported by patients with advanced chronic heart failure?—a secondary analysis of the Palliative care Outcome Scale (POS) and Integrated Palliative care Outcome Scale (IPOS).

The effect of radioiodine treatment on the diseased thyroid gland (2019)
Journal Article
Riley, A. S., McKenzie, G. A. G., Green, V., Schettino, G., England, R. J. A., & Greenman, J. (in press). The effect of radioiodine treatment on the diseased thyroid gland. International Journal of Radiation Biology, 1-10. https://doi.org/10.1080/09553002.2019.1665206

Purpose: Radioiodine (I131) therapy is the treatment mainstay for several benign and malignant thyroid disorders, however I131 is known to cause DNA damage and liberation of thyroidal self-antigens inducing secondary immunoreactivity. The exact mecha... Read More about The effect of radioiodine treatment on the diseased thyroid gland.

Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (2019)
Journal Article
Smith, G. E., Palmer, J., Pymer, S., Smith, G. E., Harwood, A. E., Ingle, L., …Chetter, I. C. (2019). Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. The Cochrane database of systematic reviews, 2019(9), https://doi.org/10.1002/14651858.cd013407

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of prehabilitation (preoperative exercise, either alone or in combination with nutritional or psychological interventions or both)... Read More about Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease.

Anti-fibrotic effects of curcumin and some of its analogues in the heart (2019)
Journal Article
Gorabi, A. M., Hajighasemi, S., Kiaie, N., Rosano, G. M. C., Sathyapalan, T., Al-Rasadi, K., & Sahebkar, A. (2019). Anti-fibrotic effects of curcumin and some of its analogues in the heart. Heart Failure Reviews, https://doi.org/10.1007/s10741-019-09854-6

Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, wh... Read More about Anti-fibrotic effects of curcumin and some of its analogues in the heart.

Mental wellbeing in bereaved carers: A Health Survey for England population study (2019)
Journal Article
Hodiamont, F., Allgar, V., Currow, D. C., & Johnson, M. J. (in press). Mental wellbeing in bereaved carers: A Health Survey for England population study. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2019-001957

Objectives The experience of caregiving may affect carers’ well-being into bereavement. We explored associations between mental well-being and previous experience of bereavement of, and caring for, someone close at the end-of-life. Methods An end-... Read More about Mental wellbeing in bereaved carers: A Health Survey for England population study.

Family display, family type, or community? Limitations in the application of a concept (2019)
Journal Article
Walsh, J., McNamee, S., & Seymour, J. (2019). Family display, family type, or community? Limitations in the application of a concept. Families, Relationships and Societies, https://doi.org/10.1332/204674319x15647592551202

In this paper we develop the concept of family display by responding to David Morgan’s suggestion that researchers should consider whether ‘family displays’ are used to convey a ‘type’ of Family. We do so by applying the concept to the accounts of mi... Read More about Family display, family type, or community? Limitations in the application of a concept.

Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome (2019)
Journal Article
Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., …Atkin, S. L. (2019). Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome. Clinical Endocrinology, https://doi.org/10.1111/cen.14087

Long non‐coding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women o... Read More about Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome.

Improving the quality of life of people with advanced respiratory disease and severe breathlessness (2019)
Journal Article
Booth, S., & Johnson, M. J. (2019). Improving the quality of life of people with advanced respiratory disease and severe breathlessness. Breathe, 15(3), 198-215. https://doi.org/10.1183/20734735.0200-2019

Advanced respiratory disease (ARD) imposes a greater symptom burden than many cancers but without comparable recognition of the need for supportive and palliative care or the infrastructure for its systematic delivery. Consequently, many people with... Read More about Improving the quality of life of people with advanced respiratory disease and severe breathlessness.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Vince, R. V., Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., …Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure (2019)
Journal Article
Pellicori, P., Urbinati, A., Kaur, K., Zhang, J., Shah, P., Kazmi, S., …Clark, A. L. (2019). Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure. The American journal of cardiology, https://doi.org/10.1016/j.amjcard.2019.08.018

Heart failure (HF) and atrial fibrillation (AF) commonly co-exist. We aimed to determine the prevalence and incidence of AF in ambulatory patients with HF.

Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study (2019)
Journal Article
Buture, A., Boland, J. W., Ahmed, F., & Dikomitis, L. (2019). Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study. Journal of Multidisciplinary Healthcare, 12, 691-698. https://doi.org/10.2147/jmdh.s207128

Introduction and objective: The diagnosis of primary headaches is based on the International Classification of Headache Disorders (ICHD-3). Cluster headache (CH), a debilitating primary headache, is often misdiagnosed as migraine. In the absence of b... Read More about Images depicting headache pain – a tool to aid the diagnosis of cluster headache: a pilot study.

Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence (2019)
Journal Article
Nickolay, T., Nichols, S., Ingle, L., & Hoye, A. (2019). Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence. Current Cardiology Reviews, 15, https://doi.org/10.2174/1573403x15666190819144336

Coronary collateral vessels supply blood to areas of myocardium at risk after arterial occlusion. Flow through these channels is driven by a pressure gradient between the donor and occluded artery. Concomitant with increased collateral flow is an inc... Read More about Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence.

Therapeutic effects of Crocin in autoimmune diseases: A review (2019)
Journal Article
Korani, S., Korani, M., Sathyapalan, T., & Sahebkar, A. (2019). Therapeutic effects of Crocin in autoimmune diseases: A review. BioFactors, https://doi.org/10.1002/biof.1557

The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple... Read More about Therapeutic effects of Crocin in autoimmune diseases: A review.

Oral modified release morphine for breathlessness in chronic heart failure: a randomised placebo-controlled trial (2019)
Journal Article
Johnson, M., Cockayne, S., Currow, D., Bell, K., Hicks, K., Fairhurst, C., …Clark, A. (in press). Oral modified release morphine for breathlessness in chronic heart failure: a randomised placebo-controlled trial. ESC Heart Failure, https://doi.org/10.1002/ehf2.12498

ABSTRACT Aims: Morphine is shown to relieve chronic breathless in chronic obstructive pulmonary disease. There are no definitive data in people with heart failure. We aimed to determine the effectiveness and cost-effectiveness of 12 weeks’ morphine... Read More about Oral modified release morphine for breathlessness in chronic heart failure: a randomised placebo-controlled trial.

The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study (2019)
Journal Article
Sweeney, E., Yu, Z. M., Dummer, T. J. B., Cui, Y., DeClercq, V., Forbes, C., …Adisesh, A. (in press). The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study. International Archives of Occupational and Environmental Health, https://doi.org/10.1007/s00420-019-01459-8

Purpose To evaluate the relationship between anthropometric measures and cardiometabolic health in shift workers compared to non-shift workers. Methods A population health study was conducted with 4155 shift workers and 8258 non-shift workers fr... Read More about The relationship between anthropometric measures and cardiometabolic health in shift work: findings from the Atlantic PATH Cohort Study.

High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death (2019)
Journal Article
Cleland, J. G. F., Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., …Cleland, J. (2020). High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death. Cardiovascular research, 116(1), 91-100. https://doi.org/10.1093/cvr/cvz198

Aims: Plasma concentrations of high sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP,... Read More about High sensitivity C-Reactive Protein in Chronic heart failure: Patient Characteristics, Phenotypes and mode of death.

Multi-disciplinary palliative care is effective in people with symptomatic heart failure: a systematic review and narrative synthesis (2019)
Journal Article
Datla, S., Verberkt, C. A., Hoye, A., Janssen, D., & Johnson, M. J. (2019). Multi-disciplinary palliative care is effective in people with symptomatic heart failure: a systematic review and narrative synthesis. Palliative medicine, 33(8), 1003-1016. https://doi.org/10.1177/0269216319859148

Background: Despite recommendations, people with heart failure have poor access to palliative care. Aim: To identify the evidence in relation to palliative care for people with symptomatic heart failure. Design: Systematic review and narrative synt... Read More about Multi-disciplinary palliative care is effective in people with symptomatic heart failure: a systematic review and narrative synthesis.

Optimised clinical study recruitment in palliative care: success strategies and lessons learned (2019)
Journal Article
White, C., Noble, S., Watson, M., Swan, F., Nelson, A., & Johnson, M. (2019). Optimised clinical study recruitment in palliative care: success strategies and lessons learned. BMJ supportive & palliative care, . https://doi.org/10.1136/bmjspcare-2019-001820

Recruitment challenges to clinical research studies in palliative care settings, particularly in hospices, are well documented. However, a recent study (Hospice Inpatient Deep vein thrombosis Detection Study (HIDDen)) performed across five hospices... Read More about Optimised clinical study recruitment in palliative care: success strategies and lessons learned.

T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface (2019)
Journal Article
Li, P., Rubaiy, H. N., Chen, G., Hallett, T., Zaibi, N., Zeng, B., …Xu, S. (in press). T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface. British Journal of Pharmacology, https://doi.org/10.1111/bph.14788

Background and purpose Mibefradil (Mib), a T‐type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on ORAI st... Read More about T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface.

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study (2019)
Journal Article
Morice, A. H., Kitt, M. M., Ford, A. P., Tershakovec, A. M., Wu, W., Brindle, K., …Wright, C. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study. The European respiratory journal, 54(1), https://doi.org/10.1183/13993003.00439-2019

We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge. In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant... Read More about The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study.


;