All Outputs (2)

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells (2012)
Journal Article
Claessens, A., Adams, Y., Ghumra, A., Lindergard, G., Buchan, C. C., Andisi, C., …Rowe, J. A. (2012). A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 109(26), E1772-E1781. https://doi.org/10.1073/pnas.1120461109

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite a... Read More about A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.

Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites (2012)
Journal Article
Ghumra, A., Semblat, J. P., Ataide, R., Kifude, C., Adams, Y., Claessens, A., …Rowe, J. A. (2012). Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites. PLoS Pathogens, 8(4), Article e1002665. https://doi.org/10.1371/journal.ppat.1002665

Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion m... Read More about Induction of strain-transcending antibodies against group A PfEMP1 surface antigens from virulent malaria parasites.