All Outputs (2)

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens (2012)
Journal Article
Caserta, S., Borger, J. G., & Zamoyska, R. (2012). Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical reviews in immunology, 32(2), 97-126. https://doi.org/10.1615/critrevimmunol.v32.i2.10

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolyti... Read More about Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells (2012)
Journal Article
Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A. S., …Zamoyska, R. (2012). Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE, 7(4), e35466. https://doi.org/10.1371/journal.pone.0035466

Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibito... Read More about Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.