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Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma (2015)
Journal Article
Wong, B. Y. W., Stafford, N. D., Green, V. L., & Greenman, J. (2016). Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head & neck, 38(S1), E1903-E1908. https://doi.org/10.1002/hed.24346

© 2015 Wiley Periodicals, Inc.. Background The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in pati... Read More about Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.

Rho Signaling in Dictyostelium discoideum (2015)
Journal Article
Rivero Crespo, F., & Xiong, H. (2016). Rho Signaling in Dictyostelium discoideum. International review of cell and molecular biology, 322, 61-181. https://doi.org/10.1016/bs.ircmb.2015.10.004

© 2016 Elsevier Inc. Small GTPases of the Rho family are ubiquitous molecular switches involved in the regulation of most actin cytoskeleton dependent processes and many other processes not directly linked to actin. D. discoideum is a well-establishe... Read More about Rho Signaling in Dictyostelium discoideum.

Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse (2015)
Journal Article
Matsakas, A., Prosdocimo, D. A., Mitchell, R., Collins-Hooper, H., Giallourou, N., Swann, J. R., …Patel, K. (2015). Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse. Skeletal muscle, 5(1), Article 38. https://doi.org/10.1186/s13395-015-0063-5

© 2015 Matsakas et al. Background: Obese adults are prone to develop metabolic and cardiovascular diseases. Furthermore, over-weight expectant mothers give birth to large babies who also have increased likelihood of developing metabolic and cardiovas... Read More about Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse.

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces (2015)
Journal Article
Caley, M. P., King, H., Shah, N., Wang, K., Rodriguez-Teja, M., Gronau, J. H., …Sturge, J. (2016). Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clinical & experimental metastasis, 33(2), 151-165. https://doi.org/10.1007/s10585-015-9765-7

The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells... Read More about Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.

Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin (2015)
Journal Article
Entract, G. M., Bryden, F., Domarkas, J., Savoie, H., Allott, L., Archibald, S. J., …Boyle, R. W. (2015). Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin. Molecular pharmaceutics, 12(12), 4414-4423. https://doi.org/10.1021/acs.molpharmaceut.5b00606

Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging efficacy of positron emission tom... Read More about Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin.

Medical therapy, percutaneous coronary intervention and prognosis in patients with chronic total occlusions (2015)
Journal Article
Ladwiniec, A., Allgar, V., Thackray, S., Alamgir, F., & Hoye, A. (2015). Medical therapy, percutaneous coronary intervention and prognosis in patients with chronic total occlusions. Heart, 101(23), 1907-1914. https://doi.org/10.1136/heartjnl-2015-308181

Objective There is little published data reporting outcomes for those found to have a chronic total coronary occlusion (CTO) that is electively treated medically versus those treated by percutaneous coronary intervention (PCI). We sought to compare l... Read More about Medical therapy, percutaneous coronary intervention and prognosis in patients with chronic total occlusions.

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels (2015)
Journal Article
Beltran-Alvarez, P., & Onwuli, D. O. (2016). An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels. Amino acids, 48(3), 641-651. https://doi.org/10.1007/s00726-015-2122-y

Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of t... Read More about An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis (2015)
Journal Article
Brooks, S. E., Bonney, S. A., Lee, C., Publicover, A., Khan, G., Smits, E. L., …Guinn, B. A. (2015). Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis. PLoS ONE, 10(10), Article e0140483. https://doi.org/10.1371/journal.pone.0140483

Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments... Read More about Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis.

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition (2015)
Journal Article
Middleton, F. K., Patterson, M. J., Elstob, C. J., Fordham, S., Herriott, A., Wade, M. A., …Curtin, N. J. (2015). Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition. Oncotarget, 6(32), 32396-32409. https://doi.org/10.18632/oncotarget.6136

ATR is an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alon... Read More about Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.

Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system (2015)
Journal Article
Keasberry, N. A., Bañobre-López, M., Wood, C., Stasiuk, G. J., Gallo, J., & Long, N. J. (2015). Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system. Nanoscale, 7(38), 16119-16128. https://doi.org/10.1039/c5nr04400f

Magnetic resonance imaging (MRI) is an excellent imaging modality. However the low sensitivity of the technique poses a challenge to achieving an accurate image of function at the molecular level. To overcome this, contrast agents are used; typically... Read More about Tuning the relaxation rates of dual-mode T₁/T₂ nanoparticle contrast agents: a study into the ideal system.

Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging (2015)
Journal Article
Clemente, G. S., Burke, B. P., Nigam, S., Cawthorne, C., & Archibald, S. J. (2015). Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging. European journal of nuclear medicine and molecular imaging, 42(S1), S42. https://doi.org/10.1007/s00259-015-3198-z

Conference abstract

Analogue peptides for the immunotherapy of human acute myeloid leukemia (2015)
Journal Article
Hofmann, S., Mead, A., Malinovskis, A., Hardwick, N. R., & Guinn, B. A. (2015). Analogue peptides for the immunotherapy of human acute myeloid leukemia. Cancer Immunology, Immunotherapy, 64(11), 1357-1367. https://doi.org/10.1007/s00262-015-1762-9

The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the i... Read More about Analogue peptides for the immunotherapy of human acute myeloid leukemia.

Pancreatic β-cell imaging in humans: Fiction or option? (2015)
Journal Article
Laurent, D., Vinet, L., Lamprianou, S., Daval, M., Filhoulaud, G., Ktorza, A., …Hecksher-Sørensen, J. (2016). Pancreatic β-cell imaging in humans: Fiction or option?. Diabetes, Obesity and Metabolism, 18(1), 6-15. https://doi.org/10.1111/dom.12544

Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12 adults. Treatment of disease complications typically consumes ∼10% of healthcare budgets in developed societies. Whilst immune‐mediated destruction of insulin‐secr... Read More about Pancreatic β-cell imaging in humans: Fiction or option?.

Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise (2015)
Journal Article
Peart, D. J., Kirk, R. J., Madden, L. A., & Vince, R. V. (2016). Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise. Amino acids, 48(2), 499-504. https://doi.org/10.1007/s00726-015-2103-1

The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm,... Read More about Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise.

Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue (2015)
Journal Article
Cooper, N. H., Balachandra, J. P., & Hardman, M. J. (2015). Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue. Journal of Investigative Dermatology, 135(12), 3173-3182. https://doi.org/10.1038/jid.2015.338

The skin's mechanical integrity is maintained by an organized and robust dermal extracellular matrix (ECM). Resistance to mechanical disruption hinges primarily on homeostasis of the dermal collagen fibril architecture, which is regulated, at least i... Read More about Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue.

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable' (2015)
Journal Article
Morgan, K., Sadofsky, L. R., & Morice, A. H. (2015). Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Bioscience Reports, 35(5), Article e00255. https://doi.org/10.1042/BSR20150108

© 2015 Authors. Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signallin... Read More about Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate (2015)
Journal Article
Funwie, N. L., Cain, A. N., Fanning, B. Z., Hageman, S. A., Mullens, M., Roberts, T. K., …Prior, T. J. (2015). Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate. Acta Crystallographica Section E: Crystallographic Communications, 71(9), 1073-1076. https://doi.org/10.1107/S2056989015015340

The title compound, [FeCl₂(C₁₄H₃₀N₄)]PF₆, contains Fe³⁺ coordinated by the four nitro­gen atoms of an ethyl­ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa­hedral environment. In contrast to other similar compound... Read More about Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate.

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo (2015)
Journal Article
Jorfi, S., Ansa-Addo, E. A., Kholia, S., Stratton, D., Valley, S., Lange, S., & Inal, J. (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific reports, 5(1), Article 13006. https://doi.org/10.1038/srep13006

Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could be used at lower concentrat... Read More about Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo.

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy (2015)
Journal Article
Pennock, R., Bray, E., Pryor, P., James, S., McKeegan, P., Sturmey, R., & Genever, P. (2015). Human cell dedifferentiation in mesenchymal condensates through controlled autophagy. Scientific reports, 5(1), Article ARTN 13113. https://doi.org/10.1038/srep13113

Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacem... Read More about Human cell dedifferentiation in mesenchymal condensates through controlled autophagy.