All Outputs (2)

α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly (2024)
Journal Article
Sennett, C., Jia, W., Khalil, J. S., Hindle, M. S., Coupland, C., Calaminus, S. D., Langer, J. D., Frost, S., Naseem, K. M., Rivero, F., Ninkina, N., Buchman, V., & Aburima, A. (2024). α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly. Cells, 13(24), Article 2089. https://doi.org/10.3390/cells13242089

Granule secretion is an essential platelet function that contributes not only to haemostasis but also to wound healing, inflammation, and atherosclerosis. Granule secretion from platelets is facilitated, at least in part, by Soluble N-ethylmaleimide-... Read More about α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly.

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner (2024)
Journal Article
Khalil, J. S., Law, R., Raslan, Z., Cheah, L. T., Hindle, M. S., Aburima, A. A., Kearney, M. T., & Naseem, K. M. (2024). Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner. Cells, 13(13), Article 1104. https://doi.org/10.3390/cells13131104

Platelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase... Read More about Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner.