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Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function (2018)
Thesis
Callan, P. (2018). Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221517

Introduction Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic kidney disease. Uraemic cardiomyopathy describes a classical phenotype of left ventricular hypertrophy, diastolic impairment, myocardial... Read More about Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function.

Effects of dietary fats on heart-liver lipid compositions (2018)
Thesis
Alnaam, Y. (2018). Effects of dietary fats on heart-liver lipid compositions. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4193330

Accumulation of lipids in various organs causes many diseases such as obesity, cardiac disorder and dysfunction of the liver. The intake of fats from the diet influences the way that lipids are metabolised in the heart and liver. This provides an ene... Read More about Effects of dietary fats on heart-liver lipid compositions.

Investigating the biological and clinical implications of Endo180 in breast cancer (2017)
Thesis
Wang, K. (2017). Investigating the biological and clinical implications of Endo180 in breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222284

Endo180 is a 180 kDa type-1 transmembrane receptor that belongs to the mannose receptor family and interacts with extracellular / intracellular collagens. Endo180 expression is correlated with tumour grade, disease progression and poor prognosis in s... Read More about Investigating the biological and clinical implications of Endo180 in breast cancer.

Probing cardiac metabolism in uraemic cardiomyopathy (2017)
Thesis
Atkinson, R. (2017). Probing cardiac metabolism in uraemic cardiomyopathy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220698

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). Uraemic cardiomyopathy (UCM) is characterised by structural and cellular remodelling including left ventricular hypertrophy (LVH), metabolic re... Read More about Probing cardiac metabolism in uraemic cardiomyopathy.

Metal oxide nanoparticles as potential MRI contrast agents (2015)
Thesis
Jones, N. E. (2015). Metal oxide nanoparticles as potential MRI contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4218445

Magnetic resonance imaging (MRI) is a common medical imaging modality that does not require the administration of radiopharmaceuticals, as it relies on the inherent nuclear spin of the protons in the tissues and organs. However, it lacks sensitivity... Read More about Metal oxide nanoparticles as potential MRI contrast agents.

Age-associated changes to calcium handling proteins across the whole heart (2012)
Thesis
Hatch, F. S. (2012). Age-associated changes to calcium handling proteins across the whole heart. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215591

Age is a major risk factor for the development of cardiac problems. The ageing process causes significant changes to cardiac structure and function. These are linked with the elderly heart’s diminished ability to respond to cardiac demand and associa... Read More about Age-associated changes to calcium handling proteins across the whole heart.

Development of microfluidic devices for analysis of cardiac tissue ex vivo (2012)
Thesis
Cheah, L. T. (2012). Development of microfluidic devices for analysis of cardiac tissue ex vivo. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4227445

Polydimethylsiloxane (PDMS)–based (Generation 1) and glass–based (Generation 2) microfluidic devices for heart tissue maintenance have been developed. Rat and human heart biopsies were electrically–paced in a 37 oC environment constantly perfused wit... Read More about Development of microfluidic devices for analysis of cardiac tissue ex vivo.

Impact of dietary manipulation on cardiac hypertrophy (2012)
Thesis
Butler, T. J. P. (2012). Impact of dietary manipulation on cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219424

Left ventricular hypertrophy (LVH) is a significant risk factor for the development of heart failure (HF), the incidence of which is increased by obesity. Diets high in fat and sugar have been linked with the development of the metabolic syndrome and... Read More about Impact of dietary manipulation on cardiac hypertrophy.

The impact of erythropoietin on uraemic cardiomyopathy (2009)
Thesis
Smith, K. (2009). The impact of erythropoietin on uraemic cardiomyopathy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4209403

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). The uraemic heart is characterised by cellular and structural remodelling, including left ventricular hypertrophy LVH), which contribute to hea... Read More about The impact of erythropoietin on uraemic cardiomyopathy.

The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents (2008)
Thesis
Sparke, A. E. (2008). The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212783

Multimodality imaging agents have the potential to be detected in both MRI and optical imaging experiments allowing for visualisation of biological systems from the cellular level up to the whole body. Lanthanide complexes have shown great promise as... Read More about The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents.

Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy (2007)
Thesis
Frentzou, G. A. (2007). Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215164

Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Card... Read More about Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy.

Studies of ischaemia and reperfusion in cardiac hypertrophy (2002)
Thesis
Richardson, S. .. (2002). Studies of ischaemia and reperfusion in cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4217972

Cardiac hypertrophy may be associated with an enhanced susceptibility to ischaemic/reperfusion injury but the mechanisms remain unresolved. There is evidence for an increased dependence on glucose metabolism in cardiac hypertrophy, which may be benef... Read More about Studies of ischaemia and reperfusion in cardiac hypertrophy.

Biochemical adaptations in cardiac hypertrophy (2001)
Thesis
Clarke, S. J. (2001). Biochemical adaptations in cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222088

Cardiac hypertrophy is the adaptive response of the heart to chronic overload. The metabolic adaptations that occur during hypertrophy are initially beneficial, but can ultimately deteriorate into heart failure. The mechanisms underlying this are unk... Read More about Biochemical adaptations in cardiac hypertrophy.