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Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. (2023). Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Investigation of the effects of anticoagulants on tissue factor mediated cellular processes (2021)
Thesis
Featherby, S. (2021). Investigation of the effects of anticoagulants on tissue factor mediated cellular processes. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223521

Thrombotic complications are common in cancer patients and are amongst the leading causes of morbidity and mortality. Recently, it was reported that treatment of cancer patients with the low molecular weight heparin (LMWH) family of anticoagulants ca... Read More about Investigation of the effects of anticoagulants on tissue factor mediated cellular processes.

An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor (2020)
Thesis
Mohammad, M. A. (2020). An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222998

The signalling arising from tissue factor (TF) has been associated with cellular homeostasis as well as haemostasis and, is particularly pertinent in carcinogenesis and cancer progression. The formation of the TF-FVIIa complex is known to activate pr... Read More about An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor.

Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells (2019)
Thesis
Adeniran, O. I. (2019). Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222358

Most standard anticancer drugs are non-selective in their cytotoxicity towards cancerous versus normal cells. Therefore, there is a need for the development of selective and targeted anticancer agents. Previous studies have reported upregulation of t... Read More about Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells.

A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE (2019)
Thesis
Benelhaj, N. E. (2019). A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222310

Background: The clinical course of incidental pulmonary embolism in cancer population represents an area of controversy. It presents a growing challenge for clinicians because of a lack of prospective data. Aim: This research aims to investigate t... Read More about A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE.

Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells (2018)
Thesis
Ethaeb, A. M. (2018). Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220989

Tissue factor (TF) is the main initiator of blood coagulation. In addition to its procoagulant property, TF has the ability to regulate various functions within cells including proliferation, angiogenesis and apoptosis. These outcomes appear to depen... Read More about Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells.

Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei (2017)
Thesis
Zheng, F. (2017). Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221817

Trypanosoma brucei is a medically important protozoan parasite causing African sleeping sickness in humans. Treatment of this disease is possible, but is hindered by the limited availability of effective drugs as well as the rapid emergence of drug r... Read More about Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei.

An investigation into the mechanisms of tissue factor-mediated apoptosis in endothelial cells (2014)
Thesis
ElKeeb, A. M. (2014). An investigation into the mechanisms of tissue factor-mediated apoptosis in endothelial cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4217145

Cells are known to express and release tissue factor (TF) following activation. In addition, endothelial cells are capable of acquiring TF carried by circulating microvesicles. Accumulation of TF in the endothelium contributes to chronic pathological... Read More about An investigation into the mechanisms of tissue factor-mediated apoptosis in endothelial cells.

Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles (2013)
Thesis
Mah, P. M. (2013). Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215976

Overexpression of tissue factor and its release as microparticles is a common feature of aggressive cancer. Furthermore, increased levels of tissue factor have been detected in the tumour associated microvascular endothelial cells. The accumulation o... Read More about Examination of the up-regulation and transfer of tissue factor to endothelial cells by tumour-derived microparticles.

Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB (2013)
Thesis
Fountain, D. L. (2013). Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215936

The association between thrombosis and cancer has long been established. Tissue factor (TF), the initiator of the extrinsic pathway in the blood coagulation cascade, has been implicated as one of the most important physiological factors causing such... Read More about Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor κB.

Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants (2011)
Thesis
Ray, B. (2011). Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211926

Introduction: The primary goal in the management of intermittent claudication is to decrease cardiovascular morbidity and mortality by disease modifying therapy. However percutaneous transluminal angioplasty (PTA) is often performed to improve limb r... Read More about Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants.

Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy (2007)
Thesis
Frentzou, G. A. (2007). Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215164

Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Card... Read More about Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy.